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pro vyhledávání: '"Jacob S. Kim"'
Autor:
Sandra Morandell, H. Christian Reinhardt, Ian G. Cannell, Jacob S. Kim, Daniela M. Ruf, Tanya Mitra, Anthony D. Couvillon, Tyler Jacks, Michael B. Yaffe
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 868-877 (2013)
A fundamental limitation in devising new therapeutic strategies for killing cancer cells with DNA damaging agents is the need to identify synthetic lethal interactions between tumor-specific mutations and components of the DNA damage response (DDR) i
Externí odkaz:
https://doaj.org/article/7c095d9df4e04a3398bb31e03f633601
Autor:
Christian D. Ellson, Ingred Goretti Riça, Jacob S. Kim, Yu-ming M Huang, Daniel Lim, Tanya Mitra, Albert Hsu, Erin X. Wei, Christopher D. Barrett, Leo E. Otterbein, Carl J. Hauser, Martin Wahl, Heinrich Delbrück, Udo Heinemann, Hartmut Oschkinat, Chia-en A. Chang, Michael B. Yaffe
Publikováno v:
Journal of molecular biology. 434(9)
The neutrophil NADPH oxidase produces both intracellular and extracellular reactive oxygen species (ROS). Although oxidase activity is essential for microbial killing, and ROS can act as signaling molecules in the inflammatory process, excessive extr
Autor:
Matthias Stephan, Monique J. Kauke, Eric F. Zhu, Alessandro Angelini, Louis M. Weiner, Robert T. Williams, Kelly D. Moynihan, Jacob S. Kim, Byron Hua Kwan, Darrell J. Irvine, Michael B. Yaffe, K. Dane Wittrup, Glenn Dranoff, Rishi Surana, Martin C. Mihm, Cary F. Opel, Shuning A. Gai
Publikováno v:
PMC
Cancer immunotherapies under development have generally focused on either stimulating T cell immunity or driving antibody-directed effector functions of the innate immune system such as antibody-dependent cell-mediated cytotoxicity (ADCC). We find th