Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jacob Richards"'
Autor:
Lauren M. Lepone, Renee N. Donahue, Italia Grenga, Simon Metenou, Jacob Richards, Christopher R. Heery, Ravi A. Madan, James L. Gulley, Jeffrey Schlom
Publikováno v:
Journal of Circulating Biomarkers, Vol 5 (2016)
Recent advances in human immunology have led to the identification of novel immune cell subsets and the biological function of many of these subsets has now been identified. The recent US Food and Drug Administration approval of several immunotherape
Externí odkaz:
https://doaj.org/article/23c30e00abff4bf7bf35e3c9d7b91d1e
Autor:
Jennifer B. Weggen, Ashley M. Darling, Aaron S. Autler, Austin C. Hogwood, Kevin P. Decker, Jacob Richardson, Gina Tuzzolo, Ryan S. Garten
Publikováno v:
Experimental Physiology, Vol 109, Iss 6, Pp 992-1003 (2024)
Abstract Young individuals with post‐traumatic stress disorder (PTSD) display peripheral vascular and autonomic nervous system dysfunction, two factors potentially stemming from a redox imbalance. It is currently unclear if these aforementioned fac
Externí odkaz:
https://doaj.org/article/d6d6f28737df470d8f7725375443fdd8
Autor:
Charles S. Wingo, Ling Yu, Meaghan Holzworth, Jacob Richards, I. Jeanette Lynch, Kit-Yan Cheng, Michelle L. Gumz, Abdel A. Alli
Publikováno v:
Am J Physiol Renal Physiol
Circadian rhythms govern physiological functions and are important for overall health. The molecular circadian clock comprises several transcription factors that mediate circadian control of physiological function, in part, by regulating gene express
Autor:
Xueliang Pan, Gregory B. Lesinski, Jeffrey Schlom, Renee N. Donahue, Thomas Olencki, Jacob Richards, Taylor R. Brooks, Volodymyr Karpa, Bonnie Paul, William E. Carson, Caroline Jochems, Megan C. Duggan, Elizabeth Foust, Susheela Tridandapani
Publikováno v:
Cancer Immunology, Immunotherapy. 65:1353-1364
Prime-boost vaccination with recombinant (r) vaccinia(V)-CEA(6D)-TRICOM (triad of co-stimulatory molecules B7.1, ICAM-1 and LFA-3) and rFowlpox(F)-CEA(6D)-TRICOM infect antigen-presenting cells and direct expression of co-stimulatory molecules. We hy
Autor:
James W. Hodge, Rika Fujii, Eitan Friedman, Jacob Richards, Jeffrey Schlom, Kwong Y. Tsang, Christopher R. Heery
Publikováno v:
Oncotarget
Chordoma, a rare bone tumor derived from the notochord, has been shown to be resistant to conventional therapies. Checkpoint inhibition has shown great promise in immune-mediated therapy of diverse cancers. The anti-PD-L1 mAb avelumab is unique among
Autor:
Anna R. Kwilas, James W. Hodge, Sofia R. Gameiro, Ashley B. Hall, Andressa Ardiani, Jacob Richards
Publikováno v:
Oncotarget
Among breast cancer types, triple-negative breast cancer (TNBC) has the fewest treatment options and the lowest 5-year survival rate. Androgen receptor (AR) inhibition has displayed efficacy against breast cancer preclinically and is currently being
Publikováno v:
Blood Pressure Monitoring. 19:249-254
The circadian clock plays an integral role in the regulation of physiological processes, including the regulation of blood pressure. However, deregulation of the clock can lead to pathophysiological states including hypertension. Recent work has impl
Publikováno v:
Journal of Biological Chemistry. 289:11791-11806
It has been well established that blood pressure and renal function undergo circadian fluctuations. We have demonstrated that the circadian protein Per1 regulates multiple genes involved in sodium transport in the collecting duct of the kidney. Howev
Autor:
Brian D. Cain, Michelle L. Gumz, Jacob Richards, Sean All, Charles S. Wingo, Amanda K. Welch, Kit-Yan Cheng, Sarah J. Barilovits
Publikováno v:
Life sciences
AimsThe present study is designed to consider a role for the circadian clock protein Per1 in the regulation of the endothelin axis in mouse kidney, lung, liver and heart. Renal endothelin-1 (ET-1) is a regulator of the epithelial sodium channel (ENaC
Autor:
Lauren A. Jeffers, Charles S. Wingo, Brian D. Cain, Michelle L. Gumz, Jacob Richards, Kit-Yan Cheng, Lisa R. Stow, I. Jeanette Lynch, Megan M. Greenlee
Publikováno v:
Hypertension. 59:1151-1156
The circadian clock protein period 1 (Per1) contributes to the regulation of expression of the α subunit of the renal epithelial sodium channel at the basal level and in response to the mineralocorticoid hormone aldosterone. The goals of the present