Výsledky vyhledávání - "Jacob R. Shaw"

Akademický článek

Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

Autor: Nhu Truong, Andrea L. Cottingham, Shruti Dharmaraj, Jacob R. Shaw, Jackline Joy Martin Lasola, Christopher C. Goodis, Steven Fletcher, Ryan M. Pearson

Publikováno v: Bioengineering & Translational Medicine, Vol 9, Iss 1, Pp n/a-n/a (2024)

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor

Externí odkaz: https://doaj.org/article/74f4dfb8d1824006bfb7e0c6cbb7175e

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Modified Suberoylanilide Hydroxamic Acid Reduced Drug-Associated Immune Cell Death and Organ Damage under Lipopolysaccharide Inflammatory Challenge

Autor: Nhu Truong, Christopher C. Goodis, Andrea L. Cottingham, Jacob R. Shaw, Steven Fletcher, Ryan M. Pearson

Publikováno v: ACS pharmacologytranslational science. 5(11)

Histone deacetylase inhibitors (HDACi) induce potent anti-inflammatory responses when used to treat inflammatory diseases. Suberoylanilide hydroxamic acid (SAHA), a pan-HDACi, decreases pro-inflammatory cytokine levels and attenuates cytokine storm i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e7ca86d250bb77203bde0b639e2572
https://pubmed.ncbi.nlm.nih.gov/36407956

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