Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jacob Pourat"'
Autor:
Patrícia M. R. Pereira, Sai Kiran Sharma, Lukas M. Carter, Kimberly J. Edwards, Jacob Pourat, Ashwin Ragupathi, Yelena Y. Janjigian, Jeremy C. Durack, Jason S. Lewis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Trastuzumab binding to tumor cells depends on the availability of HER2 at the cell membrane. Here the authors show that caveolin-1 (CAV1) regulates HER2 density at the cell membranes and that CAV1 gene knockdown or protein depletion via the cholester
Externí odkaz:
https://doaj.org/article/655bc247cda34be5801b730bd0910363
Autor:
Outi Keinänen, Kimberly Fung, Jacob Pourat, Vilma Jallinoja, Delphine Vivier, NagaVara Kishore Pillarsetty, Anu J. Airaksinen, Jason S. Lewis, Brian M. Zeglis, Mirkka Sarparanta
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived radioisotopes for pret
Externí odkaz:
https://doaj.org/article/0fcf170bc14143cab53aa92849dad3cf
Autor:
Jason S. Lewis, John T. Poirier, Scott J. Dylla, Charles M. Rudin, Brian M. Zeglis, David Liu, Vikram Sisodiya, Viola Allaj, Eric B. Johansen, Kristen M. Cunanan, Joseph Sandoval, Sheila Bheddah, Kumiko Isse, Omar Hamdy, Eric E. Gardner, Alexander J. Bankovich, Alessandra Piersigilli, Sean D. Carlin, Dalya Abdel-Atti, Jacob Pourat, Sai Kiran Sharma
Supplemental data detailing the methods and results for the synthesis and in vitro characterization of the radioimmunoconjugates, longitudinal PET imaging and ex vivo analyses in various models described within the main text.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f94bdb09e5ffcd3243607bd018f429
https://doi.org/10.1158/0008-5472.22414472.v1
https://doi.org/10.1158/0008-5472.22414472.v1
Autor:
Jason S. Lewis, John T. Poirier, Scott J. Dylla, Charles M. Rudin, Brian M. Zeglis, David Liu, Vikram Sisodiya, Viola Allaj, Eric B. Johansen, Kristen M. Cunanan, Joseph Sandoval, Sheila Bheddah, Kumiko Isse, Omar Hamdy, Eric E. Gardner, Alexander J. Bankovich, Alessandra Piersigilli, Sean D. Carlin, Dalya Abdel-Atti, Jacob Pourat, Sai Kiran Sharma
The Notch ligand DLL3 has emerged as a novel therapeutic target expressed in small cell lung cancer (SCLC) and high-grade neuroendocrine carcinomas. Rovalpituzumab teserine (Rova-T; SC16LD6.5) is a first-in-class DLL3-targeted antibody–drug conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e248ab8a2a739fa603425a017db548
https://doi.org/10.1158/0008-5472.c.6508991.v1
https://doi.org/10.1158/0008-5472.c.6508991.v1
Autor:
Brian M. Zeglis, Jason S. Lewis, Prakash Radhakrishnan, Michael A. Hollingsworth, Madi R. Madiyalakan, Elisa de Stanchina, Cory L. Brooks, Brandy White, Huiyong Zhao, Maria S. Jiao, Outi Keinänen, Kimberly J. Edwards, Jacob Pourat, Alessandra Piersigilli, Kyeara N. Mack, Sai Kiran Sharma
Supplementary Figure from ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e9857cedc774d1cc1d3409ad0bd306
https://doi.org/10.1158/1078-0432.22484397
https://doi.org/10.1158/1078-0432.22484397
Autor:
Brian M. Zeglis, Jason S. Lewis, Prakash Radhakrishnan, Michael A. Hollingsworth, Madi R. Madiyalakan, Elisa de Stanchina, Cory L. Brooks, Brandy White, Huiyong Zhao, Maria S. Jiao, Outi Keinänen, Kimberly J. Edwards, Jacob Pourat, Alessandra Piersigilli, Kyeara N. Mack, Sai Kiran Sharma
Supplementary Date from ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770ff576373df973b27a901613efff34
https://doi.org/10.1158/1078-0432.22484403
https://doi.org/10.1158/1078-0432.22484403
Autor:
Brian M. Zeglis, Jason S. Lewis, Prakash Radhakrishnan, Michael A. Hollingsworth, Madi R. Madiyalakan, Elisa de Stanchina, Cory L. Brooks, Brandy White, Huiyong Zhao, Maria S. Jiao, Outi Keinänen, Kimberly J. Edwards, Jacob Pourat, Alessandra Piersigilli, Kyeara N. Mack, Sai Kiran Sharma
Supplementary Table from ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10facca11033330a132967425bda2b31
https://doi.org/10.1158/1078-0432.22484394
https://doi.org/10.1158/1078-0432.22484394
Autor:
Brian M. Zeglis, Jason S. Lewis, Prakash Radhakrishnan, Michael A. Hollingsworth, Madi R. Madiyalakan, Elisa de Stanchina, Cory L. Brooks, Brandy White, Huiyong Zhao, Maria S. Jiao, Outi Keinänen, Kimberly J. Edwards, Jacob Pourat, Alessandra Piersigilli, Kyeara N. Mack, Sai Kiran Sharma
Purpose:Advances in our understanding of the contribution of aberrant glycosylation to the pro-oncogenic signaling and metastasis of tumor cells have reinvigorated the development of mucin-targeted therapies. Here, we validate the tumor-targeting abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1256e83af968e6a13f839c0bd43d019d
https://doi.org/10.1158/1078-0432.c.6531396.v1
https://doi.org/10.1158/1078-0432.c.6531396.v1
Autor:
Jason S. Lewis, John T. Poirier, Brian M. Zeglis, Dalya Abdel-Atti, Thomas R. Dilling, Kimberly J. Edwards, Jacob Pourat, Delphine Vivier, Sebastien Monette, Andrew Chow, Sai Kiran Sharma
A critical benchmark in the development of antibody-based therapeutics is demonstration of efficacy in preclinical mouse models of human disease, many of which rely on immunodeficient mice. However, relatively little is known about how the biology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108ba06cf20a747a823f9c2f265a424e
https://doi.org/10.1158/0008-5472.c.6509973
https://doi.org/10.1158/0008-5472.c.6509973
Autor:
Laura E. Benjamin, George C. Prendergast, Alex Toker, Lawrence F. Brown, Olivier N. Kocher, James B. DuHadaway, Stephanie McNamara, Sharon Shechter, Arturo Bravo-Nuevo, Thuy L. Phung, Jacob Pourat, Lee Mangiante, Carole Perruzzi, Rebekah K. O'Donnell, Ningning Zheng, Durga Udayakumar, Y. Rebecca Chin, Minzhou Huang, Damien Gerald, Shiva Kazerounian
PDF file - 219K, Effects of RhoB deletion on MT-myc induced mammary tumorigenesis in virgin female mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2d16dd392ad017b045b102eb34ff9e
https://doi.org/10.1158/0008-5472.22395177.v1
https://doi.org/10.1158/0008-5472.22395177.v1