Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jacob Paiano"'
Autor:
Faith C Fowler, Bo-Ruei Chen, Nicholas Zolnerowich, Wei Wu, Raphael Pavani, Jacob Paiano, Chelsea Peart, Zulong Chen, André Nussenzweig, Barry P Sleckman, Jessica K Tyler
Publikováno v:
eLife, Vol 11 (2022)
DNA double-strand break (DSB) repair by homologous recombination is confined to the S and G2 phases of the cell cycle partly due to 53BP1 antagonizing DNA end resection in G1 phase and non-cycling quiescent (G0) cells where DSBs are predominately rep
Externí odkaz:
https://doaj.org/article/20fdda038d0c46f1ba37279b0a8d1e09
Autor:
Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia, Elsa Callen, Ana Paola Cotrim, Rajashree A. Deshpande, Yaakov Maman, Amanda Day, Tanya T. Paull, André Nussenzweig
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that th
Externí odkaz:
https://doaj.org/article/fe2f3dab8f70455daf145802e93451d5
Autor:
Mohamed Mahgoub, Jacob Paiano, Melania Bruno, Wei Wu, Sarath Pathuri, Xing Zhang, Sherry Ralls, Xiaodong Cheng, André Nussenzweig, Todd S Macfarlan
Publikováno v:
eLife, Vol 9 (2020)
Meiotic crossovers result from homology-directed repair of DNA double-strand breaks (DSBs). Unlike yeast and plants, where DSBs are generated near gene promoters, in many vertebrates DSBs are enriched at hotspots determined by the DNA binding activit
Externí odkaz:
https://doaj.org/article/1cd9ae76ec8f4b498b795ac0bd86cca7
Autor:
Hongzhi Li, Chen Wang, André Nussenzweig, Raphael Souza Pavani, Nicholas Zolnerowich, Jacob Paiano, Li Zheng, Wei Wu, Barry P. Sleckman, Binghui Shen, Bo-Ruei Chen
Publikováno v:
Genes & Development. 35:1356-1367
Double-strand break (DSB) repair choice is greatly influenced by the initial processing of DNA ends. 53BP1 limits the formation of recombinogenic single-strand DNA (ssDNA) in BRCA1-deficient cells, leading to defects in homologous recombination (HR).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6813987cbee383022ac615a0ce2cc09d
https://doi.org/10.1101/gad.348667.121
https://doi.org/10.1101/gad.348667.121
Autor:
William J. Nathan, Jennifer M. Colón-Mercado, Dali Zong, Kenta Shinoda, Michael E. Ward, Dongpeng Wang, Wei Wu, Maia Parsadanian, Raphael Souza Pavani, Peter J. McHugh, Seol Kyoung Jung, Steve Coon, Raffaella De Pace, Han-Yu Shih, Jacob Paiano, André Nussenzweig, Sarah E. Hill, Chongyi Chen, Solji Park, Rafael Casellas, Niek van Wietmarschen, Elsa Callen, Andres Canela, Keith W. Caldecott, Hana Hanzlikova
Publikováno v:
Nature
Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic neurons(1,2). The cellular genome is subjected to a constant barrage of endoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa542e6d7406cb597c12b65a7f00f105
https://doi.org/10.1038/s41586-021-03468-5
https://doi.org/10.1038/s41586-021-03468-5
Autor:
Faith C Fowler, Bo-Ruei Chen, Nicholas Zolnerowich, Wei Wu, Raphael Pavani, Jacob Paiano, Chelsea Peart, Zulong Chen, André Nussenzweig, Barry P Sleckman, Jessica K Tyler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c51d3e0624e3b90e2a78f18ec983e48f
https://doi.org/10.7554/elife.74700.sa2
https://doi.org/10.7554/elife.74700.sa2
Autor:
Nicholas Zolnerowich, Raphael Souza Pavani, Faith C Fowler, Jacob Paiano, Jessica K. Tyler, Chelsea Peart, Barry P. Sleckman, André Nussenzweig, Bo-Ruei Chen, Wei Wu
DNA double-strand break (DSB) repair by homologous recombination is confined to the S and G2 phases of the cell cycle partly due to 53BP1 antagonizing DNA end resection in G1 phase and non-cycling quiescent (G0) cells where DSBs are predominately rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a04a4e4d10dd5b83637d10f9dbbc7c3
https://doi.org/10.1101/2021.10.21.465258
https://doi.org/10.1101/2021.10.21.465258
Autor:
Faith C, Fowler, Bo-Ruei, Chen, Nicholas, Zolnerowich, Wei, Wu, Raphael, Pavani, Jacob, Paiano, Chelsea, Peart, Zulong, Chen, André, Nussenzweig, Barry P, Sleckman, Jessica K, Tyler
Publikováno v:
eLife. 11
DNA double-strand break (DSB) repair by homologous recombination is confined to the S and G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8933520475c876c6d7c4857b440d294
https://pubmed.ncbi.nlm.nih.gov/35575473
https://pubmed.ncbi.nlm.nih.gov/35575473
Autor:
Heyuan Li, Yin Zhai, Susan M. Rosenberg, John P. Pribis, Jacob Paiano, P. J. Hastings, Jingjing Liu, Devon M. Fitzgerald, Ralf B. Nehring, Jun Xia, Qian Mei, André Nussenzweig
Publikováno v:
Science Advances
Caught in the act, DNA reaction intermediates in bacterial genomes may illuminate disease-driving regions in human chromosomes.
Chromosomal fragile sites are implicated in promoting genome instability, which drives cancers and neurological disea
Chromosomal fragile sites are implicated in promoting genome instability, which drives cancers and neurological disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccfc9f9246a9b0bf295a379d2a31c2f
http://europepmc.org/articles/PMC8213236
http://europepmc.org/articles/PMC8213236