Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jacob P. Debelak"'
Autor:
John A. Watts, John G. Younger, Jacob P. Debelak, Lisa R. Thornton, Alan E. Jones, Jeffrey A. Kline
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 284:L1072-L1081
Our objective was to test the effect of inhibition of thromboxane synthase versus inhibition of cyclooxygenase (COX)-1/2 on pulmonary gas exchange and heart function during simulated pulmonary embolism (PE) in the rat. PE was induced in rats via intr
Autor:
Fiona E. Yull, John W. Christman, William C. Chapman, Jacob P. Debelak, L. James Wudel, Ruxanna T. Sadikot, Timothy S. Blackwell, Duco E. Jansen
Publikováno v:
Journal of Gastrointestinal Surgery. 6:264-270
Hepatic injury from cryoablation has been associated with multisystem injury, including adult respiratory distress syndrome, renal insufficiency, and coagulopathy; but the responsible mechanisms have not been well defined. In the present study we inv
Autor:
William C. Chapman, Jacob P. Debelak, Yu Shyr, J. Kelly Wright, Tara M. Allos, L. James Wudel
Publikováno v:
Journal of Surgical Research. 102:50-56
Introduction. An increased risk of gallstone (GS) formation has been linked to obesity and to episodes of rapid and significant weight loss. Previous reports have suggested that bile salt therapy (ursodeoxycholic acid) or prostaglandin inhibition (ib
Autor:
Kay Washington, Caroline Gobbell, Dora R. Sztipanovits, Yu Shyr, William C. Chapman, Jacob P. Debelak, Sandy Olson
Publikováno v:
Journal of Surgical Research. 95:1-7
We have previously shown that hepatic cryoablation (cryo), but not partial hepatectomy, induces a systemic inflammatory response, with distant organ injury and overproduction of NF-kappaB-dependent cytokines. Serum tumor necrosis factor-alpha (TNF-al
Autor:
C. Wright Pinson, Phillip E. Williams, Donna J. Schot, David H. Harley, William C. Chapman, Jacob P. Debelak, Kay Washington, John W. Christman, Annapurna Venkatakrishnan, Timothy S. Blackwell
Publikováno v:
Surgery. 126:518-526
Background: Previous clinical reports have documented multisystem organ injury after hepatic cryoablation. We hypothesized that hepatic cryosurgery, but not partial hepatectomy, induces a systemic inflammatory response characterized by distant organ
Publikováno v:
The American Surgeon. 65:581-585
Bilioenteric reconstruction using a Roux limb of jejunum is a well-established surgical option for the reconstruction of the proximal bile duct. Previous studies discussing short- and long-term complications of biliary-enteric anastomosis have focuse
Autor:
Kim A. Gainer, Kenneth L. Brigham, R. E. Parker, Timothy S. Blackwell, John W. Christman, C. Wright Pinson, Jacob P. Debelak, William C. Chapman
Publikováno v:
Archives of surgery (Chicago, Ill. : 1960). 135(6)
Hypothesis Hepatic cryoablation of 30% to 35% or more of liver parenchyma in a sheep model results in eicosanoid and nuclear factor–κB (NF-κB)–mediated changes in pulmonary hemodynamics and lung permeability. Setting Laboratory. Interventions A
Autor:
C. Wright Pinson, James B. Atkinson, William C. Chapman, M. Kay Washington, Timothy S. Blackwell, John W. Christman, Annapurna Venkatakrishnan, Jacob P. Debelak
Publikováno v:
Annals of surgery. 231(5)
Hepatic resection remains the standard treatment method for primary and metastatic liver tumors in properly selected patients. 1 However, newer surgical modalities, including cryoablation 2–6 and radiofrequency ablation (RFA), 7–9 have been intro
Autor:
Jacob P. Debelak, C. Wright Pinson, James D. Stefansic, Alan J. Herline, William C. Chapman, Steven L. Hartmann, Robert L. Galloway
Publikováno v:
Archives of surgery (Chicago, Ill. : 1960). 134(6)
Background Liver surgery can be difficult because there are few external landmarks defining hepatic anatomy and because the liver has significant vascularity. Although preoperative tomographic imaging (computed tomography or magnetic resonance imagin
Autor:
J. Kelly Wright, Steven G. Meranze, D. Michael Rose, Murray J. Mazer, C. Wright Pinson, Jacob P. Debelak, C.D Blanke, Amy T Rose, Andrew T Brockenbrough, Taylor K. Blair, William C. Chapman
Publikováno v:
American journal of surgery. 177(5)
BACKGROUND: Hepatocellular carcinoma (HCC) in Western populations has historically been associated with poor survival. METHODS: In this study, we conducted a 7-year retrospective analysis of patients with HCC undergoing transcatheter arterial chemoem