Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jacob P. Brady"'
Autor:
Ulrich Hommel, Konstanze Hurth, Jean-Michel Rondeau, Anna Vulpetti, Daniela Ostermeier, Andreas Boettcher, Jacob Peter Brady, Michael Hediger, Sylvie Lehmann, Elke Koch, Anke Blechschmidt, Rina Yamamoto, Valentina Tundo Dottorello, Sandra Haenni-Holzinger, Christian Kaiser, Philipp Lehr, Andreas Lingel, Luca Mureddu, Christian Schleberger, Jutta Blank, Paul Ramage, Felix Freuler, Joerg Eder, Frédéric Bornancin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Human interleukin-1β (hIL-1β) is a pro-inflammatory cytokine involved in many diseases. While hIL-1β directed antibodies have shown clinical benefit, an orally available low-molecular weight antagonist is still elusive, limiting the appli
Externí odkaz:
https://doaj.org/article/045a20bdd9464a2d8a11a51d75b0961e
Autor:
Huaying Zhao, Yuki Toyama, Zev A Ripstein, Jacob P. Brady, Peter Schuck, Patricia L. Clark, Lewis E. Kay, Robert W. Harkness, Alexander I M Sever, Qing Luan
Publikováno v:
Proc Natl Acad Sci U S A
DegP is an oligomeric protein with dual protease and chaperone activity that regulates protein homeostasis and virulence factor trafficking in the periplasm of gram-negative bacteria. A number of oligomeric architectures adopted by DegP are thought t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773669c114bba7fc5295cdfde7633f57
https://doi.org/10.1073/pnas.2109732118
https://doi.org/10.1073/pnas.2109732118
Publikováno v:
New Journal of Physics, Vol 19, Iss 11, p 115003 (2017)
Biologically functional liquid–liquid phase separation of intrinsically disordered proteins (IDPs) is driven by interactions encoded by their amino acid sequences. Little is currently known about the molecular recognition mechanisms for distributin
Externí odkaz:
https://doaj.org/article/caf7ef3e99d645a08b96a0f096d6ea88
Publikováno v:
Journal of Biomolecular NMR. 68:249-255
We present a pulse scheme that exploits methyl 1H triple-quantum (TQ) coherences for the measurement of diffusion rates of slowly diffusing molecules in solution. It is based on the well-known stimulated echo experiment, with encoding and decoding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc7d205d81067e5069559dec6c309752
https://doi.org/10.1007/s10858-017-0122-9
https://doi.org/10.1007/s10858-017-0122-9
Publikováno v:
J Chem Phys
The physical chemistry of liquid-liquid phase separation (LLPS) of polymer solutions bears directly on the assembly of biologically functional droplet-like bodies from proteins and nucleic acids. These biomolecular condensates include certain extrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfd0b3a16a08ef5aad44570cb537b63
https://doi.org/10.1063/1.5139661
https://doi.org/10.1063/1.5139661
Publikováno v:
Journal of Physical Chemistry B
Journal of Physical Chemistry B, American Chemical Society, 2018, ⟨10.1021/acs.jpcb.8b06820⟩
Journal of Physical Chemistry B, American Chemical Society, 2018, ⟨10.1021/acs.jpcb.8b06820⟩
Solvent exchange rates provide important information about the structural and dynamical properties of biomolecules. A large number of NMR experiments have been developed to measure such rates in proteins, the great majority of which quantify the buil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb4f7d087405c5f67bffe952b039743
https://hal.archives-ouvertes.fr/hal-01916707
https://hal.archives-ouvertes.fr/hal-01916707
Publikováno v:
Journal of the American Chemical Society. 140(6)
R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c61df343d42bb4f0e9b8dfa73b68a526
https://pubmed.ncbi.nlm.nih.gov/29303268
https://pubmed.ncbi.nlm.nih.gov/29303268
Autor:
Yi-Hsuan Lin, Julie D. Forman-Kay, Rui Huang, Timothy J. Nott, Lewis E. Kay, Hue Sun Chan, Alaji Bah, Andrew Baldwin, Patrick Farber, Jacob P. Brady, Ashok Sekhar
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Membrane encapsulation is frequently used by the cell to sequester biomolecules and compartmentalize their function. Cells also concentrate molecules into phase-separated protein or protein/nucleic acid "membraneless organelles" that regulate a host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0f3f861a5945f98a95831e733638f1
https://doi.org/10.1073/pnas.1706197114
https://doi.org/10.1073/pnas.1706197114
Publikováno v:
Journal of biomolecular NMR. 68(4)
We present a pulse scheme that exploits methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::198f3c6a46a253915f443cbd1dec792c
https://pubmed.ncbi.nlm.nih.gov/28717997
https://pubmed.ncbi.nlm.nih.gov/28717997
Biologically functional liquid-liquid phase separation of intrinsically disordered proteins (IDPs) is driven by interactions encoded by their amino acid sequences. Little is currently known about the molecular recognition mechanisms for distributing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0431aedc8aac10e90a9686dc408ff2