Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jacob P van Vloten"'
Autor:
Jacob P van Vloten, Kathy Matuszewska, Mark A A Minow, Jessica A Minott, Lisa A Santry, Madison Pereira, Ashley A Stegelmeier, Thomas M McAusland, Elaine M Klafuric, Khalil Karimi, Joseph Colasanti, D Grant McFadden, James J Petrik, Byram W Bridle, Sarah K Wootton
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Novel therapies are needed to improve outcomes for women diagnosed with ovarian cancer. Oncolytic viruses are multifunctional immunotherapeutic biologics that preferentially infect cancer cells and stimulate inflammation with the potential
Externí odkaz:
https://doaj.org/article/042f07917dda4af9ab08f790da95d074
Autor:
Lisa A. Santry, Jacob P. van Vloten, Amanda W. K. AuYeung, Robert C. Mould, Jacob G. E. Yates, Thomas M. McAusland, James J. Petrik, Pierre P. Major, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionTumor microenvironments are immunosuppressive due to progressive accumulation of mutations in cancer cells that can drive expression of a range of inhibitory ligands and cytokines, and recruitment of immunomodulatory cells, including myel
Externí odkaz:
https://doaj.org/article/0dc2b238fb124dce87ad725117251258
Autor:
Jessica A. Minott, Jacob P. van Vloten, Jake G.E. Yates, Lisa A. Santry, Kathy Matuszewska, Madison Pereira, Melanie M. Goens, Alicia M. Viloria-Petit, Geoffrey A. Wood, Khalil Karimi, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100748- (2023)
Immunotherapies revive host immune responses against tumors by stimulating innate and adaptive immune effector cells with antitumor functions. Thus, detailed studies of immunological cell phenotypes and functions within the tumor microenvironment (TM
Externí odkaz:
https://doaj.org/article/741bb4cb64894b1a844ac39272790cc9
Autor:
Jessica A. Minott, Jacob P. van Vloten, Jacob G. E. Yates, Lily Chan, Geoffrey A. Wood, Alicia M. Viloria-Petit, Khalil Karimi, James J. Petrik, Sarah K. Wootton, Byram W. Bridle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Novel immunotherapies continue to be developed and tested for application against a plethora of diseases. The clinical translation of immunotherapies requires an understanding of their mechanisms. The contributions of antibodies in driving long-term
Externí odkaz:
https://doaj.org/article/290daf6e1e214d409b2203e5bfe374a6
Autor:
Thomas M. McAusland, Jacob P. van Vloten, Lisa A. Santry, Matthew M. Guilleman, Amira D. Rghei, Edgar M. Ferreira, Joelle C. Ingrao, Rozanne Arulanandam, Pierre P. Major, Leonardo Susta, Khalil Karimi, Jean-Simon Diallo, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 306-324 (2021)
The avian paramyxovirus, Newcastle disease virus (NDV), is a promising oncolytic agent that has been shown to be safe and effective in a variety of pre-clinical cancer models and human clinical trials. NDV preferentially replicates in tumor cells due
Externí odkaz:
https://doaj.org/article/e362ae43ee6b4c3790f29c8383e6c1e4
Autor:
Jessica A. Minott, Jacob P. van Vloten, Lily Chan, Yeganeh Mehrani, Byram W. Bridle, Khalil Karimi
Publikováno v:
Cells, Vol 11, Iss 18, p 2858 (2022)
Neutrophils are innate leukocytes with diverse effector functions that allow them to respond to pathogens rapidly. Accumulating evidence has highlighted these cells’ complex roles in the host’s response to viral infections and tumor progression.
Externí odkaz:
https://doaj.org/article/aea8592d85bb4d67a26675be0e23e2a9
Autor:
Jim Petrik, Byram W. Bridle, Sarah K. Wootton, Jack Lawler, Pierre P. Major, Amanda W.K. AuYeung, Jacob P. van Vloten, Lisa A. Santry, Kathy Matuszewska
Supplementary Data Figure 2 Supplementary Data, Figure 2. ID8, CAOV-3 and NOSE cells were infected or mock infected (1x PBS) at an MOI of 0.1. Infected and uninfected cells were collected 24 hours later and stained for Annexin V a marker for early ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0342e15dc576617cc2d651ebb17dd1bd
https://doi.org/10.1158/1078-0432.22476029.v1
https://doi.org/10.1158/1078-0432.22476029.v1
Autor:
Jim Petrik, Byram W. Bridle, Sarah K. Wootton, Jack Lawler, Pierre P. Major, Amanda W.K. AuYeung, Jacob P. van Vloten, Lisa A. Santry, Kathy Matuszewska
Supplementary Figure 1 Supplementary Data, Figure 1. Combination therapy results in decreased ascites fluid volume. At euthanasia, ascites fluid was aspirated from the abdomen of control and treated mice and the volume was quantified. Combined treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167663a398a0d4060d99d31fdcceadca
https://doi.org/10.1158/1078-0432.22476032
https://doi.org/10.1158/1078-0432.22476032
Autor:
Jim Petrik, Byram W. Bridle, Sarah K. Wootton, Jack Lawler, Pierre P. Major, Amanda W.K. AuYeung, Jacob P. van Vloten, Lisa A. Santry, Kathy Matuszewska
Purpose:Intravenous delivery of oncolytic viruses often leads to tumor vascular shutdown, resulting in decreased tumor perfusion and elevated tumor hypoxia. We hypothesized that using 3TSR to normalize tumor vasculature prior to administration of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70162777eeb068f616d113b8fa5e6f1e
https://doi.org/10.1158/1078-0432.c.6529271.v1
https://doi.org/10.1158/1078-0432.c.6529271.v1
Autor:
Grant McFadden, Jessica A. Minott, Thomas M. McAusland, Byram W. Bridle, Jacob P. van Vloten, Sarah K. Wootton, Lisa A. Santry, Jim Petrik, Joelle C. Ingrao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 434-447 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Poxviruses have been used extensively as vaccine vectors for human and veterinary medicine and have recently entered the clinical realm as immunotherapies for cancer. We present a comprehensive method for producing high-quality lots of the poxvirus P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8d0e1e714fba6be83931eefe8ea5e7
https://doi.org/10.1016/j.omtm.2021.08.004
https://doi.org/10.1016/j.omtm.2021.08.004