Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jacob Neeves"'
Autor:
Oliver J. Ziff, Jacob Neeves, Jamie Mitchell, Giulia Tyzack, Carlos Martinez-Ruiz, Raphaelle Luisier, Anob M. Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J. Boulton, Ammar Al-Chalabi, Gavin Kelly, Jack Humphrey, Rickie Patani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97% of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been hampered by disease heterogeneity and difficulties accessing motor neurons. Human i
Externí odkaz:
https://doaj.org/article/dd8f26a91a1646ca8fb84eb2c02762b3
Autor:
Darren Carwardine, Jonathan Prager, Jacob Neeves, Elizabeth M Muir, James Uney, Nicolas Granger, Liang-Fong Wong
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188967 (2017)
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate pro
Externí odkaz:
https://doaj.org/article/7a4624444c9146479006280844c95616
Autor:
Marija Petrić Howe, Hamish Crerar, Jacob Neeves, Jasmine Harley, Giulia E. Tyzack, Pierre Klein, Andres Ramos, Rickie Patani, Raphaëlle Luisier
Publikováno v:
Genome Research.
Intron retention (IR) is now recognized as a dominant splicing event during motor neuron (MN) development; however, the role and regulation of intron-retaining transcripts (IRTs) localized to the cytoplasm remain particularly understudied. Here we sh
Autor:
Oliver Ziff, Jacob Neeves, Jamie Mitchell, Guilia Tyzack, Carlos Ruiz, Nicholas McGranahan, Raphaelle Luisier, Anob Chakrabarti, Simon Boulton, Gavin Kelly, Jack Humphrey, Rickie Patani
Amyotrophic Lateral Sclerosis (ALS) is characterised by progressive motor neuron degeneration, but there is marked genetic and clinical heterogeneity1. It has been challenging to identify common ALS mechanisms among this diversity; however, a systema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac64cfbf4f356a9e904049e138fa2b77
https://doi.org/10.21203/rs.3.rs-2049501/v1
https://doi.org/10.21203/rs.3.rs-2049501/v1
Autor:
Oliver Ziff, Jacob Neeves, Simon Boulton, Giulia Tyzack, Gavin Kelly, Nicholas McGranahan, Rickie Patani
Amyotrophic Lateral Sclerosis (ALS) is characterised by progressive motor neuron degeneration but there is marked genetic and clinical heterogeneity1. Identifying common mechanisms of ALS amongst this diversity has been challenging, however, a system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cac081f454efd32a96ea616848dedb9b
https://doi.org/10.1101/2022.08.11.22278516
https://doi.org/10.1101/2022.08.11.22278516
Autor:
Raphaëlle Luisier, Rickie Patani, Hamish Crerar, Pierre Klein, Doaa M Taha, Giulia E. Tyzack, Oliver J. Ziff, Nicholas M. Luscombe, Jacob Neeves
Publikováno v:
Brain
We recently described aberrantly increased cytoplasmic SFPQ intron-retaining transcripts (IRTs) and concurrent SFPQ protein mislocalization as new hallmarks of amyotrophic lateral sclerosis (ALS). However, the generalizability and potential roles of
Autor:
Miha Modic, Jamie S. Mitchell, Jacob Neeves, Jernej Ule, Linda Greensmith, Raphaëlle Luisier, Doaa M Taha, Jia Newcombe, Ione Meyer, Giulia E. Tyzack, Rickie Patani, Nicholas M. Luscombe
Publikováno v:
Brain
See Vidal and Atkin (doi:10.1093/brain/awz256) for a scientific commentary on this article. ALS remains incurable due to an incomplete understanding of its molecular pathogenesis. Tyzack, Luisier et al. report that FUS protein, previously thought to
Autor:
Katherine M. Wilson, Teresa Niccoli, Linda Partridge, Pietro Fratta, Mercedes Pardo, Benedikt V. Holbling, Nicol Birsa, Lauren M. Gittings, Julia Bussmann, Annora Thoeng, Thomas G. Moens, Miranda C. Dyson, Adrian M. Isaacs, Magda L. Atilano, Jyoti S. Choudhary, Jacob Neeves, Lu Yu, Idoia Glaria, Erik Storkebaum
Publikováno v:
Acta Neuropathologica
Acta Neuropathol
Acta Neuropathologica, 137, 487-500
Acta Neuropathologica, 137, 3, pp. 487-500
Acta Neuropathol
Acta Neuropathologica, 137, 487-500
Acta Neuropathologica, 137, 3, pp. 487-500
A GGGGCC hexanucleotide repeat expansion within the C9orf72 gene is the most common genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia. Sense and antisense repeat-containing transcripts undergo repeat-associated non-AUG-i
Autor:
Oliver J. Ziff, Jacob Neeves, Anob M. Chakrabarti, Nicholas M. Luscombe, Gavin Kelly, Benjamin E. Clarke, Doaa M Taha, Rickie Patani, Hamish Crerar, Giulia E. Tyzack
Publikováno v:
Nucleic Acids Research
Reactive astrocytes are implicated in amyotrophic lateral sclerosis (ALS), although the mechanisms controlling reactive transformation are unknown. We show that decreased intron retention (IR) is common to human-induced pluripotent stem cell (hiPSC)-
Autor:
Jacob Neeves, Marija Petric-Howe, Raphaëlle Luisier, Giulia E. Tyzack, Hamish Crerar, Rickie Patani
SUMMARYIntron retention (IR) is now recognized as a dominant splicing event during motor neuron (MN) development, however the role and regulation of intron-retaining transcripts (IRTs) localized to the cytoplasm remain particularly understudied. By r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6cf4ce3504cec8f8617da35563a5391
https://doi.org/10.1101/2021.01.27.428555
https://doi.org/10.1101/2021.01.27.428555