Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jacob M. Tome"'
Autor:
Jing Luan, Guanjue Xiang, Pablo Aurelio Gómez-García, Jacob M. Tome, Zhe Zhang, Marit W. Vermunt, Haoyue Zhang, Anran Huang, Cheryl A. Keller, Belinda M. Giardine, Yu Zhang, Yemin Lan, John T. Lis, Melike Lakadamyali, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108783- (2021)
Summary: CCCTC-binding factor (CTCF) is a conserved zinc finger transcription factor implicated in a wide range of functions, including genome organization, transcription activation, and elongation. To explore the basis for CTCF functional diversity,
Externí odkaz:
https://doaj.org/article/043972196e1e41779878b3c99b1de8c7
Autor:
Jing Luan, Marit W. Vermunt, Camille M. Syrett, Allison Coté, Jacob M. Tome, Haoyue Zhang, Anran Huang, Jennifer M. Luppino, Cheryl A. Keller, Belinda M. Giardine, Shiping Zhang, Margaret C. Dunagin, Zhe Zhang, Eric F. Joyce, John T. Lis, Arjun Raj, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Nat Struct Mol Biol
Transcription at most promoters is divergent, initiating at closely spaced oppositely oriented core promoters to produce sense transcripts along with often unstable upstream antisense transcripts (uasTrx). How antisense transcription is regulated and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875560af4f05b41231d06865134f4090
https://europepmc.org/articles/PMC10015438/
https://europepmc.org/articles/PMC10015438/
Autor:
J Keller McKowen, Satya V S P Avva, Mukesh Maharjan, Fabiana M Duarte, Jacob M Tome, Julius Judd, Jamie L Wood, Sunday Negedu, Yunkai Dong, John T Lis, Craig M Hart
Publikováno v:
G3 Genes|Genomes|Genetics. 12
The Drosophila Boundary Element-Associated Factor of 32 kDa (BEAF) binds in promoter regions of a few thousand mostly housekeeping genes. BEAF is implicated in both chromatin domain boundary activity and promoter function, although molecular mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8479065813c2856530dd7fe1db5ae9
https://doi.org/10.1093/g3journal/jkac223
https://doi.org/10.1093/g3journal/jkac223
Autor:
Jing Luan, Camille M. Syrett, Marit W. Vermunt, Allison Coté, Jacob M. Tome, Haoyue Zhang, Anran Huang, Jennifer M. Luppino, Cheryl A. Keller, Belinda M. Giardine, Shiping Zhang, Margaret C. Dunagin, Zhe Zhang, Eric F. Joyce, John T. Lis, Arjun Raj, Ross C. Hardison, Gerd A. Blobel
Transcription at most promoters is divergent, initiating at closely spaced oppositely oriented core promoters to produce sense transcripts along with often unstable upstream antisense (uasTrx). How antisense transcription is regulated and to what ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b5d2708e4ba35a59ef68c44e45c293
https://doi.org/10.1101/2021.10.30.465508
https://doi.org/10.1101/2021.10.30.465508
Autor:
Yemin Lan, Haoyue Zhang, Yu Zhang, Marit W. Vermunt, Belinda Giardine, Jacob M Tome, Guanjue Xiang, Jing Luan, Pablo Aurelio Gómez-García, Cheryl A. Keller, Zhe Zhang, Gerd A. Blobel, John T. Lis, Anran Huang, Melike Lakadamyali, Ross C. Hardison
Publikováno v:
Cell reports
Cell Reports, Vol 34, Iss 8, Pp 108783-(2021)
Cell Reports, Vol 34, Iss 8, Pp 108783-(2021)
SUMMARY CCCTC-binding factor (CTCF) is a conserved zinc finger transcription factor implicated in a wide range of functions, including genome organization, transcription activation, and elongation. To explore the basis for CTCF functional diversity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74741760808e21d05f4d171f61abe8c0
http://hdl.handle.net/10230/52910
http://hdl.handle.net/10230/52910
Autor:
Diego Calderon, Anh Leith, Beth Martin, Andria Ellis, Riza M. Daza, Florence M. Chardon, Jacob M. Tome, Cole Trapnell, Wei Chen, Choli Lee, Jay Shendure
Gene regulation occurs through trans-acting factors (e.g. transcription factors) acting on cis-regulatory elements (e.g. enhancers). Massively parallel reporter assays (MPRAs) functionally survey large numbers of cis-regulatory elements for regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80793b6178dd9940fb3e4654b02fa538
https://doi.org/10.1101/2020.09.30.321323
https://doi.org/10.1101/2020.09.30.321323
Autor:
Chongyuan Luo, Xinmin Li, Leonid Kruglyak, Omai B. Garner, Jacob M. Tome, Evann E. Hilt, James Boocock, Yi Zhang, Sukantha Chandrasekaran, Yi Yin, Eleazar Eskin, Joshua S. Bloom, Valerie A. Arboleda, Laila Sathe, Shangxin Yang, Jay Shendure, Jonathan Flint, Sriram Kosuri, Longhua Guo
Author(s): Guo, Longhua; Boocock, James; Tome, Jacob; Chandrasekaran, Sukantha; Hilt, Evann; Zhang, Yi; Sathe, Laila; Li, Xinmin; Luo, Chongyuan; Kosuri, Sriram; Shendure, Jay; Arboleda, Valerie; Flint, Jonathan; Eskin, Eleazar; Garner, Omai; Yang, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::739a5f66e03d5fc6e363f429377ca33c
https://doi.org/10.1101/2020.08.15.252510
https://doi.org/10.1101/2020.08.15.252510
Publikováno v:
Nat Rev Genet
The human gene catalogue is essentially complete, but we lack an equivalently vetted inventory of bona fide human enhancers. Hundreds of thousands of candidate enhancers have been nominated via biochemical annotations; however, only a handful of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c49ae216928e4037dfe6b7fdda06af9
https://pubmed.ncbi.nlm.nih.gov/31988385
https://pubmed.ncbi.nlm.nih.gov/31988385
Autor:
Julius Judd, Luke A. Wojenski, Lauren M. Wainman, Nathaniel D. Tippens, Edward J. Rice, Alexis Dziubek, Geno J. Villafano, Erin M. Wissink, Philip Versluis, Lina Bagepalli, Sagar R. Shah, Dig B. Mahat, Jacob M. Tome, Charles G. Danko, John T. Lis, Leighton J. Core
Tracking active transcription with the nuclear run-on (NRO) assays has been instrumental in uncovering mechanisms of gene regulation. The coupling of NROs with high-throughput sequencing has facilitated the discovery of previously unannotated or unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a5d3292b6adc93373cb907a4ad84bb
https://doi.org/10.17504/protocols.io.57dg9i6
https://doi.org/10.17504/protocols.io.57dg9i6
Publikováno v:
Nature genetics
Eukaryotic RNA polymerase II (Pol II) has been found at both promoters and distal enhancers, suggesting additional functions beyond mRNA production. To understand this role, we sequenced nascent RNAs at single-molecule resolution to unravel the inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a26b333a436272f25a5ba26383ead7
https://pubmed.ncbi.nlm.nih.gov/30349116
https://pubmed.ncbi.nlm.nih.gov/30349116