Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jacob M. Remington"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Structure-based drug design targeting the SARS-CoV-2 virus has been greatly facilitated by available virus-related protein structures. However, there is an urgent need for effective, safe small-molecule drugs to control the spread of the vir
Externí odkaz:
https://doaj.org/article/2821bc4e151f414ba4c52588287f8f20
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The lack of biologically relevant protein structures can hinder rational design of small molecules to target G protein-coupled receptors (GPCRs). While ensemble docking using multiple models of the protein target is a promising technique for structur
Externí odkaz:
https://doaj.org/article/cf0dcf8afb874bad88fbd8103b278822
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The related neuropeptides PACAP and VIP, and their shared PAC1, VPAC1 and VPAC2 receptors, regulate a large array of physiological activities in the central and peripheral nervous systems. However, the lack of comparative and molecular mechanistic in
Externí odkaz:
https://doaj.org/article/50f2197f82304ab3b62f71c92c957025
Autor:
Xiaochuan Zhao, Umar F Shahul Hameed, Vladlena Kharchenko, Chenyi Liao, Franceline Huser, Jacob M Remington, Anand K Radhakrishnan, Mariusz Jaremko, Łukasz Jaremko, Stefan T Arold, Jianing Li
Publikováno v:
eLife, Vol 10 (2021)
The DNA-binding protein H-NS is a pleiotropic gene regulator in gram-negative bacteria. Through its capacity to sense temperature and other environmental factors, H-NS allows pathogens like Salmonella to adapt their gene expression to their presence
Externí odkaz:
https://doaj.org/article/3fd228bea29d480e96df7597f5c5d48b
Autor:
Jacob M Remington, Kyle T McKay, Noah B Beckage, Jonathon B Ferrell, Severin T. Schneebeli, Jianing Li
Publikováno v:
Journal of Computer-Aided Molecular Design. 37:147-156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3344fa0dca22ee0da193bf5c3cc3b1b
https://doi.org/10.1007/s10822-023-00497-2
https://doi.org/10.1007/s10822-023-00497-2
Autor:
Tuan Trinh, Ian Andrew Paul Thompson, Finley Clark, Jacob M. Remington, Michael Eisenstein, Jianing Li, Hyongsok Tom Soh
Publikováno v:
ACS Nano. 16:14549-14557
DNA switches that can change conformation in response to certain wavelengths of light could enable rapid and noninvasive control of chemical processes for a wide range of applications. However, most current photoresponsive DNA switches are limited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c21e5542243b7afc8cd6aaadddee38
https://doi.org/10.1021/acsnano.2c05010
https://doi.org/10.1021/acsnano.2c05010
Autor:
Muhammad Ghufran Rafique, Jacob M. Remington, Finley Clark, Haochen Bai, Violeta Toader, Dmytro F. Perepichka, Jianing Li, Hanadi F. Sleiman
Publikováno v:
Angewandte Chemie International Edition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00799183cdb080dba1ef82c1f98b277a
https://doi.org/10.1002/anie.202217814
https://doi.org/10.1002/anie.202217814
Publikováno v:
Journal of Chemical Education. 99:639-645
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f7958efdc3255e77df71c247e3be38
https://doi.org/10.1021/acs.jchemed.1c00691
https://doi.org/10.1021/acs.jchemed.1c00691
Autor:
Jacob M. Remington, Violeta Toader, Hanadi F. Sleiman, Jianing Li, Xin Luo, Michael D. Dore, Tuan Trinh, Marlo L. Zorman, Donatien de Rochambeau, Pengfei Xu, Casey M. Platnich, Gonzalo Cosa
Publikováno v:
Chem. 7:2395-2414
Summary DNA nanostructures are highly addressable and compatible with biological systems but often require hundreds of unique strands for their assembly. On the other hand, nature can assemble complex structures from identical building blocks by comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b0dfaac551ec4555f6467b40994b01
https://doi.org/10.1016/j.chempr.2021.05.022
https://doi.org/10.1016/j.chempr.2021.05.022
Publikováno v:
J Phys Chem Lett
The histone-like nucleoid structuring (H-NS) protein controls the expression of hundreds of genes in Gram-positive bacteria through its capability to coat and condense DNA. This mechanism requires the formation of superhelical H-NS protein filaments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abc97cfac4d276aad435a95f061fbf7
https://doi.org/10.1021/acs.jpclett.1c01710
https://doi.org/10.1021/acs.jpclett.1c01710