Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jacob M. Janey"'
Autor:
Benjamin D. Ravetz, Nicholas E. S. Tay, Candice L. Joe, Melda Sezen-Edmonds, Michael A. Schmidt, Yichen Tan, Jacob M. Janey, Martin D. Eastgate, Tomislav Rovis
Publikováno v:
ACS Central Science, Vol 6, Iss 11, Pp 2053-2059 (2020)
Externí odkaz:
https://doaj.org/article/ebd103db835d4d43ad8403dc5d0818e5
Autor:
Yong-Li Zhong, C. Scott Shultz, Jacob M. Janey, Yonggang Chen, Birgit Kosjek, Lushi Tan, Jeffrey C. Moore, Michael Shevlin
Publikováno v:
The Journal of Organic Chemistry. 87:2120-2128
Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the stereochemistry relied on either chiral rhodium catalyst-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4280b753a165445efd097582eba7cf
https://doi.org/10.1021/acs.joc.1c01795
https://doi.org/10.1021/acs.joc.1c01795
Autor:
Ryan P. Adams, Marvin Parasram, Jacob M. Janey, Jason M. Stevens, Benjamin J. Shields, Abigail G. Doyle, Jesus I. Martinez Alvarado, Jun Li, Farhan Damani
Publikováno v:
Nature. 590:89-96
Reaction optimization is fundamental to synthetic chemistry, from optimizing the yield of industrial processes to selecting conditions for the preparation of medicinal candidates1. Likewise, parameter optimization is omnipresent in artificial intelli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7235dbb2d79ff3ce79c6621bcc41806
https://doi.org/10.1038/s41586-021-03213-y
https://doi.org/10.1038/s41586-021-03213-y
Publikováno v:
Organic Process Research & Development. 24:2722-2727
This report is a follow-up to our two prior publications that analyzed solubility behaviors and correlations of common solvents. The statistical results reported herein, on a large number of common...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0f95eb391a04c2c63a679516115d5a1
https://doi.org/10.1021/acs.oprd.0c00387
https://doi.org/10.1021/acs.oprd.0c00387
Autor:
Tomislav Rovis, Candice L. Joe, Yichen Tan, Nicholas E. S. Tay, Michael A. Schmidt, Benjamin D. Ravetz, Jacob M. Janey, Martin D. Eastgate, Melda Sezen-Edmonds
Publikováno v:
ACS Central Science
ACS Central Science, Vol 6, Iss 11, Pp 2053-2059 (2020)
ACS Central Science, Vol 6, Iss 11, Pp 2053-2059 (2020)
Over the past decade, chemists have embraced visible-light photoredox catalysis due to its remarkable ability to activate small molecules. Broadly, these methods employ metal complexes or organic dyes to convert visible light into chemical energy. Un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3b954b3fbcfdc8b955cc3e72e1d328
http://europepmc.org/articles/PMC7706074
http://europepmc.org/articles/PMC7706074
Publikováno v:
Organic Process Research & Development. 24:2702-2708
Through a statistical analysis of empirical solubility data collected from over 1,000 solutes, the solubility behaviors of 53 common solvents are characterized in two different dimensions: classifi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20cd86edb8e8dc12294fc818f534088c
https://doi.org/10.1021/acs.oprd.0c00364
https://doi.org/10.1021/acs.oprd.0c00364
Autor:
Jacob M. Janey
Publikováno v:
Chem. 7:1151-1153
Solubility measurements are critical to the development of any chemical process. Recently in iScience, Shiri et al. describe a modular, "human-out-of-the-loop" platform that uses visual data rather than typical analytical techniques such as high-perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ec4661537a551788055cd51ebe50e18
https://doi.org/10.1016/j.chempr.2021.04.007
https://doi.org/10.1016/j.chempr.2021.04.007
Publikováno v:
Organic Process Research & Development. 23:1343-1351
We explain the concept of solubility synergistic solvation (also known as parabolic solubility), wherein a binary solvent mixture exhibits a higher solubility than either of the component solvents ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::198b4b2cf3a6083e126f0fc2beedfaef
https://doi.org/10.1021/acs.oprd.9b00077
https://doi.org/10.1021/acs.oprd.9b00077
Autor:
Andrew D. Campbell, Rubén Haro, Thomas Andrew Brandt, Melodie Christensen, David B. Damon, Ke Wang, Carolina Alhambra, Paul C. Lobben, Jacob M. Janey, J. Eugenio de Diego, Ling Li, Iulia I. Strambeanu, Susana García-Cerrada, Javier Magano, Emma McInturff, Steven M. Mennen, Jack Twilton, David W. C. MacMillan, Fangfang Liu, Jesús Castañón, Matthew A. Zajac, Pablo Garcia-Losada, Sebastien Monfette, Mario Barberis, Alan H. Cherney, Jason M. Stevens, Barbara J. Sitter, Danielle M. Schultz, Ronald J. Post, Simon Berritt, C. Liana Allen, David C. Leitch
Publikováno v:
Organic Process Research & Development. 23:1213-1242
High-throughput experimentation (HTE) has revolutionized the pharmaceutical industry, most notably allowing for rapid screening of compound libraries against therapeutic targets. The past decade ha...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d057d4265eaefcd550f067f2a336489
https://doi.org/10.1021/acs.oprd.9b00140
https://doi.org/10.1021/acs.oprd.9b00140
Publikováno v:
Reaction Chemistry & Engineering. 4:1646-1657
The combination of parallel, automation technologies with increasingly sophisticated modeling and statistical techniques has greatly accelerated the ability of pharmaceutical process research and development groups to understand and develop robust, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbe19353f7e561687b690cd9460567b0
https://doi.org/10.1039/c9re00079h
https://doi.org/10.1039/c9re00079h