Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Jacob M van Laar"'
Autor:
Jacob M van Laar, Linda Mathsson-Alm, Tammo Brunekreef, Jorge Dias, Henny Otten, Saskia Haitjema, Imo Hoefer, Rowena Melchers
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/0db1c67062fe4be682b696b4d37edd80
Autor:
Ellen De Langhe, Jacob M van Laar, Alexandre E Voskuyl, Madelon C Vonk, Roger Hesselstrand, Dirk M Wuttge, Reinhard E Voll, Arjan A van de Loosdrecht, Julia Spierings, Joerg Henes, Anna van Rhenen, Paco MW Welsing, Anne CA Marijnissen, Daan Dierickx, Karina R Gheorghe, Tessa Kerre, Erik WAF Marijt, Miro Mayer, Marc Schmalzing, Roland Schroers
Publikováno v:
BMJ Open, Vol 11, Iss 3 (2021)
Introduction Systemic sclerosis (SSc) is a chronic, autoimmune connective tissue disease associated with high morbidity and mortality, especially in diffuse cutaneous SSc (dcSSc). Currently, there are several treatments available in early dcSSc that
Externí odkaz:
https://doaj.org/article/4a838e7f1e5341d79e7ae951942a0f36
Autor:
Xavier M Teitsma, Wei Yang, Johannes W G Jacobs, Attila Pethö-Schramm, Michelle E A Borm, Amy C Harms, Thomas Hankemeier, Jacob M van Laar, Johannes W J Bijlsma, Floris P J G Lafeber
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background We previously identified, in newly diagnosed rheumatoid arthritis (RA) patients, networks of co-expressed genes and proteomic biomarkers associated with achieving sustained drug-free remission (sDFR) after treatment with tocilizum
Externí odkaz:
https://doaj.org/article/923d9bb128b44553be1161301bed5ce1
Autor:
Gillian Wheater, Mohsen Elshahaly, Kamran Naraghi, Stephen P Tuck, Harish K Datta, Jacob M van Laar
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201527 (2018)
Data describing the effect of in vivo B cell depletion on general bone loss in patients with rheumatoid arthritis (RA) are limited. Given the pathogenetic role of B cells in RA, it is tempting to speculate that B cell depletion might have a beneficia
Externí odkaz:
https://doaj.org/article/ce5942ed607d42678475fab927567b30
Autor:
Bart V J Cuppen, Junzeng Fu, Herman A van Wietmarschen, Amy C Harms, Slavik Koval, Anne C A Marijnissen, Judith J W Peeters, Johannes W J Bijlsma, Janneke Tekstra, Jacob M van Laar, Thomas Hankemeier, Floris P J G Lafeber, Jan van der Greef, all Society for Rheumatology Research Utrecht investigators
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163087 (2016)
In clinical practice, approximately one-third of patients with rheumatoid arthritis (RA) respond insufficiently to TNF-α inhibitors (TNFis). The aim of the study was to explore the use of a metabolomics to identify predictors for the outcome of TNFi
Externí odkaz:
https://doaj.org/article/1c5af5e543fb448dae67a75eafceb2bc
Autor:
Marina D Kraaij, Jacob M van Laar
Publikováno v:
Biologics: Targets & Therapy, Vol 2008, Iss Issue 3, Pp 389-395 (2008)
Marina D Kraaij, Jacob M van LaarMusculoskeletal Research Group, Institute of Cellular Medicine, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United KingdomAbstract: Systemic sclerosis (SSc) is a connective
Externí odkaz:
https://doaj.org/article/46c836f8b47a412cb29857b060282931
Autor:
Marzena Ciechomska, Steven O'Reilly, Monika Suwara, Katarzyna Bogunia-Kubik, Jacob M van Laar
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115596 (2014)
Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by skin and internal organs fibrosis due to accumulation of extra cellular matrix (ECM) proteins. Tissue inhibitor of metalloproteinases 1 (TIMP-1) plays a key role in
Externí odkaz:
https://doaj.org/article/698c5312c9ef4c3dbc2b9218120a36fe
Autor:
F David Carmona, Jose-Ezequiel Martin, Lorenzo Beretta, Carmen P Simeón, Patricia E Carreira, José Luis Callejas, Mónica Fernández-Castro, Luis Sáez-Comet, Emma Beltrán, María Teresa Camps, María Victoria Egurbide, Spanish Scleroderma Group, Paolo Airó, Raffaella Scorza, Claudio Lunardi, Nicolas Hunzelmann, Gabriela Riemekasten, Torsten Witte, Alexander Kreuter, Jörg H W Distler, Rajan Madhok, Paul Shiels, Jacob M van Laar, Carmen Fonseca, Christopher Denton, Ariane Herrick, Jane Worthington, Annemie J Schuerwegh, Madelon C Vonk, Alexandre E Voskuyl, Timothy R D J Radstake, Javier Martín
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54419 (2013)
Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory
Externí odkaz:
https://doaj.org/article/afa8ae7b7ebd4fc38220c9d307612f84
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33508 (2012)
BACKGROUND: Circulating monocytes are a highly plastic and functionally heterogeneic cell type with an activated phenotype in patients with systemic sclerosis (SSc). CD14(+) monocytes have the potential to differentiate into extra-cellular matrix (EC
Externí odkaz:
https://doaj.org/article/2a11e188798c4991b67192a2b1eba8a9
Autor:
Chiara Tani, Chiara Cardelli, Roberto Depascale, Anna Gamba, Luca Iaccarino, Andrea Doria, Matilde Bandeira, Sara Paiva Dinis, Vasco C. Romão, Emanuele Gotelli, Sabrina Paolino, Maurizio Cutolo, Niccolò Di Giosaffatte, Alessandro Ferraris, Paola Grammatico, Lorenzo Cavagna, Veronica Codullo, Carlomaurizio Montecucco, Valentina Longo, Lorenzo Beretta, Ilaria Cavazzana, Micaela Fredi, Silvia Peretti, Serena Guiducci, Marco Matucci-Cerinic, Stefano Bombardieri, Gerd R. Burmester, João E. Fonseca, Charissa Frank, Ilaria Galetti, Eric Hachulla, Ulf Müller-Ladner, Matthias Schneider, Vanessa Smith, Farah Tamirou, Jacob M. Van Laar, Ana Vieira, Rossella D'Urzo, Sara Cannizzo, Andrea Gaglioti, Diana Marinello, Rosaria Talarico, Marta Mosca
Publikováno v:
Journal of Translational Autoimmunity, Vol 7, Iss , Pp 100221- (2023)
Background: Vaccination is one of the most important measures to contain the COVID-19 pandemic, especially for frail patients. VACCINATE is a multicentre prospective observational study promoted by the European Reference Network on Rare and Complex C
Externí odkaz:
https://doaj.org/article/6535028b21df4f64b471e8d7b7b6052c