Zobrazeno 1 - 10
of 262
pro vyhledávání: '"Jacob M van Laar"'
Autor:
Jacob M van Laar, Anna de Goede, Gerty Schreibelt, Arie Jan Stoppelenburg, I Jolanda M de Vries, Paco Welsing, Bouke Koeneman, Evert-Jan Breman, Laureen Lammers, Tjitske Duiveman-de Boer, Willem van Eden, Paul Leufkens, Femke Broere
Publikováno v:
BMJ Open, Vol 14, Iss 9 (2024)
Introduction In rheumatoid arthritis (RA), immunosuppressive therapies may achieve symptomatic relief, but do not induce long-term, drug-free remission. Meanwhile, the lifelong use of immunosuppressive drugs confers increased risk for malignancy and
Externí odkaz:
https://doaj.org/article/048d163ecbc2444592ca57a8e33b4efc
Autor:
Jacob M van Laar, Linda Mathsson-Alm, Tammo Brunekreef, Maarten Limper, Jorge Dias, Henny Otten, Saskia Haitjema, Imo Hoefer, Rowena Melchers
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss 1 (2021)
Objective Many autoantibodies are known to be associated with SLE, although their role in clinical practice is limited because of low sensitivity and weak associations with clinical manifestations. There has been great interest in the discovery of ne
Externí odkaz:
https://doaj.org/article/0db1c67062fe4be682b696b4d37edd80
Autor:
Désirée van der Heijde, Paco M J Welsing, Jacob M van Laar, Nadia M T Roodenrijs, György Nagy, Melinda Kedves, Attila Hamar
Publikováno v:
RMD Open, Vol 7, Iss 1 (2021)
Objectives To summarise, by a systematic literature review (SLR), the evidence regarding pharmacological and non-pharmacological therapeutic strategies in difficult-to-treat rheumatoid arthritis (D2T RA), informing the EULAR recommendations for the m
Externí odkaz:
https://doaj.org/article/fa4ec8a3c6584cb89fc1fc554c4714be
Autor:
Désirée van der Heijde, Paco M J Welsing, Jacob M van Laar, Nadia M T Roodenrijs, György Nagy, Melinda Kedves, Attila Hamar
Publikováno v:
RMD Open, Vol 7, Iss 1 (2021)
Objectives To summarise the evidence on diagnostic issues in difficult-to-treat rheumatoid arthritis (D2T RA) informing the EULAR recommendations for the management of D2T RA.Methods A systematic literature review (SLR) was performed regarding the op
Externí odkaz:
https://doaj.org/article/0788f3f975e64428af8d55cff8024176
Autor:
Vanessa Smith, Ellen De Langhe, Jacob M van Laar, Alexandre E Voskuyl, Madelon C Vonk, Roger Hesselstrand, Ulrich A Walker, Dirk M Wuttge, Reinhard E Voll, Arjan A van de Loosdrecht, Julia Spierings, Joerg Henes, Anna van Rhenen, Paco MW Welsing, Anne CA Marijnissen, Nicoletta Del Papa, Daan Dierickx, Karina R Gheorghe, Tessa Kerre, Per Ljungman, Erik WAF Marijt, Miro Mayer, Marc Schmalzing, Roland Schroers, Jeska K de Vries-Bouwstra
Publikováno v:
BMJ Open, Vol 11, Iss 3 (2021)
Introduction Systemic sclerosis (SSc) is a chronic, autoimmune connective tissue disease associated with high morbidity and mortality, especially in diffuse cutaneous SSc (dcSSc). Currently, there are several treatments available in early dcSSc that
Externí odkaz:
https://doaj.org/article/4a838e7f1e5341d79e7ae951942a0f36
Autor:
Rosaria Talarico, Frederic Houssiau, Stefano Bombardieri, Gerd Burmester, Ilaria Galetti, Eric Hachulla, Ulf Mueller-Ladner, Matthias Schneider, Vanessa Smith, Maurizio Cutolo, Marta Mosca, Jacob M van Laar, Charissa Frank, Ana Vieira, Giuseppe Turchetti, Joao Fonseca, Diana Marinello
Publikováno v:
RMD Open, Vol 6, Iss 2 (2020)
Introduction The European Reference Network (ERN) ReCONNET is the ERN aimed at improving the management of rare and complex connective tissue and musculoskeletal diseases (rCTDs) across the European Union (EU). In the mission of ERN ReCONNET, clinica
Externí odkaz:
https://doaj.org/article/150458132ac547a4b417f1b84f1cd975
Autor:
Xavier M Teitsma, Wei Yang, Johannes W G Jacobs, Attila Pethö-Schramm, Michelle E A Borm, Amy C Harms, Thomas Hankemeier, Jacob M van Laar, Johannes W J Bijlsma, Floris P J G Lafeber
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background We previously identified, in newly diagnosed rheumatoid arthritis (RA) patients, networks of co-expressed genes and proteomic biomarkers associated with achieving sustained drug-free remission (sDFR) after treatment with tocilizum
Externí odkaz:
https://doaj.org/article/923d9bb128b44553be1161301bed5ce1
Autor:
Gillian Wheater, Mohsen Elshahaly, Kamran Naraghi, Stephen P Tuck, Harish K Datta, Jacob M van Laar
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201527 (2018)
Data describing the effect of in vivo B cell depletion on general bone loss in patients with rheumatoid arthritis (RA) are limited. Given the pathogenetic role of B cells in RA, it is tempting to speculate that B cell depletion might have a beneficia
Externí odkaz:
https://doaj.org/article/ce5942ed607d42678475fab927567b30
Autor:
Bart V J Cuppen, Junzeng Fu, Herman A van Wietmarschen, Amy C Harms, Slavik Koval, Anne C A Marijnissen, Judith J W Peeters, Johannes W J Bijlsma, Janneke Tekstra, Jacob M van Laar, Thomas Hankemeier, Floris P J G Lafeber, Jan van der Greef, all Society for Rheumatology Research Utrecht investigators
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163087 (2016)
In clinical practice, approximately one-third of patients with rheumatoid arthritis (RA) respond insufficiently to TNF-α inhibitors (TNFis). The aim of the study was to explore the use of a metabolomics to identify predictors for the outcome of TNFi
Externí odkaz:
https://doaj.org/article/1c5af5e543fb448dae67a75eafceb2bc
Autor:
Marina D Kraaij, Jacob M van Laar
Publikováno v:
Biologics: Targets & Therapy, Vol 2008, Iss Issue 3, Pp 389-395 (2008)
Marina D Kraaij, Jacob M van LaarMusculoskeletal Research Group, Institute of Cellular Medicine, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United KingdomAbstract: Systemic sclerosis (SSc) is a connective
Externí odkaz:
https://doaj.org/article/46c836f8b47a412cb29857b060282931