Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Jacob M Hiller"'
Autor:
Jacob M. Hiller, Natasa Ancevska-Taneva, Irma Onoprishvili, Hal K. Kramer, Matthew L. Andria, Eric J. Simon
Publikováno v:
Molecular Pharmacology. 64:1092-1100
The carboxyl tail of the human mu opioid receptor was shown to bind the carboxyl terminal region of human filamin A, a protein known to couple membrane proteins to actin. Results from yeast two-hybrid screening were confirmed by direct protein-protei
Publikováno v:
Journal of Neurochemistry. 65:2537-2542
A mu-opioid receptor protein (mu-ORP) purified to homogeneity from bovine striatal membranes has been functionally reconstituted in liposomes with highly purified heterotrimeric guanine nucleotide regulatory proteins (G proteins). A mixture of bovine
Publikováno v:
Molecular Brain Research. 73:129-137
The cDNA coding for the bovine mu-opioid receptor has been cloned and sequenced. Conserved sequences from murine delta-receptor cDNA were used as primers in polymerase chain reaction (PCR) to amplify cDNA, prepared by reverse transcription of bovine
Publikováno v:
Neurochemical Research. 24:37-42
We have investigated the role of cysteine residues in a highly purified mu opioid receptor protein (muORP) by examining the effect of -SH reagents on the binding of opioid ligands. Treatment of muORP, which is devoid of additional proteins, eliminate
Autor:
George K Ehrlich, Matthew L Andria, Xin Zheng, Brigitte Kieffer, Theresa L Gioannini, Jacob M Hiller, Jeremy E Rosenkranz, Boris M Veksler, R Suzanne Zukin, Eric J Simon
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 76:269-277
Previous work suggested that sulfhydryl groups and disulfide bridges have important functions in opioid binding to the delta opioid receptor. The question regarding which cysteines are essential for ligand binding was approached by replacement of cys
Publikováno v:
Analgesia. 1:457-460
Publikováno v:
Anesthesia & Analgesia. 80:92-96
This study was designed to determine whether systemic absorption plays any role in the antinociceptive effect of epidural (EP) sodium S(+)-ibuprofen (IB). One week after surgical implantation of EP catheters, six rabbits were given EP injections with
Publikováno v:
Brain Research. 656:274-280
It was previously observed that chronic food restriction lowers the threshold for lateral hypothalamic self-stimulation in a manner that is reversible by mu- and kappa-selective opioid antagonists. The present quantitative autoradiographic study was
Publikováno v:
Proceedings of the National Academy of Sciences. 89:52-55
A mu opioid binding protein (OBP), previously purified to homogeneity from bovine striatal membranes, was examined by immunoblotting with six antisera against bovine rhodopsin. An antibody against the carboxyl-terminal tail of rhodopsin and one again
Publikováno v:
Brain research. 1081(1)
A yeast two-hybrid screen, using the carboxyl tail of the human mu opioid receptor as bait and a human brain cDNA library as target, indicated that the carboxyl terminal portion of hlj1, a member of the human heat shock protein 40 family, interacts w