Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jacob M, Goldberg"'
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Small-molecule fluorescent probes are powerful and ubiquitous tools for measuring the concentration and distribution of analytes in living cells. However, accurate characterization of these analytes requires rigorous evaluation of cell-to-ce
Externí odkaz:
https://doaj.org/article/852635636b5e4591bccbb61e1037cb31
Autor:
Jacob M. Goldberg, Stephen J. Lippard
Publikováno v:
FEBS letters.
Mobile zinc is an abundant transition metal ion in the central nervous system, with pools of the ion accumulating in regions of the brain engaged in sensory perception and memory formation. Here we present essential tools that we developed to interro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b423134755e4928381b605f34244cb
https://pubmed.ncbi.nlm.nih.gov/36416529
https://pubmed.ncbi.nlm.nih.gov/36416529
Autor:
Bradley M. Lipka, Vincent M. Betti, Daniel S. Honeycutt, Daniel L. Zelmanovich, Max Adamczyk, Ruojun Wu, Harrison S. Blume, Caitlin A. Mendina, Jacob M. Goldberg, Fang Wang
Publikováno v:
Bioconjugate chemistry. 33(11)
Here, we present a series of fluorinated cationic reagents that enable rapid arylation of cysteine under mild conditions compatible with proteins and peptides. The highly polarized C-F bond and attractive nucleophile-electrophile Coulombic interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f014d3f35340d1ada22053b05ceebf
https://pubmed.ncbi.nlm.nih.gov/36335596
https://pubmed.ncbi.nlm.nih.gov/36335596
Publikováno v:
J Neurosci
In many brain areas, such as the neocortex, limbic structures, and auditory brainstem, synaptic zinc is released from presynaptic terminals to modulate neurotransmission. As such, synaptic zinc signaling modulates sensory processing and enhances acui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fefe49b5c33786a94d5e59816091b3c
https://doi.org/10.1523/jneurosci.0175-20.2020
https://doi.org/10.1523/jneurosci.0175-20.2020
Autor:
Jonnell Candice Small, Rohit N. Kulkarni, Basudeb Maji, Miseon Lee, Stephen J. Lippard, Debasish Manna, Jacob M. Goldberg, Sevim Kahraman, Praveen Kokkonda, Ruth M. Elgamal, Amedeo Vetere, Bridget K. Wagner, Amit Choudhary
Publikováno v:
Journal of the American Chemical Society
The loss of insulin-producing β-cells is the central pathological event in type 1 and 2 diabetes, which has led to efforts to identify molecules to promote β-cell proliferation, protection, and imaging. However, the lack of β-cell specificity of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67c20500e2dfa85118cdda3f5fdcccd
https://doi.org/10.1021/jacs.0c00099
https://doi.org/10.1021/jacs.0c00099
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Phenol soluble modulins (PSMs) are an important class of peptides secreted by Staphylococcus aureus bacteria. The toxicity to human cells and unique ability of one such peptide, PSMα3, to aggregate into an α-helical amyloid-like struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94569587853c0a315c9c916eedcc2f90
https://doi.org/10.1073/pnas.2114923119
https://doi.org/10.1073/pnas.2114923119
The formation of ordered cross-β amyloid protein aggregates is associated with a variety of human disorders. While conventional infrared methods serve as sensitive reporters of the presence of these amyloids, the recently discovered amyloid secondar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d120bb79fb93a50c844dd0989f445818
https://doi.org/10.33774/chemrxiv-2021-3bllg-v2
https://doi.org/10.33774/chemrxiv-2021-3bllg-v2
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Scientific Reports
Small-molecule fluorescent probes are powerful and ubiquitous tools for measuring the concentration and distribution of analytes in living cells. However, accurate characterization of these analytes requires rigorous evaluation of cell-to-cell hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c4331416a352d4a280b43762bad66e
https://doaj.org/article/852635636b5e4591bccbb61e1037cb31
https://doaj.org/article/852635636b5e4591bccbb61e1037cb31
Autor:
Martin Rahm, Chanan D. Sessler, Fang Wang, Stephen J. Lippard, Jacob M. Goldberg, Sabine Becker
Publikováno v:
Journal of the American Chemical Society. 139:9325-9332
The CF2H group, a potential surrogate for the OH group, can act as an unusual hydrogen bond donor, as confirmed by crystallographic, spectroscopic, and computational methods. Here, we demonstrate the bioisosterism of the OH and CF2H groups and the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f4e21979979277c8c7a46fdfa5ce9ff
https://doi.org/10.1021/jacs.7b04457
https://doi.org/10.1021/jacs.7b04457
Publikováno v:
Israel Journal of Chemistry. 56:791-802
Metal ions perform critical and diverse functions in nervous system physiology and pathology. The field of metalloneurochemistry aims to understand the mechanistic bases for these varied roles at the molecular level. Here, we review several areas of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf2514333da24ca9ad5dbecdd9fcd6f
https://doi.org/10.1002/ijch.201600034
https://doi.org/10.1002/ijch.201600034