Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jacob Leflein"'
Autor:
Diane M. Simeone, Mats E. Ljungman, Monica Liebert, Yair Lotan, Xue-Ru Wu, Lakshmi. P. Kunju, Stephanie Daignault, Scott A. Tomlins, Gina M. Ney, Chandan Kumar-Sinha, John E. Wilkinson, McKenzie L. Ahmet, Jacob Leflein, Yin Wang, Huibin Yang, Lidong Wang, Phillip L. Palmbos
Bladder cancer is a common and deadly malignancy but its treatment has advanced little due to poor understanding of the factors and pathways that promote disease. ATDC/TRIM29 is a highly expressed gene in several lethal tumor types, including bladder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11dd42a8239bd2eb8522c0d2bdc10072
https://doi.org/10.1158/0008-5472.c.6507119.v1
https://doi.org/10.1158/0008-5472.c.6507119.v1
Autor:
Diane M. Simeone, Mats E. Ljungman, Monica Liebert, Yair Lotan, Xue-Ru Wu, Lakshmi. P. Kunju, Stephanie Daignault, Scott A. Tomlins, Gina M. Ney, Chandan Kumar-Sinha, John E. Wilkinson, McKenzie L. Ahmet, Jacob Leflein, Yin Wang, Huibin Yang, Lidong Wang, Phillip L. Palmbos
Supplemental Figure 1. ATDC mRNA expression in normal littermate (N) or CAG-ATDC transgenic bladders Supplemental Figure 2. Bladder urothelial lesions in CAG-ATDC transgenic line A of 8-12 months of age. Supplemental Figure 3. ATDC mRNA levels in CAG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d6bdb8fe24157a15c73074c60842bd
https://doi.org/10.1158/0008-5472.22406588
https://doi.org/10.1158/0008-5472.22406588
Autor:
Ethan V. Abel, Alan J Kelleher, Erica R. Gumkowski, Guadalupe Lorenzatti Hiles, Armand Bankhead, Mark L. Day, Mats Ljungman, Phillip L. Palmbos, Jacob Leflein, McKenzie L. Ahmet, Michele L. Dziubinski, Samuel D. Welling, Huibin Yang, Diane M. Simeone, Yin Wang, Brian Magnuson, Sumithra Urs, Lidong Wang
Publikováno v:
Oncogene
Basal subtype cancers are deadly malignancies but the molecular events driving tumor lethality are not completely understood. Ataxia-telangiectasia group D complementing gene (ATDC, also known as TRIM29), is highly expressed and drives tumor formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e4f19e79c89d1fd9175dbdb137e613
https://doi.org/10.1038/s41388-018-0646-9
https://doi.org/10.1038/s41388-018-0646-9
Autor:
Gina Ney, Phillip L. Palmbos, Scott R. Owens, Jayendra Prasad, Mats Ljungman, Marina Pasca di Magliano, Andrew D. Rhim, Filip Bednar, Huibin Yang, Ethan V. Abel, Meghna Waghray, Lidong Wang, Jacob Leflein, Yaqing Zhang, Diane M. Simeone, John E. Wilkinson
Publikováno v:
Genes & Development. 29:171-183
The initiation of pancreatic ductal adenocarcinoma (PDA) is linked to activating mutations in KRAS. However, in PDA mouse models, expression of oncogenic mutant KRAS during development gives rise to tumors only after a prolonged latency or following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952ff9d452eeacffe6954142be1bce06
https://doi.org/10.1101/gad.253591.114
https://doi.org/10.1101/gad.253591.114
Autor:
Lidong Wang, Lakshmi P. Kunju, Huibin Yang, Monica Liebert, Yin Wang, Gina Ney, Jacob Leflein, Mats Ljungman, McKenzie L. Ahmet, Xue-Ru Wu, Diane M. Simeone, John E. Wilkinson, Yair Lotan, Stephanie Daignault, Scott A. Tomlins, Phillip L. Palmbos, Chandan Kumar-Sinha
Publikováno v:
Cancer research. 75(23)
Bladder cancer is a common and deadly malignancy but its treatment has advanced little due to poor understanding of the factors and pathways that promote disease. ATDC/TRIM29 is a highly expressed gene in several lethal tumor types, including bladder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a3ea1ea46bb407c502ed868c538cf1
https://pubmed.ncbi.nlm.nih.gov/26471361
https://pubmed.ncbi.nlm.nih.gov/26471361
Autor:
Jayendra Prasad, Mary A. Davis, Diane M. Simeone, Huibin Yang, Taylor Detzler, Theodore S. Lawrence, Jacob Leflein, Liang Xu, Phillip L. Palmbos, Mats Ljungman, Dawn M. Coleman, Min Zhang, Corey M. Helchowski, J. Kevin Hicks, Wenhua Tang, Lidong Wang, Xiaochun Yu, Gina Ney, Christine E. Canman
Publikováno v:
Cancer research. 74(6)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by therapeutic resistance for which the basis is poorly understood. Here, we report that the DNA and p53-binding protein ATDC/TRIM29, which is highly expressed in PDAC, plays a critical role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd85d6cc02587d99dc0156dc7419c0de
https://pubmed.ncbi.nlm.nih.gov/24469230
https://pubmed.ncbi.nlm.nih.gov/24469230
Autor:
Gina Ney, Marina Pasca di Magliano, Jacob Leflein, Diane M. Simeone, Huibin Yang, Taylor Detzler, Filip Bednar, Lidong Wang, Yaqing Zhang
Publikováno v:
Tumor Biology.
Background: Pancreatic ductal adeno-carcinoma (PDAC) ranks among the most lethal of human malignancies. We have demonstrated that ATDC is overexpressed in PDAC and promotes pancreatic cancer growth by activation of Wnt/β-catenin signaling (Cancer Ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f379b5bf3e37f35cff952d5940c11b0c
https://doi.org/10.1158/1538-7445.panca2012-b49
https://doi.org/10.1158/1538-7445.panca2012-b49