Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jacob Lahr"'
Autor:
Michael Single, Lena C. Bruhin, Aaron Colombo, Kevin Möri, Stephan M. Gerber, Jacob Lahr, Paul Krack, Stefan Klöppel, René M. Müri, Urs P. Mosimann, Tobias Nef
Publikováno v:
Sensors, Vol 24, Iss 4, p 1172 (2024)
Gait abnormalities in older adults are linked to increased risks of falls, institutionalization, and mortality, necessitating accurate and frequent gait assessments beyond traditional clinical settings. Current methods, such as pressure-sensitive wal
Externí odkaz:
https://doaj.org/article/8f311a07c8a940df9e72c6f2b765392b
Autor:
Jessica Peter, Isabella Mayer, Thomas Kammer, Lora Minkova, Jacob Lahr, Stefan Klöppel, Michel J. Grothe, Michael Orth
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract We assessed the structure–function relationship of the human cholinergic system and hypothesized that structural measures are associated with short-latency sensory afferent inhibition (SAI), an electrophysiological measure of central choli
Externí odkaz:
https://doaj.org/article/14a640e78bd34437a2d0eb958651d24e
Autor:
Stefan Klöppel, Shan Yang, Elias Kellner, Marco Reisert, Bernhard Heimbach, Horst Urbach, Jennifer Linn, Stefan Weidauer, Tamara Andres, Maximilian Bröse, Jacob Lahr, Niklas Lützen, Philipp T. Meyer, Jessica Peter, Ahmed Abdulkadir, Sabine Hellwig, Karl Egger
Publikováno v:
NeuroImage: Clinical, Vol 20, Iss , Pp 851-860 (2018)
The identification of pathological atrophy in MRI scans requires specialized training, which is scarce outside dedicated centers. We sought to investigate the clinical usefulness of computer-generated representations of local grey matter (GM) loss or
Externí odkaz:
https://doaj.org/article/2e2d4a9a78ad479e9615df45306bfd90
Autor:
Lora Minkova, Jessica Peter, Ahmed Abdulkadir, Lena V. Schumacher, Christoph P. Kaller, Christoph Nissen, Stefan Klöppel, Jacob Lahr
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Transcranial magnetic stimulation (TMS) is a well-established tool in probing cortical plasticity in vivo. Changes in corticomotor excitability can be induced using paired associative stimulation (PAS) protocol, in which TMS over the primary motor co
Externí odkaz:
https://doaj.org/article/a0ea8e3200434a88b73c590ca9f8716a
Autor:
Jacob Lahr, Lora Minkova, Sarah J. Tabrizi, Julie C. Stout, Stefan Klöppel, Elisa Scheller, the TrackOn-HD Investigators, A. Coleman, J. Decolongon, M. Fan, T. Koren, C. Jauffret, D. Justo, S. Lehericy, K. Nigaud, R. Valabrègue, A. Schoonderbeek, E. P. ‘t Hart, H. Crawford, S. Gregory, D. Hensman Moss, E. Johnson, J. Read, G. Owen, M. Papoutsi, C. Berna, A. Razi, G. Rees, R. I. Scahill, D. Craufurd, R. Reilmann, N. Weber, J. Stout, I. Labuschagne, M. Orth, G. B. Landwehrmeyer, D. Langbehn, H. Johnson, J. Long, J. Mills
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Huntington’s disease (HD) is a genetically caused neurodegenerative disorder characterized by heterogeneous motor, psychiatric, and cognitive symptoms. Although motor symptoms may be the most prominent presentation, cognitive symptoms such as memor
Externí odkaz:
https://doaj.org/article/c4ae59d737bd4473a864c93be1985ab9
Autor:
Elisa Scheller, Lena V. Schumacher, Jessica Peter, Jacob Lahr, Julius Wehrle, Christoph P. Kaller, Christian Gaser, Stefan Klöppel
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Compensation implies the recruitment of additional neuronal resources to prevent the detrimental effect of age-related neuronal decline on cognition. Recently suggested statistical models comprise behavioral performance, brain activation, and measure
Externí odkaz:
https://doaj.org/article/bc8a16e26239404ea4b527db9ba203ed
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154880 (2016)
Paired associative stimulation (PAS) is a widely used transcranial magnetic stimulation (TMS) paradigm to non-invasively induce synaptic plasticity in the human brain in vivo. Altered PAS-induced plasticity has been demonstrated for several diseases.
Externí odkaz:
https://doaj.org/article/86061d62e1194f1192297d1b37ca9708
Autor:
Elisa Scheller, Irina Mader, Jacob Lahr, Lena V. Schumacher, Stefan Klöppel, Christoph P. Kaller, Jessica Peter
Publikováno v:
Neurobiology of Aging. 56:127-137
The APOE ε4 allele increases the risk for sporadic Alzheimer's disease and modifies brain activation patterns of numerous cognitive domains. We assessed cognitively intact older adults with a letter n-back task to determine if previously observed in
Autor:
Lena Köstering, Michel J. Grothe, Bernhard Heimbach, Christoph Nissen, Claus Normann, Michael Hüll, Christoph P. Kaller, Eliza Lauer, Lora Minkova, Stefan J. Teipel, Jacob Lahr, Jessica Peter, Janine Reis, Stefan Klöppel
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer's disease 53(3), 991-1001 (2016). doi:10.3233/JAD-160273
Journal of Alzheimer's disease 53(3), 991-1001 (2016). doi:10.3233/JAD-160273
Acetylcholine is critically involved in modulating learning and memory function, which both decline in neurodegeneration. It remains unclear to what extent structural and functional changes in the cholinergic system contribute to episodic memory dysf
Autor:
Ad Aertsen, Carsten H. Wolters, Felix Lucka, Lukas D. J. Fiederer, Jacob Lahr, Andreas Schulze-Bonhage, Tonio Ball, Johannes Vorwerk
Publikováno v:
IEEE transactions on bio-medical engineering
Objective: Electric fields (EF) of approx. 0.2 V/m have been shown to be sufficiently strong to both modulate neuronal activity in the cerebral cortex and have measurable effects on cognitive performance. We hypothesized that the EF caused by the ele