Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Jacob L. McCauley"'
Autor:
Gillian E. Jacobsen, Irina Fernández, Maria A. Quintero, Ana M. Santander, Judith Pignac-Kobinger, Oriana M. Damas, Amar R. Deshpande, David H. Kerman, Yuguang Ban, Zhen Gao, Tiago C. Silva, Lily Wang, Ashley H. Beecham, Jacob L. McCauley, Juan F. Burgueño, Maria T. Abreu
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 3, Pp 380-392 (2022)
Background and Aims: Lamina propria phagocytes are key mediators of inflammatory bowel disease (IBD). We aimed to understand the transcriptomic and functional differences in these cells based on location, disease type, inflammation state, and medicat
Externí odkaz:
https://doaj.org/article/a702178d03bb4087813b377a24904480
Autor:
Teresa Fazia, Daria Marzanati, Anna Laura Carotenuto, Ashley Beecham, Athena Hadjixenofontos, Jacob L. McCauley, Valeria Saddi, Marialuisa Piras, Luisa Bernardinelli, Davide Gentilini
Publikováno v:
Current Issues in Molecular Biology, Vol 43, Iss 3, Pp 1778-1793 (2021)
Multiple Sclerosis (MS) is a complex multifactorial autoimmune disease, whose sex- and age-adjusted prevalence in Sardinia (Italy) is among the highest worldwide. To date, 233 loci were associated with MS and almost 20% of risk heritability is attrib
Externí odkaz:
https://doaj.org/article/8a57d49e240f42eaabb0d4badb50bb82
Autor:
Nathan Nakatsuka, Nick Patterson, Nikolaos A. Patsopoulos, Nicolas Altemose, Arti Tandon, Ashley H. Beecham, Jacob L. McCauley, Noriko Isobe, Stephen Hauser, Philip L. De Jager, David A. Hafler, Jorge R. Oksenberg, David Reich
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Epidemiological studies have suggested differences in the rate of multiple sclerosis (MS) in individuals of European ancestry compared to African ancestry, motivating genetic scans to identify variants that could contribute to such patterns.
Externí odkaz:
https://doaj.org/article/bbacc879fe7649be855764f1db11ac9a
Autor:
Andrea Nova, Giulia Nicole Baldrighi, Teresa Fazia, Francesca Graziano, Valeria Saddi, Marialuisa Piras, Ashley Beecham, Jacob L. McCauley, Luisa Bernardinelli
Publikováno v:
Life, Vol 12, Iss 7, p 1101 (2022)
This work aimed at estimating narrow-sense heritability, defined as the proportion of the phenotypic variance explained by the sum of additive genetic effects, via Haseman–Elston regression for a subset of 56 plasma protein levels related to Multip
Externí odkaz:
https://doaj.org/article/57a90e715d2a47139988516b4380f34d
Autor:
Stephen D. Nimer MD, Jennifer Chapman MD, Lisa Reidy PhD, Alvaro Alencar MD, YanYun Wu MD, PhD, Sion Williams PhD, Lazara Pagan MSN, Lauren Gjolaj MBA, Jessica MacIntyre MSN, Melissa Triana MBA, Barbara Vance PhD, David Andrews MD, Yao-Shan Fan MD, PhD, Yi Zhou MD, PhD, Octavio Martinez MD, Monica Garcia-Buitrago MD, Carolyn Cray PhD, Mustafa Tekin MD, Jacob L. McCauley PhD, Philip Ruiz MD, PhD, Paola Pagan MBA, Walter Lamar PhD, Maritza Alencar DNP, Daniel Bilbao PhD, Silvia Prieto MBA, Maritza Polania MBA, Maritza Suarez MD, Melissa Lujardo BSIE, Gloria Campos MSIE, Michele Morris MD, Bhavarth Shukla MD, Alberto Caban-Martinez PhD, DO, Erin Kobetz PhD, Dipen J. Parekh MD, Merce Jorda MD, PhD, MBA
Publikováno v:
Academic Pathology, Vol 7 (2020)
When South Florida became a hot spot for COVID-19 disease in March 2020, we faced an urgent need to develop test capability to detect SARS-CoV-2 infection. We assembled a transdisciplinary team of knowledgeable and dedicated physicians, scientists, t
Externí odkaz:
https://doaj.org/article/dd62565c821e4b03a7196cfab74626fb
Autor:
Andrea Nova, Teresa Fazia, Ashley Beecham, Valeria Saddi, Marialuisa Piras, Jacob L. McCauley, Carlo Berzuini, Luisa Bernardinelli
Publikováno v:
Life, Vol 12, Iss 2, p 151 (2022)
Here we investigate protein levels in 69 multiple sclerosis (MS) cases and 143 healthy controls (HC) from twenty Sardinian families to search for promising biomarkers in plasma. Using antibody suspension bead array technology, the plasma levels of 56
Externí odkaz:
https://doaj.org/article/568a816ec3f04994898620f9464c39e0
Autor:
Teresa Fazia, Andrea Nova, Davide Gentilini, Ashley Beecham, Marialuisa Piras, Valeria Saddi, Anna Ticca, Pierpaolo Bitti, Jacob L. McCauley, Carlo Berzuini, Luisa Bernardinelli
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Multiple Sclerosis (MS) exhibits considerable heterogeneity in phenotypic expression, course, prognosis and response to therapy. This suggests this disease involves multiple, as yet poorly understood, causal mechanisms. In this work we assessed the p
Externí odkaz:
https://doaj.org/article/379b37ac786b486abea016b9bfe44c10
Autor:
Michael L. Cuccaro, Clara P. Manrique, Maria A. Quintero, Ricardo Martinez, Jacob L. McCauley
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
This study examined reasons for participation in a genetic study of risk for multiple sclerosis (MS). Our sample consisted of 101 patients diagnosed with MS who were approached about enrolling in the Multiple Sclerosis Genetic Susceptibility Study. P
Externí odkaz:
https://doaj.org/article/b910530941074b72a93fd786720802b6
Autor:
Briseida E. Feliciano-Astacio, Katrina Celis, Jairo Ramos, Farid Rajabli, Larry Deon Adams, Alejandra Rodriguez, Vanessa Rodriguez, Parker L. Bussies, Carolina Sierra, Patricia Manrique, Pedro R. Mena, Antonella Grana, Michael Prough, Kara L. Hamilton-Nelson, Nereida Feliciano, Angel Chinea, Heriberto Acosta, Jacob L. McCauley, Jeffery M. Vance, Gary W. Beecham, Margaret A. Pericak-Vance, Michael L. Cuccaro
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
IntroductionPuerto Ricans, the second largest Latino group in the continental US, are underrepresented in genomic studies of Alzheimer disease (AD). To increase representation of this group in genomic studies of AD, we developed a multisource ascerta
Externí odkaz:
https://doaj.org/article/6b3c39d31d3f403a93ea149ba07498e2
Autor:
Ashley H. Beecham, Jacob L. McCauley
Publikováno v:
Genes, Vol 10, Iss 11, p 903 (2019)
While approximately 200 autosomal genetic associations outside of the major histocompatibility complex (MHC) have been identified for multiple sclerosis (MS) risk in European populations, causal variants identified at the majority of these associated
Externí odkaz:
https://doaj.org/article/05926cb2d0894200b3aebeba9aa6f4c5