Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jacob Kihlström"'
Autor:
Bertil Samuelsson, Jenny K. Ekegren, Mats Larhed, Linda Axelsson, Hans Wallberg, Jacob Kihlström, Anders Hallberg, Johan Wannberg, Torsten Unge, A. K. Mahalingam
Publikováno v:
Journal of Medicinal Chemistry. 53:607-615
By a small modification in the core structure of the previously reported series of HIV-1 protease inhibitors that encompasses a tertiary alcohol as part of the transition-state mimicking scaffold, up to 56 times more potent compounds were obtained ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767caf1d50231e6a2eba407b205783f0
https://doi.org/10.1021/jm901165g
https://doi.org/10.1021/jm901165g
Autor:
Ylva, Gravenfors, Jenny, Viklund, Jan, Blid, Tobias, Ginman, Sofia, Karlström, Jacob, Kihlström, Karin, Kolmodin, Johan, Lindström, Stefan, von Berg, Fredrik, von Kieseritzky, Krisztian, Bogar, Can, Slivo, Britt-Marie, Swahn, Lise-Lotte, Olsson, Patrik, Johansson, Susanna, Eketjäll, Johanna, Fälting, Fredrik, Jeppsson, Kia, Strömberg, Juliette, Janson, Fredrik, Rahm
Publikováno v:
Journal of medicinal chemistry. 55(21)
Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer’s disease. Synthetic methods, crystal structures, and structure–activity relationships for target activity, permeability, and hERG activity are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e0ec2c24a4566dacbf31db9c6264bc
https://pubmed.ncbi.nlm.nih.gov/23017051
https://pubmed.ncbi.nlm.nih.gov/23017051
Autor:
Britt-Marie Swahn, Niklas Plobeck, Karin Kolmodin, J. Lindstrom, Fernando Sehgelmeble, Didier Rotticci, Stefan von Berg, Biljana Georgievska, Johanna Fälting, Susanne Gustavsson, Stefan Berg, Jan A.M. Neelissen, Jörg Holenz, M. Sundstrom, Lise-Lotte Olsson, Margareta Ek, Jacob Kihlström
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(5)
The evaluation of a series of bicyclic aminoimidazoles as potent BACE-1 inhibitors is described. The crystal structures of compounds 14 and 23 in complex with BACE-1 reveal hydrogen bond interactions with the protein important for achieving potent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b192f43d03cfcf44c31a9e0efca42b87
https://pubmed.ncbi.nlm.nih.gov/22325942
https://pubmed.ncbi.nlm.nih.gov/22325942
Autor:
Jacob Kihlström, Johan Lindström, Fredrik Jeppsson, Johanna Fälting, Can Slivo, Tobias Ginman, Susanna Eketjäll, Jenny Viklund, Fredrik Rahm, Patrik Johansson, Jan Blid, Britt-Marie Swahn, Juliette Janson, Karin Kolmodin, Ylva Gravenfors, Krisztián Bogár, Stefan von Berg, Lise-Lotte Olsson, Kia Strömberg, Fredrik von Kieseritzky, Sofia Karlström
Publikováno v:
Journal of Medicinal Chemistry. 55:10316-10316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e1081d06fc452e5b5f2bc8f7c0e42dc
https://doi.org/10.1021/jm301629c
https://doi.org/10.1021/jm301629c
Autor:
A.K. Mahalingam, Linda Axelsson, Jenny K. Ekegren, Johan Wannberg, Jacob Kihlström, Torsten Unge, Hans Wallberg, Bertil Samuelsson, Mats Larhed, Anders Hallberg
Publikováno v:
Journal of Medicinal Chemistry; Jan2010, Vol. 53 Issue 2, p607-615, 9p