Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jacob K. Hilton"'
Autor:
Minjoo Kim, Nicholas J. Sisco, Jacob K. Hilton, Camila M. Montano, Manuel A. Castro, Brian R. Cherry, Marcia Levitus, Wade D. Van Horn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The TRPV1 ion channel is a heat-sensing receptor that is also activated by vanilloid compounds, but the molecular underpinnings of thermosensing have remained elusive. Here authors use in solution NMR on the isolated human TRPV1 S1-S4 domain and show
Externí odkaz:
https://doaj.org/article/031b403abc3941b8bfde584589cc3cd7
Autor:
Xavier Leray, Jacob K Hilton, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell
Publikováno v:
eLife, Vol 11 (2022)
The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H+ ATPase, but other pathways for ion movement are required to dissipate the
Externí odkaz:
https://doaj.org/article/ba99f83a0c944e9299218d4891a98871
Autor:
William J. Rice, Joseph A. Mindell, Jacob K. Hilton, David B. Sauer, Jinmei Song, Nathan K. Karpowich, Bing Wang, Da-Neng Wang
Publikováno v:
Nature
Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition to this essential role in energy metabolism, the tricarboxylate anion also acts as both a precursor and a regulator of fatty acid synthesis1-3. Thus, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94d427bab3df3b9ca64667d24199fdc
https://doi.org/10.1038/s41586-021-03230-x
https://doi.org/10.1038/s41586-021-03230-x
Autor:
Jacob K Hilton, Xavier Leray, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80647cf15828fb6fb8ac6eb976d6a4d9
https://doi.org/10.7554/elife.74136.sa2
https://doi.org/10.7554/elife.74136.sa2
Autor:
Jacob K. Hilton, Joseph A. Mindell
Publikováno v:
Biophysical Journal. 122:397a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::347c7b922f0460d2ca5e224cac51cbfc
https://doi.org/10.1016/j.bpj.2022.11.2167
https://doi.org/10.1016/j.bpj.2022.11.2167
Publikováno v:
Biophysical Journal. 122:397a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9dcd44e1847601f1a507a7f3ce39aac
https://doi.org/10.1016/j.bpj.2022.11.2166
https://doi.org/10.1016/j.bpj.2022.11.2166
Autor:
Jacob K. Hilton, Xavier Leray, Kamsiyochukwu Nwangwu, Alissa J. Becerril, Gabriel Fitzgerald, Anowarul Amin, Mary Weston, Joseph A. Mindell
Publikováno v:
Biophysical Journal. 121:26a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9833949d01daaf68d7ae867bbdd8411
https://doi.org/10.1016/j.bpj.2021.11.2577
https://doi.org/10.1016/j.bpj.2021.11.2577
Autor:
Colleen E. Heffner, Saifur Rahman, Yuanqiang Wang, Gregorio Fernández-Ballester, Antonio Ferrer-Montiel, V. Blair Journigan, Nicholas Bachtel, Xiang-Qun Xie, Asia Fernández-Carvajal, Wade D. Van Horn, A.R.M. Ruhul Amin, Taufiq Rahman, Sara González-Rodríguez, Siyi Wang, Jacob K. Hilton, Zhiwei Feng
Publikováno v:
ACS Chem Neurosci
Structure–activity relationship studies of a reported menthol-based transient receptor potential cation channel subfamily M member 8 channel (TRPM8) antagonist, guided by computational simulations and structure-based design, uncovers a novel series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea875ba50b9e62a57dea7d3a6e2d94e
https://pubmed.ncbi.nlm.nih.gov/31850745
https://pubmed.ncbi.nlm.nih.gov/31850745
Publikováno v:
Journal of Biological Chemistry. 293:9423-9434
Transient receptor potential melastatin 8 (TRPM8) is a cold-sensitive ion channel with diverse physiological roles. TRPM8 activity is modulated by many mechanisms, including an interaction with the small membrane protein phosphoinositide-interacting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60242e4b96394f26bc22e60f22c89f18
https://doi.org/10.1074/jbc.ra118.003563
https://doi.org/10.1074/jbc.ra118.003563
Publikováno v:
Biophysical Journal. 118:413a-414a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb49bd5f4fc0d029a21a8e8dff355b8a
https://doi.org/10.1016/j.bpj.2019.11.2338
https://doi.org/10.1016/j.bpj.2019.11.2338