Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jacob K. Grohman"'
Autor:
Yidan Qin, Seung K. Park, Jennifer L. Stamos, Jacob K. Grohman, Jun Yao, Georg Mohr, Sean Yoon-Seo Kang, Alan M. Lambowitz
Publikováno v:
Journal of molecular biology. 430(17)
The thermostable Geobacillus stearothermophilus GsI-IIC intron is among the few bacterial group II introns found to proliferate to high copy number in its host genome. Here, we developed a bacterial genetic assay for retrohoming and biochemical assay
Autor:
Kevin M. Weeks, Robert J. Gorelick, Sumith Kottegoda, Jacob K. Grohman, Nancy L. Allbritton, Alan Rein
Publikováno v:
Journal of Virology. 88:6061-6068
Retroviral virions initially assemble in an immature form that differs from that of the mature infectious particle. The RNA genomes in both immature and infectious particles are dimers, and interactions between the RNA dimer and the viral Gag protein
Autor:
Robert J. Gorelick, Kevin M. Weeks, Brent M. Znosko, Jason D. Lieb, Jacob K. Grohman, Brian D. Bower, Colin R. Lickwar
Publikováno v:
Science. 340:190-195
RNA chaperones are ubiquitous, heterogeneous proteins essential for RNA structural biogenesis and function. We investigated the mechanism of chaperone-mediated RNA folding by following the time-resolved dimerization of the packaging domain of a retro
Autor:
Pilar Tijerina, Hari Bhaskaran, and Alan M. Lambowitz, Jacob K. Grohman, Mark Del Campo, Rick Russell
Publikováno v:
Biochemistry. 46:3013-3022
The DEAD-box protein CYT-19 functions in the folding of several group I introns in vivo and a diverse set of group I and group II RNAs in vitro. Recent work using the Tetrahymena group I ribozyme demonstrated that CYT-19 possesses a second RNA-bindin
Publikováno v:
Journal of the American Chemical Society. 133(50)
Higher-order structure influences critical functions in nearly all noncoding and coding RNAs. Most single-nucleotide resolution RNA structure determination technologies cannot be used to analyze RNA from scarce biological samples, like viral genomes.