Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jacob K. Flynn"'
Autor:
Alexandra M. Ortiz, Jennifer Simpson, Charlotte A. Langner, Phillip J. Baker, Cynthia Aguilar, Kelsie Brooks, Jacob K. Flynn, Carol L. Vinton, Andrew R. Rahmberg, Heather D. Hickman, Jason M. Brenchley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Defective gastrointestinal barrier function and, in turn, microbial translocation have been identified as significant contributors to persistent inflammation in antiretroviral (ARV)-treated people living with HIV. Metabolic supplementation o
Externí odkaz:
https://doaj.org/article/cf5b60b70f2f47a591ba68af57beaeed
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT The bacterial component of the gastrointestinal tract microbiome is comprised of hundreds of species, the majority of which live in symbiosis with the host. The bacterial microbiome is influenced by host diet and disease history, and host ge
Externí odkaz:
https://doaj.org/article/708cd3b03ed74c28b44997069b05d793
Autor:
Alexandra M. Ortiz, Phillip J. Baker, Charlotte A. Langner, Jennifer Simpson, Apollo Stacy, Jacob K. Flynn, Carly E. Starke, Carol L. Vinton, Christine M. Fennessey, Yasmine Belkaid, Brandon F. Keele, Jason M. Brenchley
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112020- (2023)
Summary: Variations in the composition of the intestinal bacterial microbiome correlate with acquisition of some sexually transmitted pathogens. To experimentally assess the contribution of intestinal dysbiosis to rectal lentiviral acquisition, we in
Externí odkaz:
https://doaj.org/article/7081ddf554cf4942b21ea596c9eb27a3
Autor:
Carol L. Vinton, Carly E. Starke, Alexandra M. Ortiz, Stephen H. Lai, Jacob K. Flynn, Ornella Sortino, Kenneth Knox, Irini Sereti, Jason Brenchley
Publikováno v:
Pathogens and Immunity, Vol 5, Iss 1, Pp 68-88 (2020)
Abstract Background: Microbial translocation occurs after damage to the structural and/or immunological barrier of the gastrointestinal (GI) tract into circulation. Microbial components that translocate from the lumen of the GI tract directly stimula
Externí odkaz:
https://doaj.org/article/d13267769b144025882a00af089fc6cc
Autor:
Charlotte A. Langner, Alexandra M. Ortiz, Jacob K. Flynn, Heather Kendall, Laurel A. Lagenaur, Jason M. Brenchley
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT The vaginal microbiome composition in humans is categorized based upon the degree to which one of four species of Lactobacillus is dominant (Lactobacillus crispatus, community state type I [CST I], Lactobacillus gasseri, CST II, Lactobacillu
Externí odkaz:
https://doaj.org/article/c233818a83a24dceb9fa3787b6f8913c
Autor:
Joseph C. Mudd, Stephen Lai, Sanjana Shah, Andrew Rahmberg, Jacob K. Flynn, Carly E. Starke, Molly R. Perkins, Amy Ransier, Sam Darko, Daniel C. Douek, Vanessa M. Hirsch, Mark Cameron, Jason M. Brenchley
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
African green monkeys (AGMs) are natural hosts of SIV that postthymically downregulate CD4 to maintain a large population of CD4–CD8aa+ virus-resistant cells with Th functionality, which can result in AGMs becoming apparently cured of SIVagm infect
Externí odkaz:
https://doaj.org/article/275efb05e70845b9940e8ac35717c5a1
Autor:
Erik P. Karmele, Steven E. Bosinger, Jacob K. Flynn, Nihal Altan-Bonnet, Charlotte A. Langner, Luxin Pei, Thomas B. Nutman, Rachele M Bochart, Marianita Santiana, Margery G. Smelkinson, Brian L. Kelsall, Alexandra M. Ortiz, Phillip J. Baker, Edlawit G Gorfu, Jason M. Brenchley
Publikováno v:
Mucosal immunology
Microbial translocation contributes to persistent inflammation in both treated and untreated HIV infection. Although translocation is due in part to a disintegration of the intestinal epithelial barrier, there is a bias towards the translocation of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab65a1de8f1fdc383d836cfa4f3e89b
http://europepmc.org/articles/PMC8225551
http://europepmc.org/articles/PMC8225551
Autor:
Irini Sereti, Kenneth S. Knox, Jacob K. Flynn, Jason M. Brenchley, Stephen H. Lai, Alexandra M. Ortiz, Ornella Sortino, Carol L. Vinton, Carly E. Starke
Publikováno v:
Pathogens and Immunity, Vol 5, Iss 1, Pp 68-88 (2020)
Pathogens and Immunity
Pathogens and Immunity
Background: Microbial translocation occurs after damage to the structural and/or immunological barrier of the gastrointestinal (GI) tract into circulation. Microbial components that translocate from the lumen of the GI tract directly stimulate the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d670d1cc7a45caa4024c24364ab0a37
https://paijournal.com/index.php/paijournal/article/view/363
https://paijournal.com/index.php/paijournal/article/view/363
Autor:
Alexandra M, Ortiz, Jennifer, Simpson, Charlotte A, Langner, Phillip J, Baker, Cynthia, Aguilar, Kelsie, Brooks, Jacob K, Flynn, Carol L, Vinton, Andrew R, Rahmberg, Heather D, Hickman, Jason M, Brenchley
Publikováno v:
Scientific reports. 12(1)
Defective gastrointestinal barrier function and, in turn, microbial translocation have been identified as significant contributors to persistent inflammation in antiretroviral (ARV)-treated people living with HIV. Metabolic supplementation of short-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84aa1c9024d4239d4e761290e213093c
https://pubmed.ncbi.nlm.nih.gov/35523797
https://pubmed.ncbi.nlm.nih.gov/35523797
Autor:
Rachel M Presti, Eunice Yeh, Brett Williams, Alan Landay, Jeffrey M Jacobson, Cara Wilson, Carl J Fichtenbaum, Netanya S Utay, Michael P Dube, Karin L Klingman, Jacob D Estes, Jacob K Flynn, Amanda Loftin, Jason M Brenchley, Adriana Andrade, Douglas W Kitch, Edgar T Overton
Publikováno v:
Open Forum Infectious Diseases
Background A5350, a phase II, randomized, double-blind study, evaluated the safety and tolerability of the probiotic Visbiome Extra Strength (ES) over 24 weeks and measured effects on inflammation and intestinal barrier function. Methods The primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da3e6dbb7dfc05e5e99b8d143edfd45
https://pubmed.ncbi.nlm.nih.gov/34888397
https://pubmed.ncbi.nlm.nih.gov/34888397