Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jacob Jeppesen"'
Autor:
Maximilian Kleinert, Benjamin L. Parker, Rima Chaudhuri, Daniel J. Fazakerley, Annette Serup, Kristen C. Thomas, James R. Krycer, Lykke Sylow, Andreas M. Fritzen, Nolan J. Hoffman, Jacob Jeppesen, Peter Schjerling, Markus A. Ruegg, Bente Kiens, David E. James, Erik A. Richter
Publikováno v:
Molecular Metabolism, Vol 5, Iss 8, Pp 646-655 (2016)
Objective: We have recently shown that acute inhibition of both mTOR complexes (mTORC1 and mTORC2) increases whole-body lipid utilization, while mTORC1 inhibition had no effect. Therefore, we tested the hypothesis that mTORC2 regulates lipid metaboli
Externí odkaz:
https://doaj.org/article/db4cfad4b24e438e88473b12dcfae495
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 6, Pp 1504-1512 (2010)
The primary aim of the present study was to investigate in which cellular compartments fatty acid translocase CD36 (FAT/CD36) is localized. Intact and fully functional skeletal muscle mitochondria were isolated from lean and obese female Zucker rat
Externí odkaz:
https://doaj.org/article/ac11668d3035471c830e629c4c03fcbb
Autor:
Christian Frøsig, Thomas E Jensen, Jacob Jeppesen, Christian Pehmøller, Jonas T Treebak, Stine J Maarbjerg, Jonas M Kristensen, Lykke Sylow, Thomas J Alsted, Peter Schjerling, Bente Kiens, Jørgen F P Wojtaszewski, Erik A Richter
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62338 (2013)
The 5'-AMP-activated protein kinase (AMPK) is considered "a metabolic master-switch" in skeletal muscle reducing ATP- consuming processes whilst stimulating ATP regeneration. Within recent years, AMPK has also been proposed as a potential target to a
Externí odkaz:
https://doaj.org/article/dc98e45ee71b43d38484f0835f31be3d
Autor:
Jacob Jeppesen, Andreas B Jordy, Kim A Sjøberg, Joachim Füllekrug, Andreas Stahl, Lars Nybo, Bente Kiens
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29391 (2012)
FATP1 and FATP4 appear to be important for the cellular uptake and handling of long chain fatty acids (LCFA). These findings were obtained from loss- or gain of function models. However, reports on FATP1 and FATP4 in human skeletal muscle are limited
Externí odkaz:
https://doaj.org/article/3d360945d94d48e69993b8bad202efed
Autor:
Jørgen F. P. Wojtaszewski, Jacob Jeppesen, Andreas M. Fritzen, Henrik Hall Deleuran, Louise D. Høeg, Erik A. Richter, Bente Kiens, Kim A. Sjøberg, Anne-Marie Lundsgaard
Publikováno v:
The FASEB Journal. 33:5510-5519
The nicotinamide adenine dinucleotide-dependent deacetylase, sirtuin (SIRT)1, in skeletal muscle is reduced in insulin-resistant states. However, whether this is an initial mechanism responsible for mediating insulin resistance in human skeletal musc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839ee006a5f1447a0073aca1c062fcd9
https://doi.org/10.1096/fj.201801950r
https://doi.org/10.1096/fj.201801950r
Autor:
Ida Marchen Egerod Israelsen, Anne-Marie Lundsgaard, Jacob Jeppesen, Andreas M. Fritzen, Maximilian Kleinert, Bente Kiens, Trine S. Nicolaisen, Joan Domingo-Espín, Christian S. Carl, Rasmus Kjøbsted, Jørgen F. P. Wojtaszewski, Jens O. Lagerstedt
Publikováno v:
Molecular Metabolism
Mol. Metab. 35:100949 (2020)
Molecular Metabolism, Vol 35, Iss, Pp-(2020)
Fritzen, A M, Domingo-Espín, J, Lundsgaard, A, Kleinert, M, Israelsen, I, Carl, C S, Nicolaisen, T S, Kjøbsted, R, Jeppesen, J F, Wojtaszewski, J, Lagerstedt, J O & Kiens, B 2020, ' ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα 2 ', Molecular Metabolism, vol. 35, 100949 . https://doi.org/10.1016/j.molmet.2020.01.013
Mol. Metab. 35:100949 (2020)
Molecular Metabolism, Vol 35, Iss, Pp-(2020)
Fritzen, A M, Domingo-Espín, J, Lundsgaard, A, Kleinert, M, Israelsen, I, Carl, C S, Nicolaisen, T S, Kjøbsted, R, Jeppesen, J F, Wojtaszewski, J, Lagerstedt, J O & Kiens, B 2020, ' ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα 2 ', Molecular Metabolism, vol. 35, 100949 . https://doi.org/10.1016/j.molmet.2020.01.013
Objective Acute administration of the main protein component of high-density lipoprotein, apolipoprotein A-I (ApoA-1), improves glucose uptake in skeletal muscle. The molecular mechanisms mediating this are not known, but in muscle cell cultures, Apo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54300bf7484e007d7d54805c1adbb259
http://europepmc.org/articles/PMC7082546
http://europepmc.org/articles/PMC7082546
Autor:
Per Nørgaard, Jing Su, Jane Boesen Frantzen, Zhiru Yang, Anne Bugge, Chih-Chuan Chang, Linu M. John, Anna Secher, Zhenhua He, Haisun Zhu, Tao Huang, Wei Yang, Kristian Tage Hansen, Xiaoai Wu, Xiang Gao, Sarah J Paulsen, Sebastian Beck Jørgensen, Jacob Jeppesen, Zhe Sun, Linda Yang, Haibin Chen, Bing Shan, Xun Li, Karin Hultman, Jishu Wang, Søren Berg Padkjær, Dennis Madsen
Publikováno v:
Nature Medicine. 23:1158-1166
Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown. Here we show that GD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df7309da29b5ef10acefc642a3c77d83
https://doi.org/10.1038/nm.4394
https://doi.org/10.1038/nm.4394
Autor:
Lene Secher Myrmel, Anne-Marie Lundsgaard, Andreas Børsting Jordy, Jørgen F. P. Wojtaszewski, Lise Madsen, Henriette Pilegaard, Louise D. Høeg, Annette K. Serup, Erik A. Richter, Bente Kiens, Kim A. Sjøberg, Andreas M. Fritzen, Jacob Jeppesen
Publikováno v:
Diabetes. 66:2583-2595
To understand the mechanisms in lipid-induced insulin resistance, a more physiological approach is to enhance fatty acid (FA) availability through the diet. Nine healthy men ingested two hypercaloric diets (in 75% excess of habitual caloric intake) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074671d8cc15436bfa94ba23254a0630
https://doi.org/10.2337/db17-0046
https://doi.org/10.2337/db17-0046
Autor:
Anne-Marie Lundsgaard, Christopher G. Proud, Peter Schjerling, Jacob Jeppesen, Thomas E. Jensen, Christian Frøsig, Annette K. Serup, Erik A. Richter, Bente Kiens, Andreas M. Fritzen
Publikováno v:
Cellular Signalling. 28:663-674
During induction of the autophagosomal degradation process, LC3-I is lipidated to LC3-II and associates to the cargo isolation membrane allowing for autophagosome formation. Lipidation of LC3 results in an increased LC3-II/LC3-I ratio, and this ratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf8a419cfdf45c3f7fee96fdef70030
https://doi.org/10.1016/j.cellsig.2016.03.005
https://doi.org/10.1016/j.cellsig.2016.03.005
Autor:
Jonas M. Kristensen, Anne-Marie Lundsgaard, S. Hansen, Jacob Jeppesen, Nicoline R. Andersen, Jørgen F. P. Wojtaszewski, Louise D. Høeg, Sten Madsbad, Lisbeth Nilas, Pernille Fog Svendsen, Bente Kiens
Publikováno v:
The Journal of clinical endocrinology and metabolism. 104(5)
Context Skeletal muscle molecular mechanisms underlying insulin resistance in women with polycystic ovary syndrome (PCOS) are poorly understood. Objective To provide insight into mechanisms regulating skeletal muscle insulin resistance in women who a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cc1a6636b1207f94bcc7ee81bac204
https://pubmed.ncbi.nlm.nih.gov/30544235
https://pubmed.ncbi.nlm.nih.gov/30544235