Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Jacob Jelsing"'
Autor:
Mathias B. Møllerhøj, Sanne S. Veidal, Kirstine Tølbøl Thrane, Denise Oró, Agnete Overgaard, Casper Gravesen Salinas, Martin Rønn Madsen, Larissa Pfisterer, Mogens Vyberg, Eric Simon, Andre Broermann, Niels Vrang, Jacob Jelsing, Michael Feigh, Henrik H. Hansen
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 5, Pp 1167-1186 (2022)
Abstract Non‐alcoholic steatohepatitis (NASH) has emerged as a major challenge for public health because of high global prevalence and lack of evidence‐based therapies. Most animal models of NASH lack sufficient validation regarding disease progr
Externí odkaz:
https://doaj.org/article/5fe3d3005960450b826f54e82c75529a
Autor:
Flora Alexopoulou, Esben Matzen Bech, Søren Ljungberg Pedersen, Ditte Dencker Thorbek, Ulrike Leurs, Lise Christine Biehl Rudkjær, Keld Fosgerau, Henrik H. Hansen, Niels Vrang, Jacob Jelsing, Lisbeth Elster
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Prolactin-releasing peptide (PrRP) is an endogenous neuropeptide involved in appetite regulation and energy homeostasis. PrRP binds with high affinity to G-protein coupled receptor 10 (GPR10) and with lesser activity towards the neuropeptide
Externí odkaz:
https://doaj.org/article/8e0d5489416b4764ae5a32eabd49a97e
Autor:
Henrik H. Hansen, Rikke V. Grønlund, Tamara Baader-Pagler, Peter Haebel, Harald Tammen, Leif Kongskov Larsen, Jacob Jelsing, Niels Vrang, Thomas Klein
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Dipeptidyl peptidase IV (DPP-IV) inhibitors improve glycemic control by prolonging the action of glucagon-like peptide-1 (GLP-1). In contrast to GLP-1 analogues, DPP-IV inhibitors are weight-neutral. DPP-IV cleavage of PYY and NPY gives rise
Externí odkaz:
https://doaj.org/article/97a3ac05b965484c814efcbeef1dbf0b
Autor:
Urmas Roostalu, Louise Thisted, Jacob Lercke Skytte, Casper Gravesen Salinas, Philip Juhl Pedersen, Jacob Hecksher-Sørensen, Bidda Rolin, Henrik H. Hansen, James G. MacKrell, Robert M. Christie, Niels Vrang, Jacob Jelsing, Nora Elisabeth Zois
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Angiotensin converting enzyme inhibitors, among them captopril, improve survival following myocardial infarction (MI). The mechanisms of captopril action remain inadequately understood due to its diverse effects on multiple signalling pathwa
Externí odkaz:
https://doaj.org/article/5eb67c5b398c476eaf57ac9ff978429a
Autor:
Christoffer A. Hagemann, Christian Legart, Mathias B. Møllerhøj, Martin R. Madsen, Henrik H. Hansen, Merete J. Kønig, Frederik Helgstrand, Flemming P. Hjørne, Anders Toxværd, Jill L. Langhoff, Urd L. Kielgast, Lise L. Gluud, Helene Ægidius, Kristoffer T. G. Rigbolt, Tina Vilsbøll, Jacob Jelsing, Filip K. Knop
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Non-invasive biomarkers of non-alcoholic fatty liver disease (NAFLD) supporting diagnosis and monitoring disease progression are urgently needed. The present study aimed to establish a bioinformatics pipeline capable of defining and validating NAFLD
Externí odkaz:
https://doaj.org/article/cd560326640944a2ab5191490a7323d7
Autor:
Henrik H. Hansen, Helene M. Ægidius, Denise Oró, Simon S. Evers, Sara Heebøll, Peter Lykke Eriksen, Karen Louise Thomsen, Anja Bengtsson, Sanne S. Veidal, Michel Feigh, Malte P. Suppli, Filip K. Knop, Henning Grønbæk, Diego Miranda, James L. Trevaskis, Niels Vrang, Jacob Jelsing, Kristoffer T. G. Rigbolt
Publikováno v:
BMC Gastroenterology, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Animal models of non-alcoholic steatohepatitis (NASH) are important tools in preclinical research and drug discovery. Gubra-Amylin NASH (GAN) diet-induced obese (DIO) mice represent a model of fibrosing NASH. The present study dir
Externí odkaz:
https://doaj.org/article/738511df0fdc4d36be87fd7875e0fda9
Autor:
Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Christina Christoffersen, Michael Feigh, Niels Vrang, Jonathan David Roth, Mary Erickson, Luciano Adorini, Jacob Jelsing
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Compounds in clinical development for nonalcoholic steatohepatitis (NASH) improve liver histopathology in diet-induced obese mouse models of biopsy-confirmed NASH. Since the biopsy section used for histopathological evaluation rep
Externí odkaz:
https://doaj.org/article/e44142f92aa546f5bc09dfe64650bb25
Autor:
Mette Simone Aae Madsen, Jacob Bak Holm, Albert Pallejà, Pernille Wismann, Katrine Fabricius, Kristoffer Rigbolt, Martin Mikkelsen, Morten Sommer, Jacob Jelsing, Henrik Bjørn Nielsen, Niels Vrang, Henrik H. Hansen
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Enteroendocrine L-cell derived peptide hormones, notably glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2), have become important targets in the treatment of type 2 diabetes, obesity and intestinal diseases. As gut microbia
Externí odkaz:
https://doaj.org/article/7cc76709e4214ac29b3c51f8c12f05a0
Autor:
Frederikke E. Sembach, Helene M. Ægidius, Lisbeth N. Fink, Thomas Secher, Annemarie Aarup, Jacob Jelsing, Niels Vrang, Bo Feldt-Rasmussen, Kristoffer T. G. Rigbolt, Jens C. Nielsen, Mette V. Østergaard
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
The current understanding of molecular mechanisms driving diabetic kidney disease (DKD) is limited, partly due to the complex structure of the kidney. To identify genes and signalling pathways involved in the progression of DKD, we compared kidney co
Externí odkaz:
https://doaj.org/article/81d68d895ca048628b90770834252305
Autor:
Henrik H. Hansen, Johanna Perens, Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Pernille Barkholt, Ditte Dencker Thorbek, Kristoffer T.G. Rigbolt, Niels Vrang, Jacob Jelsing, Jacob Hecksher-Sørensen
Publikováno v:
Molecular Metabolism, Vol 47, Iss , Pp 101171- (2021)
Objective: The development of effective anti-obesity therapeutics relies heavily on the ability to target specific brain homeostatic and hedonic mechanisms controlling body weight. To obtain further insight into neurocircuits recruited by anti-obesit
Externí odkaz:
https://doaj.org/article/bd964deac5714ad4a7d015ebc7bd52eb