Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jacob J. Swidorski"'
Autor:
Jacob J. Swidorski, Brett R. Beno, Chunjian Liu, David S. Yoon, Kaushik Ghosh, Harinath Sale, Devang Shah, Kriti Acharya, Joseph Yanchunas, Priyanka Haldar, Narasimharaju Kalidindi, Jinal K. Shukla, Matthew Argentieri, Bruce A. Ellsworth, Dong Cheng, Alicia Regueiro-Ren
Galectin proteins have been targets of interest in numerous therapeutic areas for some time. Galectin-3 has been identified as a target of particular interest because of its unique structural characteristics and physiological profile. Recent literatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06004e2a3b8e97e9e0861334cbf1b9b1
https://doi.org/10.21203/rs.3.rs-2757730/v1
https://doi.org/10.21203/rs.3.rs-2757730/v1
Autor:
Alicia Regueiro-Ren, Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob J. Swidorski, Zheng Liu, Brian L. Venables, Ny Sin, Richard A. Hartz, Tricia Protack, Zeyu Lin, Sharon Zhang, Zhufang Li, Dauh-Rurng Wu, Peng Li, James Kempson, Xiaoping Hou, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Hyunsoo Park, Amy Sarjeant, Yulia Benitex, Sandhya Rahematpura, Dawn Parker, Thomas Phillips, Roy Haskell, Susan Jenkins, Kenneth S. Santone, Mark Cockett, Umesh Hanumegowda, Ira Dicker, Nicholas A. Meanwell, Mark Krystal
Publikováno v:
Journal of medicinal chemistry. 65(18)
GSK3640254 is an HIV-1 maturation inhibitor (MI) that exhibits significantly improved antiviral activity toward a range of clinically relevant polymorphic variants with reduced sensitivity toward the second-generation MI GSK3532795 (BMS-955176). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd326815d3682de3b91571d910517928
https://pubmed.ncbi.nlm.nih.gov/36044257
https://pubmed.ncbi.nlm.nih.gov/36044257
Autor:
Alicia Regueiro-Ren, Jacob J. Swidorski, Zheng Liu, Yan Chen, Ny Sin, Sing-Yuen Sit, Jie Chen, Brian L. Venables, Juliang Zhu, Beata Nowicka-Sans, Tricia Protack, Zeyu Lin, Brian Terry, Himadri Samanta, Sharon Zhang, Zhufang Li, John Easter, Brett R. Beno, Vinod Arora, Xiaohua S. Huang, Sandhya Rahematpura, Dawn D. Parker, Roy Haskell, Kenneth S. Santone, Mark I. Cockett, Mark Krystal, Nicholas A. Meanwell, Susan Jenkins, Umesh Hanumegowda, Ira B. Dicker
Publikováno v:
Journal of Medicinal Chemistry. 61:7289-7313
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c3666e9905493812ef4d0ec28c2e176
https://doi.org/10.1021/acs.jmedchem.8b00854
https://doi.org/10.1021/acs.jmedchem.8b00854
Autor:
Alicia, Regueiro-Ren, Jacob J, Swidorski, Zheng, Liu, Yan, Chen, Ny, Sin, Sing-Yuen, Sit, Jie, Chen, Brian L, Venables, Juliang, Zhu, Beata, Nowicka-Sans, Tricia, Protack, Zeyu, Lin, Brian, Terry, Himadri, Samanta, Sharon, Zhang, Zhufang, Li, John, Easter, Brett R, Beno, Vinod, Arora, Xiaohua S, Huang, Sandhya, Rahematpura, Dawn D, Parker, Roy, Haskell, Kenneth S, Santone, Mark I, Cockett, Mark, Krystal, Nicholas A, Meanwell, Susan, Jenkins, Umesh, Hanumegowda, Ira B, Dicker
Publikováno v:
Journal of medicinal chemistry. 61(16)
GSK3532795, formerly known as BMS-955176 (1), is a potent, orally active, second-generation HIV-1 maturation inhibitor (MI) that advanced through phase IIb clinical trials. The careful design, selection, and evaluation of substituents appended to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec69348335bb02844efe70a17d779260
https://pubmed.ncbi.nlm.nih.gov/30067361
https://pubmed.ncbi.nlm.nih.gov/30067361
Autor:
Jacob J. Swidorski, Jiashi Wang, R. Lizeth P. Munoz, Michael J. McLaughlin, Richard P. Hsung, Xuejun Zhang
Publikováno v:
Synthesis. 2007:749-753
Electrophilic substitution protocols useful for functionalizations at C7 of 4-hydroxy-6-methyl-2-pyrone, or triacetic acid, are described here. This method was applied to the synthesis of annularin E.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd02c41b9f5cf046920233f5acd4a4c
https://doi.org/10.1055/s-2007-965925
https://doi.org/10.1055/s-2007-965925
Publikováno v:
Organic Letters. 8:777-780
[reaction: see text] An enantioselective total synthesis of (-)-cylindricine C is described, featuring a diastereoselective intramolecular aza-[3 + 3] annulation strategy and an interesting halohydrin formation of the C4-5 olefin for construction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7425c1dba200d7a52920e3bffbd805e9
https://doi.org/10.1021/ol053059p
https://doi.org/10.1021/ol053059p
Publikováno v:
The Journal of Organic Chemistry. 70:3898-3902
[reaction: see text] Details of problems and solutions encountered during the development of an enantioselective total synthesis of (+)-cylindricine C are described here. The total synthesis itself was accomplished in 8 steps, featuring an N-acylimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa327b44b5ef897e1f2bcf73562cb33
https://doi.org/10.1021/jo0501846
https://doi.org/10.1021/jo0501846
Publikováno v:
The Journal of Organic Chemistry. 68:644-647
Azaheterocyclic compounds are interesting and medicinally relevant targets. Herein we disclose an improved synthesis into the oxazepine and thiazepine ring systems. The key step in the synthesis exploits recent advancements in the palladium-catalyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9af9de627f444bcb70503983ac7d967
https://doi.org/10.1021/jo026546g
https://doi.org/10.1021/jo026546g
Autor:
Nan Lin, Jacob J. Swidorski, Glen C. Gullickson, Aleksey V. Kurdyumov, Nadiya Sydorenko, Richard P. Hsung, Kevin P. Cole
Publikováno v:
Organic Letters. 8:191-193
[reaction: see text] A Lewis acid-catalyzed formal cycloaddition of alpha,beta-unsaturated aldehydes with 6-methyl-4-hydroxy-2-pyrone, 1,3-diketones, and vinylogous silyl esters is described here.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639dfd84fe12f89962cdea6e377a635d
https://doi.org/10.1021/ol0523042
https://doi.org/10.1021/ol0523042
Autor:
Jiashi Wang, Jacob J. Swidorski, Jennifer M. Kuyava, Nadiya Sydorenko, Jia Liu, Richard P. Hsung, Heather A. Coverdale
Publikováno v:
ChemInform. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::617c07ce514dd3b85166651a0e80990e
https://doi.org/10.1002/chin.200724166
https://doi.org/10.1002/chin.200724166