Výsledky vyhledávání - "Jacob J. Robino"

Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques

Autor: Suhas Sureshchandra, Chi N. Chan, Jacob J. Robino, Lindsay K. Parmelee, Michael J. Nash, Stephanie R. Wesolowski, Eric M. Pietras, Jacob E. Friedman, Diana Takahashi, Weining Shen, Xiwen Jiang, Jon D. Hennebold, Devorah Goldman, William Packwood, Jonathan R. Lindner, Charles T. Roberts, Benjamin J. Burwitz, Ilhem Messaoudi, Oleg Varlamov

Publikováno v: Stem Cell Reports. 17:2595-2609

Maternal obesity adversely impacts the in utero metabolic environment, but its effect on fetal hematopoiesis remains incompletely understood. During late development, the fetal bone marrow (FBM) becomes the major site where macrophages and B lymphocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d95d9238fc5f4baa9c3d2b6867dfa8
https://doi.org/10.1016/j.stemcr.2022.10.003

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Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-independent Glucose Uptake via Extracellular Vesicles

Autor: Clair Crewe, Shiuhwei Chen, Dawei Bu, Christy M. Gliniak, Ingrid Wernstedt Asterholm, Xin Xin Yu, Nolwenn Joffin, Camila O. de Souza, Jan-Bernd Funcke, Da Young Oh, Oleg Varlamov, Jacob J. Robino, Ruth Gordillo, Philipp E. Scherer

Caveolin-1 (cav1) is an important structural and signaling component of plasma membrane invaginations called caveolae and is abundant in adipocytes. As previously reported, adipocyte-specific ablation of the cav1 gene (ad-cav1KO mouse) does not resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931fd98b67fdf48c916b91e341dd076a
https://doi.org/10.2337/figshare.20359713.v1

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Single‐Cell Sorting of Non‐human Primate Adipocytes with Large‐particle Flow Cytometry

Autor: Oleg Varlamov, Jacob J. Robino, Yongwoon Kim

Publikováno v: Current Protocols. 1

Fluorescence-activated cell sorting enables separation and analysis of heterogeneous cell populations based on size, granularity, and fluorescence intensity. Cell sorting has been widely used for isolation of cells that are ∼10 to 25 μm in diamete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e8882f78020253bcf5e6687a039e71
https://doi.org/10.1002/cpz1.271

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LBSUN86 Effects Of Hyperandrogenemia And Western-style Diet On Rhesus Macaque Tissue-resident Memory T-cells And Their Potential Role In Controlling Local Inflammation And Insulin Sensitivity

Autor: Oleg Varlamov, Sofia Yusova, Cecily V Bishop, Jacob J Robino, Diana Takahashi, Charles Roberts, Ov D Slayden, Benjamin J Burwitz, Jon D Hennebold

Publikováno v: Journal of the Endocrine Society. 6:A6-A6

We have previously demonstrated that the combination of chronic hyperandrogenemia (elevated circulating testosterone; T) and an obesogenic Western-style diet (WSD) exerts synergistic effects on the metabolic and reproductive axis, leading to the deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1df229c2ab8f9cfa5b53c477f3ad334b
https://doi.org/10.1210/jendso/bvac150.012

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LBSUN129 Adipose Tissue Analysis Toolkit (at-at): An Imagej Plugin For Automated Analysis Of Adipocyte Number, Size, And Pericellular Fibrosis In Histological Sections

Autor: Jacob J Robino, Dawei Bu, Bianca C Field, Philipp E Scherer, Charles T Roberts, Oleg Varlamov

Publikováno v: Journal of the Endocrine Society. 6:A4-A4

Obesity-induced pathological expansion of white adipose tissue (WAT) involves adipocyte hypertrophy that occurs in tandem with the development of pericellular fibrosis. Other pathophysiological states, such as cancer and HIV, are also associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::275211d5f2f4894645e0c88fd05f7707
https://doi.org/10.1210/jendso/bvac150.007

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Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques

Autor: Suhas Sureshchandra, Chi N. Chan, Jacob J. Robino, Lindsay K. Parmelee, Michael J. Nash, Stephanie R. Wesolowski, Eric M. Pietras, Jacob E. Friedman, Diana Takahashi, Weining Shen, Jon D. Hennebold, Devorah Goldman, William Packwood, Jonathan R Lindner, Charles T. Roberts, Benjamin J. Burwitz, Ilhem Messaoudi, Oleg Varlamov

BackgroundMaternal obesity adversely impacts the in utero metabolic environment and offspring’s health, but its effect on fetal hematopoiesis and immune cell development remains incompletely understood, particularly in models that resemble human de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::870dfbd8cdc867038587b857fa540d07
https://doi.org/10.1101/2021.04.26.441556

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Spatial and biochemical interactions between bone marrow adipose tissue and hematopoietic stem and progenitor cells in rhesus macaques

Autor: Jacob J. Robino, Benjamin J. Burwitz, Charles T. Roberts, Oleg Varlamov, Sara Rosario, Lindsey B. Crawford, Nathalie Pamir, Peter Kurre

Publikováno v: Bone

Recent developments in in situ microscopy have enabled unparalleled resolution of the architecture of the bone marrow (BM) niche for murine hematopoietic stem and progenitor cells (HSPCs). However, the extent to which these observations can be extrap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c26ab286a79316540ad1a34fd85e0a
https://pubmed.ncbi.nlm.nih.gov/31972314

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