Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Jacob J. Adashek"'
Multi‐omic analysis in carcinoma of unknown primary (CUP): therapeutic impact of knowing the unknown
Autor:
Shumei Kato, Sophia Gumas, Jacob J. Adashek, Ryosuke Okamura, Suzanna Lee, Jason K. Sicklick, Razelle Kurzrock
Publikováno v:
Molecular Oncology, Vol 18, Iss 4, Pp 956-968 (2024)
Carcinoma of unknown primary (CUP) is a difficult‐to‐manage malignancy. Multi‐omic profiles and treatment outcome vs. degree of precision matching were assessed. Tumours underwent next‐generation sequencing (NGS) [tissue and/or blood‐derive
Externí odkaz:
https://doaj.org/article/2f709749a5e648c68c0ec4e1799e0aa3
Autor:
Jacob J. Adashek, Chinmayi Pandya, Nicholas J. Maragakis, Pradip De, Philip R. Cohen, Shumei Kato, Razelle Kurzrock
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Neuregulin-1 (NRG1) is implicated in both cancer and neurologic diseases such as amyotrophic lateral sclerosis (ALS); however, to date, there has been little cross-field discussion between neurology and oncology in regard to these
Externí odkaz:
https://doaj.org/article/5510840f22664d2da2e8c1900f898037
Autor:
Jacob J. Adashek, Razelle Kurzrock
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-6 (2023)
Abstract In oncology clinical trials, many patients spend their final months at a central clinical trial facility far from home for “mandatory” protocol visits/diagnostic testing. Studies suggest that the travel strain may be greatest among patie
Externí odkaz:
https://doaj.org/article/bc2b244d015442bfb1c9ad91eb41be04
Autor:
Mahati Paravathaneni, Houssein Safa, Vidhu Joshi, Monica K. Tamil, Jacob J. Adashek, Filip Ionescu, Savan Shah, Juskaran S. Chadha, Scott Gilbert, Brandon Manley, Adele Semaan, Heather S.L. Jim, Denise Kalos, Youngchul Kim, Philippe E. Spiess, Jad Chahoud
Publikováno v:
EClinicalMedicine, Vol 68, Iss , Pp 102413- (2024)
Summary: Background: Standardized, high-quality PRO data reporting is crucial for patient centered care in the field of oncology, especially in clinical trials that establish standard of care. This study evaluated PRO endpoint design, conduct and rep
Externí odkaz:
https://doaj.org/article/f8367ce4344b45879a82f1322cc3d99e
Autor:
Jungah Lim, Razelle Kurzrock, Daisuke Nishizaki, Hirotaka Miyashita, Jacob J. Adashek, Suzanna Lee, Sarabjot Pabla, Mary Nesline, Jeffrey M. Conroy, Paul DePietro, Scott M. Lippman, Shumei Kato
Publikováno v:
Cancer Medicine, Vol 13, Iss 1, Pp n/a-n/a (2024)
Abstract Background T‐cell immunoglobulin and mucin domain‐containing protein 3 (TIM‐3), an immune checkpoint receptor, dampens immune function. TIM‐3 antagonists have entered the clinic. Methods We analyzed TIM‐3 transcriptomic expression
Externí odkaz:
https://doaj.org/article/faba3e63388e469f81fc01e32dc0a947
Autor:
Jacob J. Adashek, Shumei Kato, Daisuke Nishizaki, Hirotaka Miyashita, Pradip De, Suzanna Lee, Sarabjot Pabla, Mary Nesline, Jeffrey M. Conroy, Paul DePietro, Scott Lippman, Razelle Kurzrock
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13155-13166 (2023)
Abstract Background Lymphocyte activation gene 3 (LAG‐3) or CD223 is a transmembrane protein that serves as an immune checkpoint which attenuates T‐cell activation. Many clinical trials of LAG‐3 inhibitors have had modest effects, but recent da
Externí odkaz:
https://doaj.org/article/cfe72fc33e194e9395740e5950d4b95c
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-4 (2023)
Abstract The advent of next-generation sequencing (NGS) has allowed for the identification of novel therapeutic targets for patients with uncommon cancers. It is well known that fusion translocations are potent driver of cancer pathogenesis and can r
Externí odkaz:
https://doaj.org/article/785348aab730455bb853b30f998a0404
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 6451-6465 (2023)
Abstract Although the “abscopal phenomenon” has been described several decades ago, this phenomenon lately has been obtaining momentous traction with the dawn of immune‐based therapies. There has been increased cross talk among radiation oncolo
Externí odkaz:
https://doaj.org/article/2effa015698844789cf7f24758000e53
Autor:
Justin Shaya, Shumei Kato, Jacob J. Adashek, Hitendra Patel, Paul T. Fanta, Gregory P. Botta, Jason K. Sicklick, Razelle Kurzrock
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-8 (2023)
Abstract Despite progress, 2-year pancreatic cancer survival remains dismal. We evaluated a biomarker-driven, combination/N-of-one strategy in 18 patients (advanced/metastatic pancreatic cancer) (from Molecular Tumor Board). Targeted agents administe
Externí odkaz:
https://doaj.org/article/a2de75649db9401d9bfbe553e7066915
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 1-6 (2022)
Next-generation sequencing data is fundamentally changing the clinical management of patients with cancer. The most frequent genomic alterations in malignancy are mutations and amplifications, with a subset of tumors having multiple amplifications
Externí odkaz:
https://doaj.org/article/56cd5d1096b14a908af6891a13a48c19