Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Jacob J Orme"'
Autor:
Svetomir Markovic, Haidong Dong, Nathan Foster, Jacob J Orme, Sean S Park, Jeffrey L Winters, Tara M Davidson, Fabrice Lucien
Publikováno v:
BMJ Open, Vol 12, Iss 5 (2022)
Background Patients with metastatic melanoma rely on PD-(L)1 immunotherapy, but only one-third of patients experience treatment response and all initial responders eventually develop resistance. Tumour-derived extracellular vesicles expressing Progra
Externí odkaz:
https://doaj.org/article/0b6f47902c314b00ac2a6c0aafe30a5c
Autor:
Haidong Dong, Svetomir N Markovic, Aaron S Mansfield, Jacob J Orme, Elizabeth Ann L Enninga, Fabrice Lucien-Matteoni, Heather Dale, Edwin Burgstaler, Susan M Harrington, Matthew K Ball, Sean S Park, Mathew S Block, Yiyi Yan, Roxana S Dronca, Jeffrey L Winters
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Trans-acting programmed death-ligand 1 (PD-L1) derives from malignant cells in three known forms. High levels of secreted splice variant PD-L1 (sPD-L1), ADAM10/ADAM17-shed sPD-L1, and PD-L1-positive extracellular vesicles (evPD-L1) each pr
Externí odkaz:
https://doaj.org/article/12cda94bbdc0496a8a76193abb6aa4f3
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161682 (2016)
Wnt/β-catenin signaling is relatively understudied in immunity and autoimmunity. β-catenin blocks inflammatory mediators and favors tolerogenic dendritic cell (DC) phenotypes. We show here that leukocytes from lupus-prone mice and SLE patients expr
Externí odkaz:
https://doaj.org/article/1c6fd19cc2c5450488525dcfd528d663
Autor:
Zhenlin Huang, Xiang Li, Bo Tang, Hao Li, Jianong Zhang, Rui Sun, Jian Ma, Yunqian Pan, Binyuan Yan, Yingke Zhou, Donglin Ding, Yuqian Yan, Rafael Jimenez, Jacob J. Orme, Xin Jin, Jinjian Yang, Haojie Huang, Zhankui Jia
Publikováno v:
Cancer Research. 83:875-889
Retinoblastoma (RB) protein can exert tumor suppressor functions even when it becomes phosphorylated. It is thus essential to understand how phosphorylated RB (p-RB) expression and function are regulated. Here, we demonstrated that RING finger domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3d7871272cab78d3adfab9e014e156e
https://doi.org/10.1158/0008-5472.can-22-0264
https://doi.org/10.1158/0008-5472.can-22-0264
Autor:
Daniel S. Childs, David A. Helfinstine, Lindsey Sangaralingham, Jacob J. Orme, Ciara C. O'Sullivan, Charles L. Loprinzi, Kathryn J. Ruddy
Publikováno v:
JCO Oncology Practice. 18:e1953-e1960
PURPOSE: For the past 5 years, most major antiemesis guidelines have included olanzapine-containing regimens among the recommended options for prophylaxis with highly emetogenic chemotherapy (HEC). We analyzed the uptake of olanzapine in clinical pra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3595fa240643b4d10d96e0531916527
https://doi.org/10.1200/op.22.00389
https://doi.org/10.1200/op.22.00389
Autor:
Fabrice Lucien, Yohan Kim, Jing Qian, Jacob J. Orme, Henan Zhang, Ali Arafa, Feven Abraha, Ishwor Thapa, Erik J. Tryggestad, William S. Harmsen, Jorgena Kosti, Hesham Ali, Val J. Lowe, Geoff B. Johnson, Eugene D. Kwon, Haidong Dong, Sean S. Park
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 114:725-737
SABR has demonstrated clinical benefit in oligometastatic prostate cancer. However, the risk of developing new distant metastatic lesions remains high, and only a minority of patients experience durable progression-free response. Therefore, there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f96eba1b2e6b78fdda0250afe2f00df
https://doi.org/10.1016/j.ijrobp.2022.05.037
https://doi.org/10.1016/j.ijrobp.2022.05.037
Autor:
Aakash P, Desai, Caleb J, Scheckel, Leah C, Soderberg, Chelsee J, Jensen, Jacob J, Orme, Sri H, Tella, Anuhya, Kommalapati, Joshua C, Pritchett, Nandita, Khera, Amit, Mahipal, Ronald S, Go
Publikováno v:
JCO Oncology Practice. 18:e1247-e1254
PURPOSE: Precision oncology promises improved outcomes but the cost-effectiveness and accessibility of targeted therapies is debatable. We report price change patterns from 2015 to 2019 for several oral anticancer medications for common solid tumor m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69943c2553d56c6fd6577b53d75bd45
https://doi.org/10.1200/op.21.00847
https://doi.org/10.1200/op.21.00847
Autor:
David C. Kochan, Paul J. Novotny, Elizabeth J. Cathcart-Rake, Jacob J. Orme, Amye J. Tevaarwerk, Kathryn J. Ruddy, Daniel S. Childs
Publikováno v:
Supportive Care in Cancer. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ba4d772176eff44de230489acb5d828
https://doi.org/10.1007/s00520-023-07775-7
https://doi.org/10.1007/s00520-023-07775-7
Autor:
Sean S. Park, Haidong Dong, Eugene D. Kwon, Thomas M. Pisansky, Kenneth R. Olivier, Mark A. Nathan, Geoffrey B. Johnson, Brian A. Costello, William S. Harmsen, J. Fernando Quevedo, Brian J. Davis, Matthew J. Iott, Debra H. Brinkmann, C. Richard Choo, Lance C. Pagliaro, Michael S. Bold, Erik J. Tryggestad, Fabrice Lucien, Val J. Lowe, B.J. Stish, Feven Abraha, Jacob J. Orme, Henan Zhang
Supplementary Table 3. Baseline TTR and changes after SBRT predict outcomes in oligometastatic CRPC. Median event-free survival survival (in months) and hazard ratio for each outcome and group is given, stratified by baseline TTR levels (left) or cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e76c3294f4aff55ec03320907158306
https://doi.org/10.1158/1078-0432.22484210.v1
https://doi.org/10.1158/1078-0432.22484210.v1
Autor:
Sean S. Park, Haidong Dong, Eugene D. Kwon, Thomas M. Pisansky, Kenneth R. Olivier, Mark A. Nathan, Geoffrey B. Johnson, Brian A. Costello, William S. Harmsen, J. Fernando Quevedo, Brian J. Davis, Matthew J. Iott, Debra H. Brinkmann, C. Richard Choo, Lance C. Pagliaro, Michael S. Bold, Erik J. Tryggestad, Fabrice Lucien, Val J. Lowe, B.J. Stish, Feven Abraha, Jacob J. Orme, Henan Zhang
Supplementary Table 1. PSA progression by number of sites treated. 1Kaplan-Meier method; 2Cox model; 3Logrank test; 4Wald Chi-Square test.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435496c52206d4162494014aa5efdeaa
https://doi.org/10.1158/1078-0432.22484216
https://doi.org/10.1158/1078-0432.22484216