Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Jacob J, Orme"'
Autor:
Mohamed E. Ahmed, Ahmed M. Mahmoud, Guiseppe Reitano, Wael Zeina, Kelly Lehner, Carter A. Day, Irbaz Riaz, Daniel S. Childs, Jacob J. Orme, A. Tuba Kendi, Geoffrey B. Johnson, R. Jeffrey Karnes, Eugene D. Kwon, Jack R. Andrews
Publikováno v:
European Urology Open Science, Vol 66, Iss , Pp 38-45 (2024)
Background and objective: Visceral metastatic disease in prostate cancer patients conveys a poor prognosis. Using advanced imaging techniques, studies have demonstrated increasing detection rates of visceral metastasis. Visceral metastases are now se
Externí odkaz:
https://doaj.org/article/8d4eb652bd404f21a76df8cc20d2d208
Autor:
Gokce Belge Bilgin, Cem Bilgin, Daniel S. Childs, Jacob J. Orme, Brian J. Burkett, Ann T. Packard, Derek R. Johnson, Matthew P. Thorpe, Irbaz Bin Riaz, Thorvardur R. Halfdanarson, Geoffrey B. Johnson, Oliver Sartor, Ayse Tuba Kendi
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMany patients use artificial intelligence (AI) chatbots as a rapid source of health information. This raises important questions about the reliability and effectiveness of AI chatbots in delivering accurate and understandable information.Pu
Externí odkaz:
https://doaj.org/article/7ca738fae743479887d0e6ee453667e6
Autor:
Ahmed M. Mahmoud, Mohamed E. Ahmed, A. Tuba Kendi, Matthew Thorpe, Geoffrey B. Johnson, Irbaz Bin Riaz, Jacob J. Orme, Eugene D. Kwon, Jack R. Andrews, Daniel S. Childs
Publikováno v:
BJUI Compass, Vol 5, Iss 2, Pp 319-324 (2024)
Abstract Background For men with prostate cancer, radiographic progression may occur without a concordant rise in prostate‐specific antigen (PSA). Our study aimed to assess the prevalence of radiographic progression using C‐11 choline positron em
Externí odkaz:
https://doaj.org/article/29b24f73a0de43fead3611b2e5a728e1
Autor:
Ahmed M. Mahmoud, Igor Frank, Jacob J. Orme, Roxane R. Lavoie, Prabin Thapa, Brian A. Costello, John C. Cheville, Sounak Gupta, Haidong Dong, Fabrice Lucien
Publikováno v:
BMC Urology, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Introduction and objectives PD-L1 and B7-H3 have been found to be overexpressed in urothelial carcinoma (UC) of the urinary bladder. Recent studies have also demonstrated that B7-H3 and PD-L1 can promote resistance to platinum-based drugs bu
Externí odkaz:
https://doaj.org/article/29c7a111de8b47c886fa082c98b34c24
Autor:
Yundong He, Ting Wei, Zhenqing Ye, Jacob J. Orme, Dong Lin, Haoyue Sheng, Ladan Fazli, R. Jeffrey Karnes, Rafael Jimenez, Liguo Wang, Liewei Wang, Martin E. Gleave, Yuzhuo Wang, Lei Shi, Haojie Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Resistance to second generation anti-androgen therapies such as enzalutamide (ENZ) can emerge in prostate cancer patients. Here, the authors identify an ENZ-resistant mechanism driven by AR-dependent transcription of noncanonical targets that make re
Externí odkaz:
https://doaj.org/article/00b4af7118804738bdce75145ea247c5
Autor:
Svetomir Markovic, Haidong Dong, Nathan Foster, Jacob J Orme, Sean S Park, Jeffrey L Winters, Tara M Davidson, Fabrice Lucien
Publikováno v:
BMJ Open, Vol 12, Iss 5 (2022)
Background Patients with metastatic melanoma rely on PD-(L)1 immunotherapy, but only one-third of patients experience treatment response and all initial responders eventually develop resistance. Tumour-derived extracellular vesicles expressing Progra
Externí odkaz:
https://doaj.org/article/0b6f47902c314b00ac2a6c0aafe30a5c
Autor:
Zhenlin Huang, Xiang Li, Bo Tang, Hao Li, Jianong Zhang, Rui Sun, Jian Ma, Yunqian Pan, Binyuan Yan, Yingke Zhou, Donglin Ding, Yuqian Yan, Rafael Jimenez, Jacob J. Orme, Xin Jin, Jinjian Yang, Haojie Huang, Zhankui Jia
Publikováno v:
Cancer Research. 83:875-889
Retinoblastoma (RB) protein can exert tumor suppressor functions even when it becomes phosphorylated. It is thus essential to understand how phosphorylated RB (p-RB) expression and function are regulated. Here, we demonstrated that RING finger domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3d7871272cab78d3adfab9e014e156e
https://doi.org/10.1158/0008-5472.can-22-0264
https://doi.org/10.1158/0008-5472.can-22-0264
Autor:
Haidong Dong, Svetomir N Markovic, Aaron S Mansfield, Jacob J Orme, Elizabeth Ann L Enninga, Fabrice Lucien-Matteoni, Heather Dale, Edwin Burgstaler, Susan M Harrington, Matthew K Ball, Sean S Park, Mathew S Block, Yiyi Yan, Roxana S Dronca, Jeffrey L Winters
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Trans-acting programmed death-ligand 1 (PD-L1) derives from malignant cells in three known forms. High levels of secreted splice variant PD-L1 (sPD-L1), ADAM10/ADAM17-shed sPD-L1, and PD-L1-positive extracellular vesicles (evPD-L1) each pr
Externí odkaz:
https://doaj.org/article/12cda94bbdc0496a8a76193abb6aa4f3
Autor:
Jacob J. Orme, Khalid A. Jazieh, Tiancheng Xie, Susan Harrington, Xin Liu, Matthew Ball, Benjamin Madden, M. Cristine Charlesworth, Tariq U. Azam, Fabrice Lucien, Bharath Wootla, Yanli Li, Jose Caetano Villasboas, Aaron S. Mansfield, Roxana S. Dronca, Haidong Dong
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown. Here we uncover a novel
Externí odkaz:
https://doaj.org/article/d1814e9bd1a546f8bc1069d53e116a3e
Autor:
Daniel S. Childs, David A. Helfinstine, Lindsey Sangaralingham, Jacob J. Orme, Ciara C. O'Sullivan, Charles L. Loprinzi, Kathryn J. Ruddy
Publikováno v:
JCO Oncology Practice. 18:e1953-e1960
PURPOSE: For the past 5 years, most major antiemesis guidelines have included olanzapine-containing regimens among the recommended options for prophylaxis with highly emetogenic chemotherapy (HEC). We analyzed the uptake of olanzapine in clinical pra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3595fa240643b4d10d96e0531916527
https://doi.org/10.1200/op.22.00389
https://doi.org/10.1200/op.22.00389