Parkinson’s Disease: Changes in Daily Life

Autor: Jacob I. Sage

Publikováno v: Changes in the Brain ISBN: 9780387981871

Parkinson’s disease is a progressive brain disease produced by degeneration of neurons in the substantia nigra and other brain nuclei. The cause is unknown but environmental and genetic factors are thought to play a role. Clinical symptoms and sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b05180dd8fafd58ecd7dcdb2c41fb95f
https://doi.org/10.1007/978-0-387-98188-8_4

A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease

Autor: Margaret Marie Cox, Stephanie Sendek, Margaret F. Turk, Julie H. Carter, Susan C. Fagan, Lorelei Derwent, Oksana Suchowersky, Jay S. Schneider, Linda Paul, Gwyn Vernon, Stephen Gollomp, Karl Kieburtz, Debbie Baker, I. Van Bodis-Wollner, Germaine McInnes, Marian A. Perez, G. Webster Ross, Katharine Pabst, Jorge L. Juncos, Chad W. Christine, Jessie Roth, Joseph M. Savitt, Peter A LeWitt, Hubert H. Fernandez, Matthew Brodsky, Mark F. Lew, Jay M. Gorell, Natividad R. Stover, Paulo Guimaraes, Andrew Feigin, Anita Blenke, Martha Nance, Elizabeth Hayes, Andrew Siderowf, W.R. Wayne Martin, Tammie Kelsey, Susan Bennett, Sharon McCarthy, Charles H. Adler, Beverly Olsen, Pauline LeBlanc, Richard B. Dewey, Rodger J. Elble, Richard S. Burns, Carlos Singer, Amy Parsons, John W. Taylor, Tracy Stewart, Maryan DeAngelis, Barbara C. Tilley, William J. Weiner, Brad A. Racette, Wendy R. Galpern, Michael J. Aminoff, Kapil D. Sethi, Jayaraman Rao, Robert A. Hauser, Debbie Fraser, Connie Kawai, David Coffey, Kelly E. Lyons, Kristine Wernette, Becky Dunlop, Holly Delgado, Marlene Lind, Rajesh Pahwa, Chris Weaver, Ray L. Watts, Patricia Deppen, Ryan J. Uitti, Marwan N. Sabbagh, Lynn Marlor, Joann Belden, Burton L. Scott, Theresa McClain, Roger L. Albin, John Y. Fang, Zoran Obradov, Yuko Y. Palesch, Maureen Cook, Pamela Andrews, Jeana Jaglin, Joanne Wojcieszek, Mary Louise Musante Weeks, Susan Peterson, James H. Bower, Maureen A. Leehey, Joanne Field, Lisa M. Shulman, Caroline M. Tanner, Jacob I. Sage, Jordan J. Elm, Joseph Jankovic, Patrick D. Mauldin, Aileen Shinaman, Peng Huang, G. Frederick Wooten, Alicia Brocht, Gordon H. Brown, Peggy Roberge, Dorothy Shearon, Buff Dill, Margaret F. Keller, Charlene Young, Christine Hunter, Janis M. Miyasaki, Susan Torgrimson, Cornelia Kamp, Brigid Hayward, Christopher G. Goetz, Emily Kosa, Marilyn Flewellen, David Simon, Rebecca McMurray, Sue Reichwein, Jacci Bainbridge, Robert W. Hamill, Stephanie Terashita, Kathleen M. Shannon, Frederick Wooten, Danna Jennings, Shana Krstevska, Bernard Ravina

Publikováno v: Neurology. 68:20-28

Objective: To determine if future studies of coenzyme Q10 and GPI-1485 in Parkinson disease (PD) may be warranted. Methods: We conducted a randomized, double-blind, calibrated futility clinical trial of coenzyme Q10 and GPI-1485 in early untreated PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f17ff7b2eee66f71cf67f7561841fe
https://doi.org/10.1212/01.wnl.0000250355.28474.8e

The role of dopamine in cognitive sequence learning: evidence from Parkinson’s disease

Autor: Jacob I. Sage, Steven Grossman, Catherine E. Myers, Mark A. Gluck, Daphna Shohamy

Publikováno v: Behavioural Brain Research. 156:191-199

Electrophysiological and computational studies suggest that nigro-striatal dopamine may play an important role in learning about sequences of environmentally important stimuli, particularly when this learning is based upon step-by-step associations b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c35dcb4676afa4a9e3a0a735b3d0ce
https://doi.org/10.1016/j.bbr.2004.05.023

Pain in Parkinson’s disease

Autor: Jacob I. Sage

Publikováno v: Current Treatment Options in Neurology. 6:191-200

Pain is reported by nearly 50% of patients with Parkinson's disease. In some patients, it can be more debilitating than the motor deficits. In order to identify the appropriate treatment strategy for each patient, it is useful to categorize pain synd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b18e7b2bddf9a4dd379c8065f76ce1
https://doi.org/10.1007/s11940-004-0011-x

Behavioral inflexibility and motor dedifferentiation in persons with Parkinson's disease: bilateral coordination deficits during a unimanual reaching task

Autor: Jacob I. Sage, S. Lee Hong, Elizabeth B. Torres, Shinichi Amano

Publikováno v: Neuroscience letters. 585

We evaluated kinematics of people with Parkinson's disease (PD) and age-matched controls during cued and uncued reaching movements. Maximum hand velocity, its variability and shoulder-to-shoulder coupling, quantified by phase locking value (PLV), wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74caa5164b0b8c200e9a142849783a8
https://pubmed.ncbi.nlm.nih.gov/25451729