Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jacob Househam"'
Autor:
Alice Antonello, Riccardo Bergamin, Nicola Calonaci, Jacob Househam, Salvatore Milite, Marc J. Williams, Fabio Anselmi, Alberto d’Onofrio, Vasavi Sundaram, Alona Sosinsky, William C. H. Cross, Giulio Caravagna
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-40 (2024)
Abstract Copy number alterations (CNAs) are among the most important genetic events in cancer, but their detection from sequencing data is challenging because of unknown sample purity, tumor ploidy, and general intra-tumor heterogeneity. Here, we pre
Externí odkaz:
https://doaj.org/article/58afabce18a849ecb410852f49a33e9f
Autor:
Daniel P. Hart, Nazmiye Uzun, Stuart Skelton, Alison Kakoschke, Jacob Househam, David S. Moss, Adrian J. Shepherd
Publikováno v:
Haematologica, Vol 104, Iss 3 (2019)
Single missense mutations in the F8 gene encoding the coagulation protein factor VIII give rise predominantly to non-severe hemophilia A. Despite only a single amino acid sequence difference between the replacement, therapeutic factor VIII and the pa
Externí odkaz:
https://doaj.org/article/379523a9774140298a5becd869f83654
Autor:
Melissa Barroux, Jacob Househam, Eszter Lakatos, Tahel Ronel, Ann-Marie Baker, Henrike Salié, Max Mossner, Kane Smith, Chris Kimberley, Salpie Nowinski, Alison Berner, Vinaya Gunasri, Marnix Jansen, Giulio Caravagna, Katja Steiger, Julia Slotta-Huspenina, Wilko Weichert, Markus Alberstmeier, Benny Chain, Helmut Friess, Bertram Bengsch, Roland Schmid, Jens Siveke, Michael Quante, Trevor Graham
Locally advanced oesophageal adenocarcinoma (EAC) remains difficult to treat because of common resistance to neoadjuvant therapy and high recurrence rates. The ecological and evolutionary dynamics responsible for treatment failure are incompletely un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23626ec121eaf552ab7c2479aaea43d5
https://doi.org/10.21203/rs.3.rs-2738048/v1
https://doi.org/10.21203/rs.3.rs-2738048/v1
Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues
Autor:
Calum Gabbutt, Ryan O. Schenck, Daniel J. Weisenberger, Christopher Kimberley, Alison Berner, Jacob Househam, Eszter Lakatos, Mark Robertson-Tessi, Isabel Martin, Roshani Patel, Susan K. Clark, Andrew Latchford, Chris P. Barnes, Simon J. Leedham, Alexander R. A. Anderson, Trevor A. Graham, Darryl Shibata
Publikováno v:
Nature Biotechnology. 40:720-730
Molecular clocks that record cell ancestry mutate too slowly to measure the short-timescale dynamics of cell renewal in adult tissues. Here, we show that fluctuating DNA methylation marks can be used as clocks in cells where ongoing methylation and d
Autor:
Ian Tomlinson, Alex Cornish, Andreas Gruber, Richard Houlston, Amit Sud, Philip Law, Eszter Lakatos, Richard Culliford, Jacob Househam, Trevor Graham, Henry Wood, Philip Quirke, Nuria Lopez-Bigas, Claudia Arnedo-Pac, Daniel Chubb, Maire Ni Leathlobhair, Boris Noyvert, Ben Kinnersley, William Cross, Nirupa Murugaesu, Alona Sosinsky, Jonathan Mitchell, Ludmil Alexandrov, Luis Zapata, Juan Fernandez-Tajes, Steve Thorn, Kitty Sherwood, Guler Gul, Aliah Hawari, Andrea Sottoriva, David Church, Giulio Caravagna, David Wedge, Anna Frangou
To characterise the somatic alterations in colorectal cancer (CRC), we conducted whole-genome sequencing analysis of 2,023 tumours. We provide the most detailed high-resolution map to date of somatic mutations in CRC, and demonstrate associations wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d667ff9c3f5ecfc24c3d589c03f2d1a
https://doi.org/10.21203/rs.3.rs-2273265/v1
https://doi.org/10.21203/rs.3.rs-2273265/v1
Autor:
Melissa Barroux, Jacob Househam, Eszter Lakatos, Tahel Ronel, Ann-Marie Baker, Henrike Salié, Max Mossner, Kane Smith, Chris Kimberley, Salpie Nowinski, Alison Berner, Vinaya Gunasri, Marnix Jansen, Giulio Caravagna, Julia Slotta-Huspenina, Wilko Weichert, Markus Alberstmeier, Benny Chain, Helmut Friess, Bertram Bengsch, Roland M. Schmid, Jens T. Siveke, Michael Quante, Trevor A. Graham
Publikováno v:
Cancer Research. 83:4539-4539
Introduction: Locally advanced esophageal adenocarcinoma (EAC) remains difficult to treat, and resistance is common. The ecological and evolutionary dynamics responsible for treatment failure are incompletely understood. Aim & Methods: We performed a
Autor:
Timon Heide, Jacob Househam, George D. Cresswell, Inmaculada Spiteri, Claire Lynn, Maximilian Mossner, Chris Kimberley, Javier Fernandez-Mateos, Bingjie Chen, Luis Zapata, Chela James, Iros Barozzi, Ketevan Chkhaidze, Daniel Nichol, Vinaya Gunasri, Alison Berner, Melissa Schmidt, Eszter Lakatos, Ann-Marie Baker, Helena Costa, Miriam Mitchinson, Rocco Piazza, Marnix Jansen, Giulio Caravagna, Daniele Ramazzotti, Darryl Shibata, John Bridgewater, Manuel Rodriguez-Justo, Luca Magnani, Trevor A. Graham, Andrea Sottoriva
Colorectal malignancies are a leading cause of cancer-related death1 and have undergone extensive genomic study2,3. However, DNA mutations alone do not fully explain malignant transformation4–7. Here we investigate the co-evolution of the genome an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5ce292f9f3a649633e0bd1f4fb0f20
https://hdl.handle.net/11368/3033100
https://hdl.handle.net/11368/3033100
Autor:
Jacob Househam, Timon Heide, George D. Cresswell, Inmaculada Spiteri, Chris Kimberley, Luis Zapata, Claire Lynn, Chela James, Maximilian Mossner, Javier Fernandez-Mateos, Alessandro Vinceti, Ann-Marie Baker, Calum Gabbutt, Alison Berner, Melissa Schmidt, Bingjie Chen, Eszter Lakatos, Vinaya Gunasri, Daniel Nichol, Helena Costa, Miriam Mitchinson, Daniele Ramazzotti, Benjamin Werner, Francesco Iorio, Marnix Jansen, Giulio Caravagna, Chris P. Barnes, Darryl Shibata, John Bridgewater, Manuel Rodriguez-Justo, Luca Magnani, Andrea Sottoriva, Trevor A. Graham
Genetic and epigenetic variation, together with transcriptional plasticity, contribute to intratumour heterogeneity1. The interplay of these biological processes and their respective contributions to tumour evolution remain unknown. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9fb758339ef8ee25db6195aead51c0
https://hdl.handle.net/11368/3033099
https://hdl.handle.net/11368/3033099
Autor:
Inma Spiteri, Andrea Sottoriva, Daniel Nichol, Maximilian Mossner, Manuel Rodriguez-Justo, Timon Heide, Luca Magnani, Javier Fernández-Mateos, Chela James, Christopher Kimberley, Bingjie Chen, Marnix Jansen, Iros Barozzi, Kate Chkhaidze, Melissa Schmidt, Daniele Ramazzotti, Claire Lynn, Luis Zapata, Miriam Mitchinson, John Bridgewater, Ann-Marie Baker, Jacob Househam, Trevor A. Graham, Giulio Caravagna, Helena Costa, Darryl Shibata, Eszter Lakatos, George D. Cresswell, Alison May Berner
Colorectal malignancies are a leading cause of cancer death. Despite large-scale genomic efforts, DNA mutations do not fully explain malignant evolution. Here we study the co-evolution of the genome and epigenome of colorectal tumours at single-clone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b816f22ce1fa5e45de2836bcdc207480
https://doi.org/10.21203/rs.3.rs-797138/v1
https://doi.org/10.21203/rs.3.rs-797138/v1
Autor:
Luis Zapata, Melissa Schmidt, Maximilian Mossner, Marnix Jansen, Chris Kimberley, Miriam Mitchinson, Calum Gabbutt, Giulio Caravagna, Jacob Househam, Helena Costa, Alison May Berner, Inmaculada Spiteri, Bingjie Chen, Claire Lynn, George D. Cresswell, John Bridgewater, Manuel Rodriguez-Justo, Darryl Shibata, Timon Heide, Luca Magnani, Trevor A. Graham, Andrea Sottoriva, Daniel Nichol, Javier Fernández-Mateos, Ann-Marie Baker, Eszter Lakatos, Chela James
Cancer evolution is driven by natural selection acting upon phenotypic trait variation. However, the extent to which phenotypic variation within a tumour is a consequence of intra-tumour genetic heterogeneity remains undetermined. Here we show that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc61b0f47b8c0a0148b0e7543cf7a061
https://doi.org/10.1101/2021.07.18.451272
https://doi.org/10.1101/2021.07.18.451272