Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Jacob Hirdler"'
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Abstract 397: Mesenchymal stem cell-derived systemic NRG-1 mediates a targetable molecular switch in metastatic prostate cancer
Autor: Jacob Orme, Roman Thaler, Dejie Wang, Siven Chinniah, Jacob Hirdler, Fernando Quevedo, Lance Pagliaro, Kwon Eugene, Alan Bryce, Brian Costello, Haojie Huang, Sean Park
Publikováno v: Cancer Research. 82:397-397
NRG-1 signals through epidermal growth factor receptor (EGFR) family members. Despite promising preclinical data, HER2 blockade in prostate cancer has failed to improve outcomes in clinical trials.1-4 We have discovered a novel complex systemic role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::259a1ac758287bc2ea08575205e96978
https://doi.org/10.1158/1538-7445.am2022-397
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7
Abstract 504: NKG7 mRNA therapy increases the anti-tumor cytotoxicity of CD8 T cells
Autor: Henan Zhang, Ti Wen, Ying Li, Yiyi Yan, Jacob Hirdler, Whitney Barham, Cindy Liu, Joanina K. Gicobi, Fabrice Lucien-Matteoni, Haidong Dong
Publikováno v: Cancer Research. 81:504-504
Cytotoxic T lymphocytes (CTL's) are capable of killing tumor cells throughout the body, and can be stimulated to do so by a form of immunotherapy known as PD-1 checkpoint blockade. However, the majority of patients given anti-PD-1 therapeutics do not
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::756c28718e9d008a8739425e412416ec
https://doi.org/10.1158/1538-7445.am2021-504
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8
ANT2 (SLC25A5) balances the pro-apoptotic vs. effector signals of Bim in CD8 T cells
Autor: Joanina K Gicobi, Xiatong Yu, Roxana S. Dronca, Xin Liu, Whitney Barham, Ti Wen, Henan Zhang, Mojun Zhu, Susan M. Harrington, Vianca Vianzon, Jacob Hirdler, Haidong Dong
Publikováno v: The Journal of Immunology. 204:165.7-165.7
The immune response to anti-PD-1 therapy in cancer patients is not completely defined due to lack of reliable biomarkers that can determine T cell function. Bim, a member of the Bcl-2 family, was recently identified as a downstream signaling molecule
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69481bf1f08e5c77c5b1f3291d920f48
https://doi.org/10.4049/jimmunol.204.supp.165.7
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