Výsledky vyhledávání - "Jacob Hauser"

Three Patients With Chorea and Positive Voltage-Gated Potassium Channel Antibody: Is This the Link Between Hyperkinetic von Economo Disease and COVID-19?

Autor: Jacqueline Dulanto, David Chu, Pardis Saffari, Mina Abdelshahid, Prissilla Xu, Jacob Hauser, Jonathan Eskenazi, Lynnea Morm, Antonio K Liu

Publikováno v: Cureus.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57db5e24204e28b8f41042ca68247a08
https://doi.org/10.7759/cureus.35666

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Time Travel Paradoxes and Multiple Histories

Autor: Barak Shoshany, Jacob Hauser

If time travel is possible, it seems to inevitably lead to paradoxes. These include consistency paradoxes, such as the famous grandfather paradox, and bootstrap paradoxes, where something is created out of nothing. One proposed class of resolutions t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2688cd0e4a5210accbe383cb48ac9b43

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Abstract 5635: Enhanced anti-tumor lymphocyte function and frequencies measured by multichromatic flow cytometry in human CTLA-4 knock-in mice in a colorectal carcinoma model after treatment with ipilimumab

Autor: Paula L. Miliani De Marval, Fabiane Sônego, Thi Bui, Robin Ball, Ian Belle, Elizabeth Reap, Emily O’Koren, Kader Thiam, Martin Gaëlle, Jacob Hauser, Chassidy Hall, Anya Avrutskaya

Publikováno v: Cancer Research. 80:5635-5635

Targeting CTLA-4 has shown remarkable long-term benefits and thus remains a valuable approach for combating cancers of many types. A number of preclinical models have been developed over the years to evaluate the efficacy of immune checkpoint blockad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b90516becc10c001890a3366d2aabd5f
https://doi.org/10.1158/1538-7445.am2020-5635

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Abstract A015: A kinetic analysis of tumor gene expression and cellular changes following immune checkpoint inhibition in the MC38 colon carcinoma model

Autor: Patrick Fadden, Ian Belle, Kelli Davis, Katherine Krontz, David Harris, Na Li, David Hurtado, Kyle Takayama, Edgar Wood, Cristina Sokolowski, Paula L. Miliani De Marval, Thi Bui, Jacob Hauser

Publikováno v: Molecular Cancer Therapeutics. 18:A015-A015

The clinical success of immune checkpoint therapies such as PD-1, PD-L1, and CTLA-4 inhibitory antibodies has stimulated interest in a wide range of approaches to cancer immunotherapy. Development of these new modalities requires robust, well charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc9326da523aa59e22f207184d14bba0
https://doi.org/10.1158/1535-7163.targ-19-a015

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Abstract LB-063: Validation of humanized PD-1 knock-in mice as an emerging model to evaluate human specific PD-1 therapeutics

Autor: Chassidy Hall, Fabiane Sônego, Kader Thiam, Julie Chaix, Thi Bui, Gaëlle Martin, Robin Ball, Anya Avrutskaya, Paula L. Miliani De Marval, Emily O’Koren, Ian Belle, Jacob Hauser

Publikováno v: Cancer Research. 79:LB-063

Over the past decade there has been an increasing demand in the use of syngeneic models for evaluating the efficacy of checkpoint inhibition-based cancer immunotherapies. During tumor development, immune cells can became unresponsive to the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93892285f5edbfebef59d4db708ddd28
https://doi.org/10.1158/1538-7445.am2019-lb-063

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Abstract LB-060: Characterization of the immune checkpoint inhibitor response in the MC38 murine colon cancer model

Autor: Edgar Wood, Cristina Sokolowski, Thi Bui, Kyle Takayama, David Hurtado, Ian Belle, Na Li, Patrick Fadden, Kathrine Krontz, Kelli Davis, Jacob Hauser

Publikováno v: Cancer Research. 79:LB-060

Immune focused interventions remain a high priority for many drug discovery efforts, spurred on by the success of immune checkpoint therapies such as anti-PD-1, anti-PD-L1, and anti-CTLA-4 inhibitory antibodies. Preclinical efficacy assessments of no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dde10b6347cef82b340e223cb355217c
https://doi.org/10.1158/1538-7445.am2019-lb-060

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Abstract C110: Evaluation of immune cell populations in checkpoint inhibitor responsive syngeneic models

Autor: Jacob Hauser, Marcio Lasaro, Aidan Synnott, Robert J. Mullin, Sheri Barnes

Publikováno v: Molecular Cancer Therapeutics. 14:C110-C110

Given the increasing success of cancer immunotherapies, we recognized a growing need for well-characterized preclinical models to enable drug discovery efforts. Syngeneic mouse tumor models offer advantages over conventional xenograft models for immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f025982a9f9832a2aa7b91d9c0bc140
https://doi.org/10.1158/1535-7163.targ-15-c110

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Abstract 3362: Systematic evaluation of immune checkpoint inhibitors

Autor: Jacob Hauser, Tracy Brainard, Aidan Synnott, Sheri Barnes, Daniel L. Small, Robert J. Mullin, Paula L. Miliani De Marval

Publikováno v: Cancer Research. 75:3362-3362

With the increasing success and subsequent interest in tumor immunology, we recognized a growing need for well-characterized preclinical models. While the literature contains many different experimental models, the available data includes a variety o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd55771a0fcea603e76bcf580ce43b47
https://doi.org/10.1158/1538-7445.am2015-3362

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