Expression of gemcitabine metabolizing enzymes and stromal components reveal complexities of preclinical pancreatic cancer models for therapeutic testing

Autor: Lisa Knoll, Jacob Hamm, Philipp Stroebel, Todorovic Jovan, Robert Goetze, Shiv Singh, Elisabeth Hessmann, Volker Ellenrieder, Christoph Ammer-Herrmenau, Albrecht Neesse

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 53, Iss , Pp 101002- (2024)

Background: Pancreatic ductal adenocarcinoma (PDAC) poorly responds to antineoplastic agents. Discrepancies between preclinical success and clinical failure of compounds has been a continuous challenge and major obstacle in PDAC research. Aim: To inv

Externí odkaz: https://doaj.org/article/8b727644519844318e28a28330fb7aa9

Nutritional Targeting of the Microbiome as Potential Therapy for Malnutrition and Chronic Inflammation

Autor: Lena Schröder, Sina Kaiser, Burkhardt Flemer, Jacob Hamm, Finn Hinrichsen, Dora Bordoni, Philip Rosenstiel, Felix Sommer

Publikováno v: Nutrients, Vol 12, Iss 10, p 3032 (2020)

Homeostatic interactions with the microbiome are central for a healthy human physiology and nutrition is the main driving force shaping the microbiome. In the past decade, a wealth of preclinical studies mainly using gnotobiotic animal models demonst

Externí odkaz: https://doaj.org/article/7d2dbe91bc084b41a12369b34c4f606e

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

Autor: Neha Mishra, Magdalena Westermann, Nina Sommer, Philip Rosenstiel, Fredrik Bäckhed, Dora Bordoni, Marijana Basic, Christoph Kaleta, Johannes Zimmermann, Lena Schröder, Felix Sommer, Kenneth Klischies, Stefan Krautwald, Georgios Marinos, Simon Imm, Ruth A. Schmitz, Bärbel Stecher, Kensuke Shima, Jan Rupp, Jacob Hamm, Valentina Tremaroli, Finn Hinrichsen, Robert Häsler, Philippe Schmitt-Kopplin, Alesia Walker, Andrea J. Wolf, Antonella Fazio, Daniela Prasse, Sina Kaiser, Georg Laue

Publikováno v: Cell Metab. 33, 2355-2366.e8 (2021)
Hinrichsen, F, Hamm, J, Westermann, M, Schröder, L, Shima, K, Mishra, N, Walker, A, Sommer, N, Klischies, K, Prasse, D, Zimmermann, J, Kaiser, S, Bordoni, D, Fazio, A, Marinos, G, Laue, G, Imm, S, Tremaroli, V, Basic, M, Häsler, R, Schmitz, R A, Krautwald, S, Wolf, A, Stecher, B, Schmitt-Kopplin, P, Kaleta, C, Rupp, J, Bäckhed, F, Rosenstiel, P & Sommer, F 2021, ' Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis ', Cell Metabolism, vol. 33, no. 12, pp. 2355-2366.e8 . https://doi.org/10.1016/j.cmet.2021.11.004

Hexokinases (HK) catalyze the first step of glycolysis limiting its pace. HK2 is highly expressed in gut epithelium, contributes to immune responses, and is upregulated during inflammation. We examined the microbial regulation of HK2 and its impact o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ff874f57137415da69016c677d9213
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63735

Nutritional Targeting of the Microbiome as Potential Therapy for Malnutrition and Chronic Inflammation

Autor: Jacob Hamm, Felix Sommer, Sina Kaiser, Lena Schröder, Dora Bordoni, Philip Rosenstiel, Burkhardt Flemer, Finn Hinrichsen

Publikováno v: Nutrients
Nutrients, Vol 12, Iss 3032, p 3032 (2020)

Homeostatic interactions with the microbiome are central for a healthy human physiology and nutrition is the main driving force shaping the microbiome. In the past decade, a wealth of preclinical studies mainly using gnotobiotic animal models demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8634be9ed0d7abd8fc083905df6eeca
http://europepmc.org/articles/PMC7601849

Mikrobielle Regulation von Hexokinase 2 koordiniert mitochondrialen Metabolismus und Zelltod bei akuter Colitis

Autor: Kenneth Klischies, Bärbel Stecher, Valentina Tremaroli, Nina Sommer, Fredrik Bäckhed, M Basic, Daniela Prasse, Lena Schröder, P Rosenstiel, Kensuke Shima, R Schmitz-Streit, Jacob Hamm, Jan Rupp, Felix Sommer, Neha Mishra, Robert Häsler, Finn Hinrichsen

Publikováno v: DGVS Digital: BEST OF DGVS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90b2c451d0006f6973867015404db65c
https://doi.org/10.1055/s-0040-1716123