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pro vyhledávání: '"Jacob H. Wilmot"'
Acute Disruption of the Dorsal Hippocampus Impairs the Encoding and Retrieval of Trace Fear Memories
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
A major function of the hippocampus is to link discontiguous events in memory. This process can be studied in animals using Pavlovian trace conditioning, a procedure where the conditional stimulus (CS) and unconditional stimulus (US) are separated in
Externí odkaz:
https://doaj.org/article/08ef7dd3f94a4924a832f66517b7a2af
Autor:
Jacob H Wilmot, Cassiano RAF Diniz, Ana P Crestani, Kyle R Puhger, Jacob Roshgadol, Lin Tian, Brian Joseph Wiltgen
Publikováno v:
eLife, Vol 12 (2024)
Locus coeruleus (LC) projections to the hippocampus play a critical role in learning and memory. However, the precise timing of LC-hippocampus communication during learning and which LC-derived neurotransmitters are important for memory formation in
Externí odkaz:
https://doaj.org/article/6f2c6ee39f484ce0bb327e24868fdbe4
In the current study, we used fiber photometry and optogenetics to make temporally precise observations and manipulations of locus coeruleus (LC) activity during learning in a trace fear conditioning task. Although the LC is typically thought to modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aca0fda061fecea7186f77764b0a9271
https://doi.org/10.1101/2022.10.17.512590
https://doi.org/10.1101/2022.10.17.512590
Autor:
Yusuke Teratani-Ota, Sonya E. Nemes, Jamie N. Krueger, Jacob H. Wilmot, Ana Paula Crestani, Kyle R. Puhger, Brian J. Wiltgen, Marrisa M. Lafreniere
Publikováno v:
Neurobiol Learn Mem
The hippocampus plays an essential role in the formation and retrieval of episodic memories in humans and contextual memories in animals. However, amnesia is not always observed when this structure is compromised. To determine why this is the case, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13eae5fd6c7e6d5a69681e9a6df2cef3
https://escholarship.org/uc/item/9p44c7dd
https://escholarship.org/uc/item/9p44c7dd
Autor:
Kyle R. Puhger, Brian J. Wiltgen, Yusuke Teratani-Ota, Sonya E. Nemes, Jamie N. Krueger, Jacob H. Wilmot, Lafreniere M
The current study determined if inactivation of the dorsal hippocampus impairs the retrieval of newly formed context fear memories. This region was silencing by activating inhibitory neurons or by hyperpolarizing pyramidal cells directly. When inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bd1dcde8c0674b2961da350ee3e018
https://doi.org/10.1101/843342
https://doi.org/10.1101/843342