Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jacob H. Levine"'
Autor:
Jennifer A. Wargo, Alexandria P. Cogdill, Alexandre Reuben, James J. Mancuso, Spencer C. Wei, Dana Pe'er, James P. Allison, Jacob H. Levine, Nana Ama A.S. Anang, Roshan Sharma, Miles C. Andrews
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immune checkpoint blockade therapy has become a critical pillar of cancer therapy. Here, we characterize the cellular mechanisms of monotherapy and combination anti–cytotoxic T lymphocyte antigen-4 plus anti–programmed cell death-1 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b9e1b025d70a2deca5de5d0c37d766
https://pubmed.ncbi.nlm.nih.gov/31636208
https://pubmed.ncbi.nlm.nih.gov/31636208
Publikováno v:
Nature biotechnology
Single-cell RNA sequencing studies of differentiating systems have raised fundamental questions regarding the discrete versus continuous nature of both differentiation and cell fate. Here we present Palantir, an algorithm that models trajectories of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df561abd26d5c56eb74ead88576c09af
https://pubmed.ncbi.nlm.nih.gov/31534198
https://pubmed.ncbi.nlm.nih.gov/31534198
Recent studies using single cell RNA-seq (scRNA-seq) data derived from differentiating systems have raised fundamental questions regarding the discrete vs continuous nature of both differentiation and cell fate. Here we present Palantir, an algorithm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97c5b4a63a698f4f96be8e4931df082
https://doi.org/10.1101/385328
https://doi.org/10.1101/385328
Autor:
Jing Wang, Nana Ama A.S. Anang, James J. Mancuso, Dana Pe'er, Padmanee Sharma, Jacob H. Levine, Spencer C. Wei, Roshan Sharma, James P. Allison, Yang Zhao, Manu Setty
Publikováno v:
Immunity. 50(4)
Summary Co-stimulation regulates T cell activation, but it remains unclear whether co-stimulatory pathways also control T cell differentiation. We used mass cytometry to profile T cells generated in the genetic absence of the negative co-stimulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2e4e66d827a98fa240f444668eb732
https://pubmed.ncbi.nlm.nih.gov/30926234
https://pubmed.ncbi.nlm.nih.gov/30926234
Autor:
Holger Moch, Bernhard Reis, Karina Silina, Maries van den Broek, Marina Bacac, Christian Beisel, Craig Gedye, Bernd Bodenmiller, Dana Pe'er, Michael A.S. Jewett, Vito R T Zanotelli, Jacob H. Levine, Stéphane Chevrier, Daniel Schulz, Carola Ries, Michael B. Stadler, Laurie Ailles
Publikováno v:
Cell, 169 (4)
Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc8ec365ce084ea55aba5bb2bfc0970
https://hdl.handle.net/20.500.11850/191799
https://hdl.handle.net/20.500.11850/191799
Autor:
Yang Zhao, Miles C. Andrews, Jennifer A. Wargo, Dana Pe'er, Alexandria P. Cogdill, Jing Wang, Jacob H. Levine, James P. Allison, Padmanee Sharma, Spencer C. Wei, Nana Ama A.S. Anang
Publikováno v:
Cell. 170(6)
Immune-checkpoint blockade is able to achieve durable responses in a subset of patients; however, we lack a satisfying comprehension of the underlying mechanisms of anti-CTLA-4- and anti-PD-1-induced tumor rejection. To address these issues, we utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82259fb066a0d672225b88500377dc6a
https://pubmed.ncbi.nlm.nih.gov/28803728
https://pubmed.ncbi.nlm.nih.gov/28803728
Publikováno v:
Nature Biotechnology. 37:1237-1237
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fc9a4d9c40e55f5a303f2ef88dc73c9
https://doi.org/10.1038/s41587-019-0282-0
https://doi.org/10.1038/s41587-019-0282-0
Autor:
Gregory E. Demas, Ellen D. Ketterson, Stefanie Frommeyer, Alex O. Mason, Timothy J. Greives, Melissa-Ann L. Scotti, Jacob H. Levine, Lance J. Kriegsfeld
Publikováno v:
Hormones and Behavior. 52:492-498
To avoid breeding during unsuitable environmental or physiological circumstances, the reproductive axis adjusts its output in response to fluctuating internal and external conditions. The ability of the reproductive system to alter its activity appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb087b01b2e35a312043e0759d4a0261
https://doi.org/10.1016/j.yhbeh.2007.07.004
https://doi.org/10.1016/j.yhbeh.2007.07.004
Publikováno v:
Cancer Research. 77:592-592
Checkpoint blockade is able to achieve durable responses in a subset of patients, however the biological variables that distinguish responders from non-responders are not well understood. Furthermore, we lack a satisfying comprehension of the underly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d03e105495ee3c94b354ced86d8f7d5
https://doi.org/10.1158/1538-7445.am2017-592
https://doi.org/10.1158/1538-7445.am2017-592
Autor:
Catherine Sanders, Mary Beth Beasley, El-ad David Amir, Benjamin Greenbaum, Hanjie Li, Andrew Leader, Andrea S. Wolf, Klaus Meinhof, Adeeb Rahman, Marissa Vignali, Raja M. Flores, Chiara Medaglia, Yonit Lavin, Romain Remark, Naama Elefant, Dana Pe'er, Camille Bigenwald, Soma Kobayashi, Ido Amit, Ryan O. Emerson, Seunghee Kim-Shulze, Jacob H. Levine, Christian Becker, Julie A. Rytlewski, Miriam Merad, Alexander Solovyov, Andrew Chow, Sacha Gnjatic, Robert Sweeney
Publikováno v:
Cell. 169:750-765.e17
Summary To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the immune landscape of early lung adenocarcinoma lesions to search for tumor-driven immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09e4dfc1fc475b7887bc63b785562ce6
https://doi.org/10.1016/j.cell.2017.04.014
https://doi.org/10.1016/j.cell.2017.04.014