Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jacob G. Vineberg"'
Publikováno v:
The Journal of Organic Chemistry. 83:2847-2857
Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo, including those that overexpress the P-glycoprotein (Pgp) efflux pump. As SB-T-1214 is not a substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b930908d2e87fd896747cf6d6c8b802d
https://doi.org/10.1021/acs.joc.7b03284
https://doi.org/10.1021/acs.joc.7b03284
Publikováno v:
Bioorganic Chemistry. 76:458-467
Theranostics will play a significant role in the next-generation chemotherapy. Two novel tumor-targeting theranostic drug conjugates, bearing imaging arms, were designed and synthesized. These theranostic conjugates consist of biotin as the tumor-tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54206653ae14025b2ce257bb7f4171f2
https://doi.org/10.1016/j.bioorg.2017.12.018
https://doi.org/10.1016/j.bioorg.2017.12.018
Publikováno v:
The Journal of organic chemistry. 83(5)
Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo, including those that overexpress the P-glycoprotein (Pgp) efflux pump. As SB-T-1214 is not a substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a00efac63269c786d0d1b89ed779502
https://pubmed.ncbi.nlm.nih.gov/29441783
https://pubmed.ncbi.nlm.nih.gov/29441783
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:2187-2194
The folate receptor (FR) has been widely recognized as an excellent target for the tumor-selective delivery of cytotoxic agents, and four folate-drug conjugates have entered clinical evaluations for the treatment of solid tumors to date. However, mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460472f87f9f960edffec5d440d3aec1
https://doi.org/10.1016/j.bmc.2015.02.057
https://doi.org/10.1016/j.bmc.2015.02.057
Publikováno v:
Journal of Medicinal Chemistry. 58:2406-2416
Novel tumor-targeting theranostic conjugates 1 and 2, bearing either a fluorine-labeled prosthetic as a potential 18F-PET radiotracer (1) or a fluorescence-probe (2) for internalization studies in vitro, were designed and synthesized. We confirmed ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6e1af256f0b3b2e5e6ef6008409dbe
https://doi.org/10.1021/jm5019115
https://doi.org/10.1021/jm5019115
Autor:
Ying-Jen Chen, Joshua D. Seitz, Edison S. Zuniga, Anushree Kamath, Jacob G. Vineberg, Iwao Ojima
Publikováno v:
Journal of Medicinal Chemistry
Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two warheads, self-immolative disulfide linkers for drug release, biotin as the tumor-targeting moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d741a776fbb7136242247dd9941d8e
https://doi.org/10.1021/jm500631u
https://doi.org/10.1021/jm500631u
Autor:
Brendan Lichtenthal, Jonathan F. Khan, Jacob G. Vineberg, Joshua D. Seitz, Longfei Wei, Chi-Feng Lin, Iwao Ojima
Novel tumor-targeting drug conjugates, BLT-F2 (1) and BLT-S-F6 (2), bearing a fluorotaxoid as the warhead, a mechanism-based self-immolative disulfide linker, and biotin as the tumor-targeting module, were designed and synthesized as 19F NMR probes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba63700ff355068d317789bc8057cc53
https://europepmc.org/articles/PMC4337250/
https://europepmc.org/articles/PMC4337250/
Publikováno v:
Bioorganicmedicinal chemistry. 22(18)
Eukaryotic cell division or cytokinesis has been a major target for anticancer drug discovery. After the huge success of paclitaxel and docetaxel, microtubule-stabilizing agents (MSAs) appear to have gained a premier status in the discovery of next-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb54c0db34e37f21aa3d9a4900f663bc
https://pubmed.ncbi.nlm.nih.gov/24680057
https://pubmed.ncbi.nlm.nih.gov/24680057
Publikováno v:
Journal of fluorine chemistry. 152
A long-standing problem of conventional chemotherapy is the lack of tumor-specific treatments. Traditional chemotherapy relies on the premise that rapidly proliferating cancer cells are more likely to be killed by a cytotoxic agent. In reality, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56bb6c5b53f27fa0da8b6117b9bc953
https://pubmed.ncbi.nlm.nih.gov/23935213
https://pubmed.ncbi.nlm.nih.gov/23935213