Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jacob G. Kirkland"'
Autor:
Eui Jung Moon, Stephano S. Mello, Caiyun G. Li, Jen-Tsan Chi, Kaushik Thakkar, Jacob G. Kirkland, Edward L. Lagory, Ik Jae Lee, Anh N. Diep, Yu Miao, Marjan Rafat, Marta Vilalta, Laura Castellini, Adam J. Krieg, Edward E. Graves, Laura D. Attardi, Amato J. Giaccia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Hypoxia plays a critical role in tumor progression including invasion and metastasis. Here, the authors screened several hypoxia inducible genes and identified the oncogenic role of MAFF in breast cancer metastasis and that it activates IL11/STAT3 pa
Externí odkaz:
https://doaj.org/article/74a0bdf041f848a69bf653962a2ec1b4
Autor:
Simon M. G. Braun, Jacob G. Kirkland, Emma J. Chory, Dylan Husmann, Joseph P. Calarco, Gerald R. Crabtree
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Understanding the link between epigenetic marks and gene regulation requires the development of new tools to directly manipulate chromatin. Here the authors demonstrate a Cas9-based system to recruit chromatin remodelers to loci of interest, allowing
Externí odkaz:
https://doaj.org/article/ceb7020dd5784ed49c21a33809ac7893
Publikováno v:
Cancer Research. 82:B001-B001
Epigenetic cancers lead to tumor progression via oncogene activation, tumor suppressor silencing, cell fate transitions, and genomic instability. Approximately 50% of tumors have alterations in Chromatin regulators. One group of Chromatin regulators,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41c47e028b59db80362efa59994051f5
https://doi.org/10.1158/1538-7445.cancepi22-b001
https://doi.org/10.1158/1538-7445.cancepi22-b001
Autor:
Marta Vilalta, Adam J. Krieg, Caiyun G. Li, Eui Jung Moon, Amato J. Giaccia, Jen-Tsan Chi, Edward E. Graves, Jacob G. Kirkland, Stephano S. Mello, Anh N. Diep, Marjan Rafat, Yu Miao, Edward L. LaGory, Laura D. Attardi, Kaushik N. Thakkar, Laura Castellini, Ik Jae Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes for their effects on invasion. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b64acea8911667a49665037069c39
https://doi.org/10.1038/s41467-021-24631-6
https://doi.org/10.1038/s41467-021-24631-6
Autor:
Antonina Hafner, Gerald R. Crabtree, Christopher M. Weber, Jacob G. Kirkland, Benjamin Z. Stanton, Alistair N. Boettiger, Simon M. G. Braun
Publikováno v:
Nature Structural & Molecular Biology, Vol. 28, No 6 (2021) pp. 501-511
Nat Struct Mol Biol
Nat Struct Mol Biol
The mammalian SWI/SNF complex, or BAF complex, has a conserved and direct role in antagonizing Polycomb-mediated repression. Yet, BAF also promotes repression by Polycomb in stem cells and cancer. How BAF both antagonizes and promotes Polycomb-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d553f63fe89284877c325a5813a60c66
https://archive-ouverte.unige.ch/unige:154515
https://archive-ouverte.unige.ch/unige:154515
Autor:
Chiung-Ying Chang, Gerald R. Crabtree, Sai Gourisankar, Vincent D. D’Andrea, Emily C. Dykhuizen, Emma J. Chory, Jacob G. Kirkland
Publikováno v:
ACS Chem Biol
SWI/SNF (BAF) complexes are a diverse family of ATP-dependent chromatin remodelers produced by combinatorial assembly that are mutated in and thought to contribute to 20% of human cancers and a large number of neurologic diseases. The gene-activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cce54bbfa736d7dcb11c9a0e0262d8
https://europepmc.org/articles/PMC8273930/
https://europepmc.org/articles/PMC8273930/
Autor:
Christopher M. Weber, Jacob G. Kirkland, Alistair N. Boettiger, Simon M. G. Braun, Antonina Hafner, Gerald R. Crabtree, Benjamin Z. Stanton
The mammalian SWI/SNF, or BAF complex, has a conserved and direct role in antagonizing polycomb-mediated repression. Yet, BAF appears to also promote repression by polycomb in stem cells and cancer. How BAF both antagonizes and promotes polycomb-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6fd1e607a213f67b87c830bce49e208
https://doi.org/10.1101/2020.01.29.925586
https://doi.org/10.1101/2020.01.29.925586
Autor:
Giulia J Ruben, Jacob G Kirkland, Tracy MacDonough, Miao Chen, Rudra N Dubey, Marc R Gartenberg, Rohinton T Kamakaka
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21923 (2011)
The organization of chromatin domains in the nucleus is an important factor in gene regulation. In eukaryotic nuclei, transcriptionally silenced chromatin clusters at the nuclear periphery while transcriptionally poised chromatin resides in the nucle
Externí odkaz:
https://doaj.org/article/db3f8eae61094cfb9be1f4fac025bc1d
Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers
Autor:
Katerina Cermakova, Benjamin Z. Stanton, Keji Zhao, Chiung-Ying Chang, H. Courtney Hodges, Gerald R. Crabtree, Jacob G. Kirkland, Vaclav Veverka, Erik L. Miller, Wai Lim Ku
Publikováno v:
Nature Structural & Molecular Biology. 25:61-72
Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. Unfortunately, the effects of SMARCA4 missense mutations have remained uncertain. Here we show that SMARCA4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55a788947426a773f199e53f4d7330b6
https://doi.org/10.1038/s41594-017-0007-3
https://doi.org/10.1038/s41594-017-0007-3
Autor:
Gerald R. Crabtree, Jacob G. Kirkland, Vincent D. D’Andrea, Emma J. Chory, Sai Gourinsankar, Emily C. Dykhuizen, Chiung-Ying Chang
SWI/SNF (BAF) complexes are a diverse family of ATP-dependent chromatin remodelers produced by combinatorial assembly that are mutated in and thought to contribute to 20% of human cancers and a large number of neurologic diseases. The gene-activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea9399966964208ceebf5f5ed31b614