Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jacob G. Henderson"'
Publikováno v:
J Immunol
Von Hippel–Lindau (VHL) is an E3 ubiquitin ligase that targets proteins, including HIF-1α, for proteasomal degradation. VHL and HIF regulate the balance between glycolysis and oxidative phosphorylation, which is critical in highly dynamic T cells.
Publikováno v:
The Journal of Immunology. 197:2646-2652
IL-22 is expressed by activated lymphocytes and is important in modulation of tissue responses during inflammation. The cytokine induces proliferative and antiapoptotic pathways in epithelial cells allowing enhanced cell survival. This can have posit
Publikováno v:
Immunity. 42:471-483
SummarySelf-reactive T cells can escape thymic deletion and therefore some of these potentially autoaggressive T cells need to convert into regulatory T (Treg) cells to help control responses against self. However, it remains unknown how peripheral s
Autor:
Jacob G. Henderson, Daniela Galimberti, Lawrence Chan, Laura Piccio, Robert Mikesell, Viviana Cremasco, Michael J. Ramsbottom, Wesley Haynes, Anne H. Cross, Jiyoon Ryu, Chyi-Song Hsieh, Claudia Cantoni, Daniel Hawiger, Lily Q. Dong
Publikováno v:
European Journal of Immunology. 43:2089-2100
Multiple sclerosis (MS) is a presumed autoimmune disease directed against central nervous system (CNS) myelin, in which diet and obesity are implicated as risk factors. Immune responses can be influenced by molecules produced by fat cells, called adi
Autor:
Adeleye Opejin, Jacob G. Henderson, Jonathan A. Epstein, Andrew Jones, Cindy Gross, Rajan Jain, Daniel Hawiger, Richard A. Flavell
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 195(4)
Dendritic cells (DCs) can induce peripheral immune tolerance that prevents autoimmune responses. Ag presentation by peripheral DCs under steady-state conditions leads to a conversion of some peripheral CD4+ T cells into regulatory T cells (Tregs) tha
Autor:
Jacob G. Henderson, Daniel Hawiger
Publikováno v:
Oncotarget
The immune system must carefully regulate the balance between immunity and tolerance in order to prevent disease. Mechanisms of tolerance include crucial functions of thymically developed regulatory T (tTreg) cells as well as peripheral regulatory T