Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jacob Fulp"'
Autor:
Chunqing Guo, Xiang-Yang Wang, Xia Li, Stefano Toldo, Liu He, Jacob Fulp, Ashley Boice, Dong Sun, Andrew Rolfe, Antonio Abbate, Shijun Zhang, Yuqi Jiang
Publikováno v:
Journal of Medicinal Chemistry. 61:5412-5423
NLRP3 inflammasome plays critical roles in a variety of human diseases and represents a promising drug target. In this study, we established the in vivo functional activities of JC124, a previously identified NLRP3 inflamma-some inhibitor from our gr
Autor:
Yuqi Jiang, Jingde Wu, Jeremy E. Chojnacki, Xia Li, Shijun Zhang, Xiang-Yang Wang, Chunqing Guo, Jacob Fulp
Publikováno v:
ACS Chemical Neuroscience. 8:2194-2201
In our efforts to develop novel small-molecule inhibitors for the NOD-like receptor family pyrin-domain-containing 3 (NLRP3) inflammasome as potential disease-modifying agents to treat neurological disorders including multiple sclerosis (MS), a hydro
Autor:
Shijun Zhang, Jacob Fulp, Xiongwei Zhu, Jeremy E. Chojnacki, Jun Yin, Fanpeng Zhao, William L. Klein
Publikováno v:
Molecular Neurobiology. 55:1977-1987
The activation of the NLRP3 inflammasome signaling pathway plays an important role in the neuroinflammation in Alzheimer’s disease (AD). In this study, we investigated the effects of JC-124, a rationally designed NLRP3 inflammasome inhibitor, on AD
Publikováno v:
Alzheimer's & Dementia. 12