Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jacob Folz"'
Autor:
Jun Ding, Jian Ji, Zachary Rabow, Tong Shen, Jacob Folz, Christopher R. Brydges, Sili Fan, Xinchen Lu, Sajjan Mehta, Megan R. Showalter, Ying Zhang, Renee Araiza, Lynette R. Bower, K. C. Kent Lloyd, Oliver Fiehn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Metabolites play an important role in physiology, yet the complexity of the metabolome and its interaction with disease and aging is poorly understood. Here the authors present a comprehensive atlas of the mouse brain metabolome and how it changes du
Externí odkaz:
https://doaj.org/article/a2f3452ce44b41c2919934ac9e218480
Autor:
Drago Haas, Antje M. Thamm, Jiayi Sun, Lili Huang, Lijie Sun, Guillaume A. W. Beaudoin, Kim S. Wise, Claudia Lerma-Ortiz, Steven D. Bruner, Marian Breuer, Zaida Luthey-Schulten, Jiusheng Lin, Mark A. Wilson, Greg Brown, Alexander F. Yakunin, Inna Kurilyak, Jacob Folz, Oliver Fiehn, John I. Glass, Andrew D. Hanson, Christopher S. Henry, Valérie de Crécy-Lagard
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Analysis of the genes retained in the minimized Mycoplasma JCVI-Syn3A genome established that systems that repair or preempt metabolite damage are essential to life. Several genes known to have such functions were identified and experimental
Externí odkaz:
https://doaj.org/article/71126318982049979973bef57993dd2a
Autor:
Dari Shalon, Rebecca Neal Culver, Jessica A. Grembi, Jacob Folz, Peter V. Treit, Handuo Shi, Florian A. Rosenberger, Les Dethlefsen, Xiandong Meng, Eitan Yaffe, Andrés Aranda-Díaz, Philipp E. Geyer, Johannes B. Mueller-Reif, Sean Spencer, Andrew D. Patterson, George Triadafilopoulos, Susan P. Holmes, Matthias Mann, Oliver Fiehn, David A. Relman, Kerwyn Casey Huang
Publikováno v:
Nature, vol 617, iss 7961
The spatiotemporal structure of the human microbiome1,2, proteome3 and metabolome4,5 reflects and determines regional intestinal physiology and may have implications for disease6. Yet, little is known about the distribution of microorganisms, their e
Autor:
Guillaume A. W. Beaudoin, Qiang Li, Jacob Folz, Oliver Fiehn, Justin L. Goodsell, Alexander Angerhofer, Steven D. Bruner, Andrew D. Hanson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
5-Deoxyribose is formed from 5′-deoxyadenosine, a toxic byproduct of radical S-adenosylmethionine enzymes. Here, the authors identify and biochemically characterize a bacterial salvage pathway for 5-deoxyribose, consisting of three enzymes, and sol
Externí odkaz:
https://doaj.org/article/8f102546de1241ed9baef7187af4175b
Autor:
Jacob Folz, Rebecca Neal Culver, Juan Montes Morales, Jessica Grembi, George Triadafilopoulos, David A. Relman, Kerwyn Casey Huang, Dari Shalon, Oliver Fiehn
Publikováno v:
Nature metabolism, vol 5, iss 5
Most processing of the human diet occurs in the small intestine. Metabolites in the small intestine originate from host secretions, plus the ingested exposome1 and microbial transformations. Here we probe the spatiotemporal variation of upper intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becbfaead4a37936a8fda43b29f18c32
https://escholarship.org/uc/item/8kq2w6q8
https://escholarship.org/uc/item/8kq2w6q8
Autor:
Jacob Folz, Rebecca Culver, Juan Morales, Jessica Grembi, George Triadafilopoulos, David Relman, KC Huang, Dari Shalon, Oliver Fiehn
Most utilization of human diets occurs in the small intestine, which remains largely unstudied. Here, we used a novel non-invasive, ingestible sampling device to probe the spatiotemporal variation of upper intestinal luminal contents during routine d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2de418187a304946dae710030e0d22f5
https://doi.org/10.21203/rs.3.rs-2099937/v1
https://doi.org/10.21203/rs.3.rs-2099937/v1
Publikováno v:
Food & Function. 12:9405-9415
The human small intestine remains an elusive organ to study due to the difficulty of retrieving samples in a non-invasive manner. Stool samples as a surrogate do not reflect events in the upper gut intestinal tract. As proof of concept, this study in
Autor:
Dari Shalon, Rebecca Neal Culver, Jessica A. Grembi, Jacob Folz, Peter Treit, Les Dethlefsen, Xiandong Meng, Eitan Yaffe, Sean Spencer, Handuo Shi, Andrés Aranda-Díaz, Andrew D. Patterson, George Triadafilopoulos, Susan P. Holmes, Matthias Mann, Oliver Fiehn, David A. Relman, Kerwyn Casey Huang
The spatiotemporal structure of the human microbiome and metabolome reflects and determines regional intestinal physiology and may have implications for disease. Yet, we know little about the distribution of microbes and their products in the gut bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cdc51242eb8fd2aea66180ee08fa3f4
https://doi.org/10.1101/2022.01.19.476920
https://doi.org/10.1101/2022.01.19.476920
Autor:
Steven D. Bruner, Jacob Folz, John I. Glass, I. Inna Kurilyak, D. Haas, Christopher S. Henry, Oliver Fiehn, Alexander F. Yakunin, Jiusheng Lin, Andrew D. Hanson, Kim S. Wise, J. Sun, V. de Crecy-Lagard, Marian Breuer, Antje M. K. Thamm, Zaida Luthey-Schulten, Mark A. Wilson, Claudia Lerma-Ortiz, Lili Huang, Greg Brown, Lijie Sun, Guillaume A.W. Beaudoin
Analysis of the genes retained in the minimized Mycoplasma JCVI-Syn3A genome established that systems that repair or preempt metabolite damage are essential to life. Several genes with known metabolite damage repair or preemption functions were ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1609a03e8cc1fb162cbefb85faee77e3
https://doi.org/10.1101/2021.12.01.470718
https://doi.org/10.1101/2021.12.01.470718
Autor:
Xinchen Lu, Jun Ding, Ying Zhang, Lynette Bower, Oliver Fiehn, Sili Fan, Jian Ji, Christopher R. Brydges, Tong Shen, Megan R. Showalter, Renee S. Araiza, Kevin C K Lloyd, Jacob Folz, Zachary Rabow, Sajjan S. Mehta
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of the brain metabolome and its changes during diseases or aging remain poorly understood. Here, we generate a metabolome atlas of the aging wildtype mouse bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc736ba1469cc0fc81d231c8cdd1d034
https://escholarship.org/uc/item/5ct1x9mh
https://escholarship.org/uc/item/5ct1x9mh