Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Jacob F. Wardman"'
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A Synthetic Gene Library Yields a Previously Unknown Glycoside Phosphorylase That Degrades and Assembles Poly-β-1,3-GlcNAc, Completing the Suite of β-Linked GlcNAc Polysaccharides
Autor: Spencer S. Macdonald, Jose H. Pereira, Feng Liu, Gregor Tegl, Andy DeGiovanni, Jacob F. Wardman, Samuel Deutsch, Yasuo Yoshikuni, Paul D. Adams, Stephen G. Withers
Publikováno v: ACS central science, vol 8, iss 4
The considerable utility of glycoside phosphorylases (GPs) has led to substantial efforts over the past two decades to expand the breadth of known GP activities. Driven largely by the increase of available genomic DNA sequence data, the gap between t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a371980bbe30d65b13f87de086838c
https://doi.org/10.1021/acscentsci.1c01570
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4
Discovery and Development of Promiscuous O-Glycan Hydrolases for Removal of Intact Sialyl T-Antigen
Autor: Lyann Sim, Peter Rahfeld, Connor Morgan-Lang, Stephen G. Withers, Jacob F. Wardman, Feng Liu, Steven J. Hallam
Publikováno v: ACS Chemical Biology. 16:2004-2015
Mucin-type O-glycosylation (O-glycosylation) is a common post-translational modification that confers distinct biophysical properties to proteins and plays crucial roles in intercellular signaling. Yet, despite the importance of O-glycans, relatively
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c113875836e2572dd6dd8b7cc81cebb
https://doi.org/10.1021/acschembio.1c00316
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5
Synthesis and evaluation of sensitive coumarin-based fluorogenic substrates for discovery of α-N-acetyl galactosaminidases through droplet-based screening
Autor: Seyed A. Nasseri, Hong-Ming Chen, Stephen G. Withers, Jacob F. Wardman, Peter Rahfeld, Maurits Kohsiek
Publikováno v: Organic & Biomolecular Chemistry. 19:789-793
As part of a search for a substrate for droplet-based microfluidic screening assay of α-N-acetylgalactosaminidases, spectral and physical characteristics of a series of coumarin derivatives were measured. From among these a new coumarin-based fluoro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436f2e1e31fae4eaffffdeb5c1f0caec
https://doi.org/10.1039/d0ob02484h
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7
Biosynthesis of the psychotropic plant diterpene salvinorin A: Discovery and characterization of the Salvia divinorum clerodienyl diphosphate synthase
Autor: Rod Mitchell, Dae-Kyun Ro, Kyle A. Pelot, Moonhyuk Kwon, Angela Chiang, Philipp Zerbe, Jacob F. Wardman, Lynne M. Hagelthorn, Jörg Bohlmann
Publikováno v: The Plant Journal. 89:885-897
Summary Salvia divinorum commonly known as diviner's sage, is an ethnomedicinal plant of the mint family (Lamiaceae). S. divinorum is rich in clerodane-type diterpenoids, which accumulate predominantly in leaf glandular trichomes. The main bioactive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6722567e519f46501b51eb4d2459e422
https://doi.org/10.1111/tpj.13427
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8
Prospecting for microbial α-N-acetylgalactosaminidases yields a new class of GH31 O-glycanase
Autor: Stephen G. Withers, Connor Morgan-Lang, Jacob F. Wardman, Kevin Mehr, Steven J. Hallam, Hong-Ming Chen, Drew Huff, Peter Rahfeld
Publikováno v: J Biol Chem
α-Linked GalNAc (α-GalNAc) is most notably found at the nonreducing terminus of the blood type-determining A-antigen and as the initial point of attachment to the peptide backbone in mucin-type O-glycans. However, despite their ubiquity in saccharo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4ffa88720220f506b757a4f8da1452
https://europepmc.org/articles/PMC6827296/
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