Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jacob F. Jeppesen"'
Autor:
Alessandra Dall’Agnese, Jesse M. Platt, Ming M. Zheng, Max Friesen, Giuseppe Dall’Agnese, Alyssa M. Blaise, Jessica B. Spinelli, Jonathan E. Henninger, Erin N. Tevonian, Nancy M. Hannett, Charalampos Lazaris, Hannah K. Drescher, Lea M. Bartsch, Henry R. Kilgore, Rudolf Jaenisch, Linda G. Griffith, Ibrahim I. Cisse, Jacob F. Jeppesen, Tong I. Lee, Richard A. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The authors find that the insulin receptor forms dynamic clusters during insulin signaling and that these clusters become dysfunctional in insulin resistance. This dysfunction is partially rescued by metformin, a drug used to treat type 2 diabetes.
Externí odkaz:
https://doaj.org/article/b6a27a393d354ad08dc4d2e2cdc0f034
Autor:
Christian T. Madsen, Jan C. Refsgaard, Felix G. Teufel, Sonny K. Kjærulff, Zhe Wang, Guangjun Meng, Carsten Jessen, Petteri Heljo, Qunfeng Jiang, Xin Zhao, Bo Wu, Xueping Zhou, Yang Tang, Jacob F. Jeppesen, Christian D. Kelstrup, Stephen T. Buckley, Søren Tullin, Jan Nygaard-Jensen, Xiaoli Chen, Fang Zhang, Jesper V. Olsen, Dan Han, Mads Grønborg, Ulrik de Lichtenberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Bioactive peptides regulate many physiological functions but progress in discovering them has been slow. Here, the authors use a machine learning framework to predict mammalian peptide candidates from the global and local structure of large-scale tis
Externí odkaz:
https://doaj.org/article/a22e4dc1d677467ea63d53214d5a93bc
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 6, Pp 100097- (2020)
Summary: Autoimmune destruction of pancreatic β cells underlies type 1 diabetes (T1D). To understand T cell-mediated immune effects on human pancreatic β cells, we combine β cell-specific expression of a model antigen, CD19, and anti-CD19 chimeric
Externí odkaz:
https://doaj.org/article/10033a72f7df4b27ad3425420dd40d59
Autor:
Andreas Mæchel Fritzen, Joan Domingo-Espín, Anne-Marie Lundsgaard, Maximilian Kleinert, Ida Israelsen, Christian S. Carl, Trine S. Nicolaisen, Rasmus Kjøbsted, Jacob F. Jeppesen, Jørgen F.P. Wojtaszewski, Jens O. Lagerstedt, Bente Kiens
Publikováno v:
Molecular Metabolism, Vol 35, Iss , Pp - (2020)
Objective: Acute administration of the main protein component of high-density lipoprotein, apolipoprotein A-I (ApoA-1), improves glucose uptake in skeletal muscle. The molecular mechanisms mediating this are not known, but in muscle cell cultures, Ap
Externí odkaz:
https://doaj.org/article/e7375ff2f5d843a68500a32a5a557945
Autor:
Max Friesen, Andrew S. Khalil, M. Inmaculada Barrasa, Jacob F. Jeppesen, David J. Mooney, Rudolf Jaenisch
Publikováno v:
Science Advances. 8
Adipocytes are key regulators of human metabolism, and their dysfunction in insulin signaling is central to metabolic diseases including type II diabetes mellitus (T2D). However, the progression of insulin resistance into T2D is still poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa81c4fd8db6281b1873a8cc5caf6e60
https://doi.org/10.1126/sciadv.abn7298
https://doi.org/10.1126/sciadv.abn7298
Publikováno v:
Diabetes. 71
An estimated 70% of individuals with type 2 diabetes also suffer from nonalcoholic fatty liver disease (NAFLD) . Insulin resistance is pathologically fundamental to both NAFLD and T2D, however the mechanisms of insulin resistance linking these comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78aea5ccd97052d2158e36d323ff5c18
https://doi.org/10.2337/db22-1344-p
https://doi.org/10.2337/db22-1344-p
Publikováno v:
Diabetes. 71
Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in metabolic diseases such as type 2 diabetes. We have found that IR is incorporated into biomolecular condensates during the response to insulin stimulation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b64880dbe3c5e9095a727146542138e7
https://doi.org/10.2337/db22-1305-p
https://doi.org/10.2337/db22-1305-p
Autor:
CHRISTIAN FLEDELIUS, HELLE IVERSEN, RIKKE S. INGVORSEN, LISBETH B. ERIKSEN, ANNA BLOIS, YVENET MONTAUBAN, RENE RIJNBRAND, WEN HAN, JACOB F. JEPPESEN, DAMIEN DEMOZAY
Publikováno v:
Diabetes. 71
Insulin resistant individuals display elevated fasting and post-prandial glucose levels which are mainly driven by inadequate inhibition of gluconeogenesis (GNG) and are rarely normalized. The aim of this study was to investigate whether direct inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46368123f0ad423fe26b32e0ae16e125
https://doi.org/10.2337/db22-215-lb
https://doi.org/10.2337/db22-215-lb
Autor:
Haiting Ma, Esmée de Zwaan, Yang Eric Guo, Paloma Cejas, Prathapan Thiru, Martijn van de Bunt, Jacob F. Jeppesen, Sudeepa Syamala, Alessandra Dall’Agnese, Brian J. Abraham, Dongdong Fu, Carrie Garrett-Engele, Tony Lee, Henry W Long, Linda G. Griffith, Richard A. Young, Rudolf Jaenisch
SummaryThe capacity to generate functional hepatocytes from renewable human pluripotent stem cells (hPSCs) could address limited supplies of primary human hepatocytes. However, hepatocytes differentiated from hPSCs in vitro are functionally immature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50ac04c1c5068518e351f2d0f799eabd
https://doi.org/10.1101/2022.03.24.485641
https://doi.org/10.1101/2022.03.24.485641
Autor:
Sanaz, Gabery, Casper G, Salinas, Sarah J, Paulsen, Jonas, Ahnfelt-Rønne, Tomas, Alanentalo, Arian F, Baquero, Stephen T, Buckley, Erzsébet, Farkas, Csaba, Fekete, Klaus S, Frederiksen, Hans Christian C, Helms, Jacob F, Jeppesen, Linu M, John, Charles, Pyke, Jane, Nøhr, Tess T, Lu, Joseph, Polex-Wolf, Vincent, Prevot, Kirsten, Raun, Lotte, Simonsen, Gao, Sun, Anett, Szilvásy-Szabó, Hanni, Willenbrock, Anna, Secher, Lotte Bjerre, Knudsen, Wouter Frederik Johan, Hogendorf
Publikováno v:
JCI Insight
Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic preclinical studies suggest weight loss is mediated through GLP-1 receptors (GLP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5006d9b7db3d895b39c5ce61e76405
https://pubmed.ncbi.nlm.nih.gov/32213703
https://pubmed.ncbi.nlm.nih.gov/32213703