Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jacob Elmer"'
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 52, Iss 1, Pp 291-299 (2024)
AbstractHaemorrhagic shock is a leading cause of death worldwide. Blood transfusions can be used to treat patients suffering severe blood loss but donated red blood cells (RBCs) have several limitations that limit their availability and use. To solve
Externí odkaz:
https://doaj.org/article/0c2a076758a246d7b44358f7c8f9132f
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 43-56 (2023)
The innate immune response to cytosolic DNA is intended to protect the host from viral infections, but it can also inhibit the delivery and expression of therapeutic transgenes in gene and cell therapies. The goal of this work was to use mRNA sequenc
Externí odkaz:
https://doaj.org/article/aec02925143b4ae2ad5c9b27836c0554
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 530 (2020)
A persistent challenge for mammalian cell engineering is the undesirable epigenetic silencing of transgenes. Foreign DNA can be incorporated into closed chromatin before and after it has been integrated into a host cell’s genome. To identify elemen
Externí odkaz:
https://doaj.org/article/4235393519364ca5835f58be619a9da3
Autor:
Jacob Elmer, Andre F. Palmer
Publikováno v:
Journal of Functional Biomaterials, Vol 3, Iss 1, Pp 49-60 (2012)
Previous generations of hemoglobin (Hb)-based oxygen carriers (HBOCs) have been plagued by key biophysical limitations that result in severe side-effects once transfused in vivo, including protein instability, high heme oxidation rates, and nitric ox
Externí odkaz:
https://doaj.org/article/70c7e8399d5145ac8dca0a7ce531bae2
Autor:
Sean Dowd, Jacob Elmer
Publikováno v:
Blood Substitutes and Oxygen Biotherapeutics ISBN: 9783030959746
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebdfcdcb9b614150e3b99c980386639d
https://doi.org/10.1007/978-3-030-95975-3_26
https://doi.org/10.1007/978-3-030-95975-3_26
The innate immune response to cytosolic DNA is intended to protect the host from viral infections, but it can also inhibit the delivery and expression of therapeutic transgenes in gene and cell therapies. The goal of this work was to use mRNA-sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::764669629b67148d218bbb9762c0e451
https://doi.org/10.1101/2021.06.21.449271
https://doi.org/10.1101/2021.06.21.449271
Publikováno v:
Molecular therapy. Nucleic acids. 31
The innate immune response to cytosolic DNA is intended to protect the host from viral infections, but it can also inhibit the delivery and expression of therapeutic transgenes in gene and cell therapies. The goal of this work was to use mRNA sequenc
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(4)
Retroviral gene delivery is widely used in T cell therapies for hematological cancers. However, viral vectors are expensive to manufacture, integrate genes in semi-random patterns, and their transduction efficiency varies between patients. In this st
Retroviral gene delivery is widely used in T cell therapies for hematological cancers. However, viral vectors are expensive to manufacture, they integrate genes in semi-random patterns, and their transduction efficiency is highly variable. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a5b410b2ce8391a4dadfd4f12cab52
https://doi.org/10.22541/au.160262388.84292192/v1
https://doi.org/10.22541/au.160262388.84292192/v1