Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Jacob E. Friedman"'
Autor:
Darian T. Carroll, Allie Miller, Jennifer Fuhr, Joseph M. Elsakr, Valerie Ricciardi, Alexa N. Del Bene, Stedman Stephens, Evan Krystofiak, Sarah R. Lindsley, Melissa Kirigiti, Diana L. Takahashi, Tyler A. Dean, Stephanie R. Wesolowski, Carrie E. McCurdy, Jacob E. Friedman, Kjersti M. Aagaard, Paul Kievit, Maureen Gannon
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionUsing a non-human primate (NHP) model of maternal Western-style diet (mWSD) feeding during pregnancy and lactation, we previously reported altered offspring beta:alpha cell ratio in vivo and insulin hyper-secretion ex vivo. Mitochondria a
Externí odkaz:
https://doaj.org/article/2aefe612d931437fb2599f63ef8e7bf0
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Dong Wang, Eric M. Pietras, Rachel C. Janssen, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102849- (2024)
Summary: Studying fetal hematopoiesis is challenging as hematopoiesis transitions from the liver to bone marrow. Obtaining human samples is not possible, and small animal models may not provide sufficient biological material. Here, we present a proto
Externí odkaz:
https://doaj.org/article/1408351a7a1948bd90187a6ca66f9581
Autor:
Kameron Y. Sugino, Teri L. Hernandez, Linda A. Barbour, Jennifer M. Kofonow, Daniel N. Frank, Jacob E. Friedman
Publikováno v:
Microorganisms, Vol 12, Iss 7, p 1369 (2024)
Gestational diabetes mellitus (GDM) triggers alterations in the maternal microbiome. Alongside metabolic shifts, microbial products may impact clinical factors and influence pregnancy outcomes. We investigated maternal microbiome-metabolomic changes,
Externí odkaz:
https://doaj.org/article/262dbc8f44504158ac85d7696c10cbe7
Autor:
Kameron Y. Sugino, Rachel C. Janssen, Rachel H. McMahan, Chelsea Zimmerman, Jacob E. Friedman, Karen R. Jonscher
Publikováno v:
Nutrients, Vol 16, Iss 12, p 1808 (2024)
Maternal obesity and/or Western diet (WD) is associated with an increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in offspring, driven, in part, by the dysregulation of the early life microbiome. Here, using a mouse m
Externí odkaz:
https://doaj.org/article/6e599e279493473a97ecfd13c99e0451
Autor:
Benjamin N. Nelson, Jacob E. Friedman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5951 (2024)
Maternal obesity and over/undernutrition can have a long-lasting impact on offspring health during critical periods in the first 1000 days of life. Children born to mothers with obesity have reduced immune responses to stimuli which increase suscepti
Externí odkaz:
https://doaj.org/article/4a369c8c41b14a5dba2fdef8a627e43e
Autor:
David Matye, Sumedha Gunewardena, Jianglei Chen, Huaiwen Wang, Yifeng Wang, Mohammad Nazmul Hasan, Lijie Gu, Yung Dai Clayton, Yanhong Du, Cheng Chen, Jacob E. Friedman, Shelly C. Lu, Wen-Xing Ding, Tiangang Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Matye el al. show that coenzyme-A and glutathione deficiency in NAFLD limits fatty acid oxidation and antioxidant defence capacity. The nutrient sensing transcription factor EB induces autophagy–lysosome proteolysis and methionine cycle-transsulfur
Externí odkaz:
https://doaj.org/article/52ea7c8d29184987a1cfd046310b0ed5
Autor:
Li Zhang, Karen R. Jonscher, Zuyuan Zhang, Yi Xiong, Ryan S. Mueller, Jacob E. Friedman, Chongle Pan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here, by characterizing gut metagenomes of at-risk children in the TEDDY project, the authors associate onset of autoimmunity leading to Type-1 diabetes with certain sets of microorganisms in the gut microbiota, and identify metabolic capabilities en
Externí odkaz:
https://doaj.org/article/719d359e9c3c4a7dbc8bcabadc2939a3
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Taylor K. Soderborg, Rachel C. Janssen, Diana L. Takahashi, Tyler A. Dean, Oleg Varlamov, Jon D. Hennebold, Maureen Gannon, Kjersti M. Aagaard, Carrie E. McCurdy, Paul Kievit, Bryan C. Bergman, Kenneth L. Jones, Eric M. Pietras, Stephanie R. Wesolowski, Jacob E. Friedman
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112393- (2023)
Summary: Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal offspring. This constitutes a major public health concern due to increasing prevalence of these diseases, yet mechanisms remain unclear. Here, using nonhum
Externí odkaz:
https://doaj.org/article/61f8abfb16c94221819b0fcca9d1aea3
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Rachel C. Janssen, Mark A. Lovell, Deborah A. Schady, Claire Levek, Kenneth L. Jones, Angelo D’Alessandro, Paul Kievit, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0014-e0014 (2023)
Pediatric NAFLD has distinct and variable pathology, yet causation remains unclear. We have shown that maternal Western-style diet (mWSD) compared with maternal chow diet (CD) consumption in nonhuman primates produces hepatic injury and steatosis in
Externí odkaz:
https://doaj.org/article/6bcad75da676422bbcbdb90a6e13d609
Autor:
Rohan Varshney, Snehasis Das, G. Devon Trahan, Jacob W. Farriester, Gregory P. Mullen, Gertrude Kyere-Davies, David M. Presby, Julie A. Houck, Patricia G. Webb, Monika Dzieciatkowska, Kenneth L. Jones, Matthew S. Rodeheffer, Jacob E. Friedman, Paul S. MacLean, Michael C. Rudolph
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105750- (2023)
Summary: Establishing metabolic programming begins during fetal and postnatal development, and early-life lipid exposures play a critical role during neonatal adipogenesis. We define how neonatal consumption of a low omega-6 to −3 fatty acid ratio
Externí odkaz:
https://doaj.org/article/9bad93f7d4e444bcbb9d60d4a40fb54f