Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jacob E. Choby"'
Autor:
David A. Hufnagel, Jacob E. Choby, Samantha Hao, Anders F. Johnson, Eileen M. Burd, Charles Langelier, David S. Weiss
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
To inhibit bacterial transmission and infection, health care facilities use bactericidal metal coatings to prevent colonization of surfaces and implanted devices. In these environments, antibiotics are commonly used, but their effect on metal resista
Externí odkaz:
https://doaj.org/article/0107dd152e7f461c8f97e26587ceabb1
Autor:
Jacob E. Choby, Eric P. Skaar
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT The virulence of the human pathogen Staphylococcus aureus is supported by many heme-dependent proteins, including key enzymes of cellular respiration. Therefore, synthesis of heme is a critical component of staphylococcal physiology. S. aure
Externí odkaz:
https://doaj.org/article/8aa69ac3e0ab46e28942269a50cbe52e
Autor:
Caroline M. Grunenwald, Jacob E. Choby, Lillian J. Juttukonda, William N. Beavers, Andy Weiss, Victor J. Torres, Eric P. Skaar
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT Manganese (Mn) is an essential micronutrient critical for the pathogenesis of Staphylococcus aureus, a significant cause of human morbidity and mortality. Paradoxically, excess Mn is toxic; therefore, maintenance of intracellular Mn homeosta
Externí odkaz:
https://doaj.org/article/60f1432fa64645f791d315ca384e153c
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Metals are a limiting resource for pathogenic bacteria and must be scavenged from host proteins. Hemoglobin provides the most abundant source of iron in the human body and is required by several pathogens to cause invasive disease. However,
Externí odkaz:
https://doaj.org/article/1ffa2eb9911b43c3946feb116ac169b2
Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis
Autor:
Jacob E. Choby, Caroline M. Grunenwald, Arianna I. Celis, Svetlana Y. Gerdes, Jennifer L. DuBois, Eric P. Skaar
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT Staphylococcus aureus is responsible for a significant amount of devastating disease. Its ability to colonize the host and cause infection is supported by a variety of proteins that are dependent on the cofactor heme. Heme is a porphyrin use
Externí odkaz:
https://doaj.org/article/405059706deb49fc97647c9d061a40c4
Novel antibiotics are threatened by rapid emergence of resistance. Heteroresistance (HR) is a form of resistance where a phenotypically unstable and often undetected minority resistant subpopulation co-exists with a susceptible population. We observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1e07dfe7cd061207100ae671511adbf
https://doi.org/10.1101/2022.06.07.494873
https://doi.org/10.1101/2022.06.07.494873
Publikováno v:
Biochemistry
The pathway for assembling heme ends with a unique set of enzymes in Gram-positive bacteria. Substrates for these reactions include coproporphyrin III, Fe(II), and H(2)O(2), which are highly reactive and toxic. Because these bacteria lack membranous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1eaf16624b42daeff0a461ed05b32c
https://doi.org/10.1021/acs.biochem.9b00140
https://doi.org/10.1021/acs.biochem.9b00140
Publikováno v:
The Lancet Microbe, Vol 2, Iss 12, Pp e648-e649 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d01480a78fbb23b56d5d407690b90ad
https://doi.org/10.1016/s2666-5247(21)00271-8
https://doi.org/10.1016/s2666-5247(21)00271-8
Autor:
Laura A Mike, Jacob E Choby, Paul R Brinkman, Lorenzo Q Olive, Brendan F Dutter, Samuel J Ivan, Christopher M Gibbs, Gary A Sulikowski, Devin L Stauff, Eric P Skaar
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1004044 (2014)
Two-component signaling systems (TCSs) are one of the mechanisms that bacteria employ to sense and adapt to changes in the environment. A prototypical TCS functions as a phosphorelay from a membrane-bound sensor histidine kinase (HK) to a cytoplasmic
Externí odkaz:
https://doaj.org/article/36c9d3d97fc24e689ac0aa68aa6211e4
Autor:
Charles Langelier, Samantha Hao, David S. Weiss, Eileen M. Burd, David A. Hufnagel, Anders F. Johnson, Jacob E. Choby
Publikováno v:
mBio, vol 12, iss 1
mBio, Vol 12, Iss 1 (2021)
mBio
mBio, Vol 12, Iss 1 (2021)
mBio
The increasing frequency of antibiotic resistance poses myriad challenges to modern medicine. Environmental survival of multidrug-resistant bacteria in health care facilities, including hospitals, creates reservoirs for transmission of these difficul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b9f2195db064548223fa0cf2325862
https://escholarship.org/uc/item/1202d0cj
https://escholarship.org/uc/item/1202d0cj