Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jacob E, Lazarus"'
Autor:
Joseph S. Park, Jennifer D. Helble, Jacob E. Lazarus, Guanhua Yang, Carlos J. Blondel, John G. Doench, Michael N. Starnbach, Matthew K. Waldor
Publikováno v:
iScience, Vol 11, Iss , Pp 71-84 (2019)
Summary: The invasion of Chlamydia trachomatis, an obligate intracellular bacterium, into epithelial cells is driven by a complex interplay of host and bacterial factors. To comprehensively define the host genes required for pathogen invasion, we und
Externí odkaz:
https://doaj.org/article/aeb8a890a61a468d863b75026b321f07
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2637-2652 (2016)
Motor-cargo recruitment to microtubules is often the rate-limiting step of intracellular transport, and defects in this recruitment can cause neurodegenerative disease. Here, we use in vitro reconstitution assays with single-molecule resolution, live
Externí odkaz:
https://doaj.org/article/4c3ab9da012e4f009a757c57534e57ab
Autor:
Alline R. Pacheco, Jacob E. Lazarus, Brandon Sit, Stefanie Schmieder, Wayne I. Lencer, Carlos J. Blondel, John G. Doench, Brigid M. Davis, Matthew K. Waldor
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) has two critical virulence factors—a type III secretion system (T3SS) and Shiga toxins (Stxs)—that are required for the pathogen to colonize the intestine and cause diarrheal disease. Here, we ca
Externí odkaz:
https://doaj.org/article/340bfdb97ab94b00822ca588d8794534
Autor:
John S Albin, Jacob E Lazarus, Kristen M Hysell, David M Rubins, Lindsay Germaine, Caitlin M Dugdale, Howard M Heller, Elizabeth L Hohmann, Joshua J Baugh, Erica S Shenoy
Publikováno v:
Journal of the American Medical Informatics Association : JAMIA. 29(12)
Monkeypox virus was historically rare outside of West and Central Africa until the current 2022 global outbreak, which has required clinicians to be alert to identify individuals with possible monkeypox, institute isolation, and take appropriate next
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b188be8a861d8abe3ca4521db2e8ba9
https://pubmed.ncbi.nlm.nih.gov/36036367
https://pubmed.ncbi.nlm.nih.gov/36036367
Autor:
Wilfredo R Matias, Jacob M Koshy, Ellen H Nagami, Victor Kovac, Letumile R Moeng, Erica S Shenoy, David C Hooper, Lawrence C Madoff, Miriam B Barshak, Jennifer A Johnson, Christopher F Rowley, Boris Julg, Elizabeth L Hohmann, Jacob E Lazarus
Publikováno v:
Open forum infectious diseases. 9(8)
A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353b15c03e901a7bc6d5d4f36409cf16
https://pubmed.ncbi.nlm.nih.gov/35949403
https://pubmed.ncbi.nlm.nih.gov/35949403
Autor:
Emily P. Hyle, Stephen B. Calderwood, Edward T. Ryan, Camille N. Kotton, Jacob E. Lazarus, Sayon Dutta, Nesli Basgoz, Tyler S. Brown, Caitlin M Dugdale, Jacob E. Lemieux, Louise C. Ivers, Sandra B Nelson, Jennifer L. Reedy, Amy L. Miller, Rochelle P. Walensky, Kristen Hysell, Howard M. Heller, Erica S. Shenoy, John S. Albin, Miriam B Barshak, David M. Rubins, Rocío M. Hurtado, Andrea L. Ciaranello, David C. Hooper, Dustin McEvoy, Suzanne M. McCluskey, Hang Lee, Kimon C. Zachary
Publikováno v:
Clinical Infectious Diseases
Background Isolation of hospitalized persons under investigation (PUIs) for coronavirus disease 2019 (COVID-19) reduces nosocomial transmission risk. Efficient evaluation of PUIs is needed to preserve scarce healthcare resources. We describe the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c0a3d33b34370d9d7b0bd84adcc958
https://doi.org/10.1093/cid/ciab111
https://doi.org/10.1093/cid/ciab111
Autor:
Emily R, Ko, Ricardo, Henao, Katherine, Frankey, Elizabeth A, Petzold, Pamela D, Isner, Anja K, Jaehne, Nakia, Allen, Jayna, Gardner-Gray, Gina, Hurst, Jacqueline, Pflaum-Carlson, Namita, Jayaprakash, Emanuel P, Rivers, Henry, Wang, Irma, Ugalde, Siraj, Amanullah, Laura, Mercurio, Thomas H, Chun, Larissa, May, Robert W, Hickey, Jacob E, Lazarus, Shauna H, Gunaratne, Daniel J, Pallin, Guruprasad, Jambaulikar, David S, Huckins, Krow, Ampofo, Ravi, Jhaveri, Yunyun, Jiang, Lauren, Komarow, Scott R, Evans, Geoffrey S, Ginsburg, L Gayani, Tillekeratne, Micah T, McClain, Thomas W, Burke, Christopher W, Woods, Ephraim L, Tsalik, Ebbing, Lautenbach
Publikováno v:
JAMA network open. 5(4)
Bacterial and viral causes of acute respiratory illness (ARI) are difficult to clinically distinguish, resulting in the inappropriate use of antibacterial therapy. The use of a host gene expression-based test that is able to discriminate bacterial fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd20c71ad7af1dacb43d7c2e59b10f1
https://pubmed.ncbi.nlm.nih.gov/35420659
https://pubmed.ncbi.nlm.nih.gov/35420659
Autor:
Jacob E. Lazarus, Guanhua Yang, Carlos J. Blondel, Joseph Park, Jennifer D. Helble, John G. Doench, Michael N. Starnbach, Matthew K. Waldor
Publikováno v:
iScience, Vol 11, Iss, Pp 71-84 (2019)
iScience
iScience
Summary The invasion of Chlamydia trachomatis, an obligate intracellular bacterium, into epithelial cells is driven by a complex interplay of host and bacterial factors. To comprehensively define the host genes required for pathogen invasion, we unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4465c3570b56dde556c398c75b208395
http://www.sciencedirect.com/science/article/pii/S2589004218302402
http://www.sciencedirect.com/science/article/pii/S2589004218302402
Publikováno v:
PLoS Biology, Vol 11, Iss 7, p e1001611 (2013)
Regulation of microtubule dynamics in neurons is critical, as defects in the microtubule-based transport of axonal organelles lead to neurodegenerative disease. The microtubule motor cytoplasmic dynein and its partner complex dynactin drive retrograd
Externí odkaz:
https://doaj.org/article/a3c62b8d8f3341cebd008b1f4deedc3f
Autor:
Suzanne M. McCluskey, Kimon C. Zachary, Brent P. Little, Emily P. Hyle, Rochelle P. Walensky, Tasos Gogakos, Andrea L. Ciaranello, David C. Hooper, John A. Branda, Erica S. Shenoy, Sarah E Turbett, Caitlin M Dugdale, John J Chiosi, Jacob E. Lazarus, Melis N. Anahtar
Publikováno v:
Open Forum Infectious Diseases
Background Concerns about false-negative (FN) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid amplification tests (NAATs) have prompted recommendations for repeat testing if suspicion for coronavirus disease 2019 (COVID-19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f900c77fc68d9690d1cb8a53ca00d4
http://europepmc.org/articles/PMC7717411
http://europepmc.org/articles/PMC7717411