Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jacob De Vlieg"'
Autor:
Sander B. Nabuurs, Jan P.G. Klomp, Rob Leurs, Jacob De Vlieg, Iwan J.P. De Esch, Bas Vroling, Marijn P.A. Sanders, Luc Roumen, Chris De Graaf
Publikováno v:
Pharmaceuticals, Vol 4, Iss 9, Pp 1196-1215 (2011)
Recently the first community-wide assessments of the prediction of the structures of complexes between proteins and small molecule ligands have been reported in the so-called GPCR Dock 2008 and 2010 assessments. In the current review we discuss the d
Externí odkaz:
https://doaj.org/article/b817a1a6078842f9b85b0a7b3d4636bb
Autor:
Raoul Frijters, Marianne van Vugt, Ruben Smeets, René van Schaik, Jacob de Vlieg, Wynand Alkema
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 9, Pp 134-136 (2010)
The scientific literature represents a rich source for retrieval of knowledge on associations between biomedical concepts such as genes, diseases and cellular processes. A commonly used method to establish relationships between biomedical concepts fr
Externí odkaz:
https://doaj.org/article/e2699e9fc527418bbf2dec785f3f5188
Autor:
Marie-José C van Lierop, Wynand Alkema, Anke J Laskewitz, Rein Dijkema, Hans M van der Maaden, Martin J Smit, Ralf Plate, Paolo G M Conti, Christan G J M Jans, C Marco Timmers, Constant A A van Boeckel, Scott J Lusher, Ross McGuire, Rene C van Schaik, Jacob de Vlieg, Ruben L Smeets, Claudia L Hofstra, Annemieke M H Boots, Marcel van Duin, Benno A Ingelse, Willem G E J Schoonen, Aldo Grefhorst, Theo H van Dijk, Folkert Kuipers, Wim H A Dokter
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48385 (2012)
Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGR
Externí odkaz:
https://doaj.org/article/6e9843e211b74a5b893e7e79339992e9
Autor:
Marcel van Duin, Rita Azevedo, Hans Hamersma, Diep Vu-Pham, Arthur Oubrie, Scott J. Lusher, Rolien Bosch, Bert Kazemier, Hans C.A. Raaijmakers, Jacob de Vlieg, Koen J. Dechering, Ross McGuire
Publikováno v:
Journal of Biological Chemistry, 287, 20333-20343
Journal of Biological Chemistry, 287, 24, pp. 20333-20343
Journal of Biological Chemistry, 287, 24, pp. 20333-20343
Contains fulltext : 103894.pdf (Publisher’s version ) (Open Access) We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from two differing molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5603237fee702c88c44068b45f204787
https://doi.org/10.1074/jbc.m111.308403
https://doi.org/10.1074/jbc.m111.308403
Autor:
Rob van Gammeren, Deborah Cronin, Jacob de Vlieg, Eric J. Baede, Jan-Willem Boiten, Ernest den Bekker
Publikováno v:
Journal of Chemical Information and Modeling, 52, 6, pp. 1438-1449
Journal of Chemical Information and Modeling, 52, 1438-1449
Journal of Chemical Information and Modeling, 52, 1438-1449
Item does not contain fulltext Drug discovery teams continuously have to decide which compounds to progress and which experiments to perform next, but the data required to make informed decisions is often scattered, inaccessible, or inconsistent. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28bdf673a621a0f11bc63e551990f4a
https://doi.org/10.1021/ci200253g
https://doi.org/10.1021/ci200253g
Autor:
Ross McGuire, Rolien Bosch, Jacob de Vlieg, Niall M. Hamilton, Olaf Nimz, Koen J. Dechering, Angus R. Brown, Scott J. Lusher, Tsang Wai Lam, Arthur Oubrie, Diep Vu-Pham, Hans C.A. Raaijmakers
Publikováno v:
Journal of Biological Chemistry, 286, 35079-35086
Journal of Biological Chemistry, 286, 40, pp. 35079-35086
Journal of Biological Chemistry, 286, 40, pp. 35079-35086
The progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. We describe here two new pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe67a191b82ca4f7414febeccbc79a8
https://doi.org/10.1074/jbc.m111.273029
https://doi.org/10.1074/jbc.m111.273029
Autor:
Marijn P. A. Sanders, Sander B. Nabuurs, Luc Roumen, Jacob de Vlieg, Rob Leurs, Chris de Graaf, Iwan J. P. de Esch, Bas Vroling, Jan P. G. Klomp
Publikováno v:
Pharmaceuticals, Vol 4, Iss 9, Pp 1196-1215 (2011)
Pharmaceuticals
Pharmaceuticals, 4, 9, pp. 1196-1215
Pharmaceuticals, 4, 1196-1215
Pharmaceuticals
Pharmaceuticals, 4, 9, pp. 1196-1215
Pharmaceuticals, 4, 1196-1215
Recently the first community-wide assessments of the prediction of the structures of complexes between proteins and small molecule ligands have been reported in the so-called GPCR Dock 2008 and 2010 assessments. In the current review we discuss the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0979dc939a6701c6476a5a0087da2f6
https://hdl.handle.net/2066/91925
https://hdl.handle.net/2066/91925
Autor:
Scott J. Lusher, René C. van Schaik, Jacob de Vlieg, Jan-Willem Boiten, Ross McGuire, Rita Azevedo
Publikováno v:
Drug Discovery Today, 16(13-14), 555-568. Elsevier
Drug Discovery Today, 16, 13-14, pp. 555-568
Drug Discovery Today, 16, 555-568
Drug Discovery Today, 16, 13-14, pp. 555-568
Drug Discovery Today, 16, 555-568
The difference between biologically active molecules and drugs is that the latter balance an array of related and unrelated properties required for administration to patients. Inevitability, during optimization, some of these multiple factors will co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba8ab77004ea7843f06bceeeadf8bb3
https://doi.org/10.1016/j.drudis.2011.05.005
https://doi.org/10.1016/j.drudis.2011.05.005
Publikováno v:
Steroids. 75:314-322
Recent results showing that the binding characteristics of 33 steroids for human membrane progesterone receptor alpha (hu-mPRalpha) differ from those for the nuclear progesterone receptor (nPR) suggest that hu-mPRalpha-specific agonists can be identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9610a32bff2794217a3983631af4b0
https://doi.org/10.1016/j.steroids.2010.01.010
https://doi.org/10.1016/j.steroids.2010.01.010
Autor:
Ester Piek, Lutgarde M. C. Buydens, Jacob de Vlieg, Ron Wehrens, René C. van Schaik, Jorn R. de Haan, S. Bauerschmidt
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 11, Iss 1, p 158 (2010)
BMC Bioinformatics, 11, pp. 1-10
BMC Bioinformatics, 11, 1-10
BMC Bioinformatics, Vol 11, Iss 1, p 158 (2010)
BMC Bioinformatics, 11, pp. 1-10
BMC Bioinformatics, 11, 1-10
Background Gene expression data can be analyzed by summarizing groups of individual gene expression profiles based on GO annotation information. The mean expression profile per group can then be used to identify interesting GO categories in relation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6baab626fd6d5629bf4e74fda9ff3d
https://doi.org/10.1186/1471-2105-11-158
https://doi.org/10.1186/1471-2105-11-158