Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jacob D. Daniels"'
Autor:
Hengrui Liu, Sho Iketani, Arie Zask, Nisha Khanizeman, Eva Bednarova, Farhad Forouhar, Brandon Fowler, Seo Jung Hong, Hiroshi Mohri, Manoj S. Nair, Yaoxing Huang, Nicholas E. S. Tay, Sumin Lee, Charles Karan, Samuel J. Resnick, Colette Quinn, Wenjing Li, Henry Shion, Xin Xia, Jacob D. Daniels, Michelle Bartolo-Cruz, Marcelo Farina, Presha Rajbhandari, Christopher Jurtschenko, Matthew A. Lauber, Thomas McDonald, Michael E. Stokes, Brett L. Hurst, Tomislav Rovis, Alejandro Chavez, David D. Ho, Brent R. Stockwell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Small molecule drugs promise to remain a valuable tool in controlling the ongoing COVID-19 pandemic. Here the authors describe optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for potential treatment of COVID-19.
Externí odkaz:
https://doaj.org/article/ca1887901eef4f3082b30b23a613d463
Autor:
Vanessa A. N. Kraft, Carla T. Bezjian, Susanne Pfeiffer, Larissa Ringelstetter, Constanze Müller, Fereshteh Zandkarimi, Juliane Merl-Pham, Xuanwen Bao, Natasa Anastasov, Johanna Kössl, Stefanie Brandner, Jacob D. Daniels, Philippe Schmitt-Kopplin, Stefanie M. Hauck, Brent R. Stockwell, Kamyar Hadian, Joel A. Schick
Publikováno v:
ACS Central Science, Vol 6, Iss 1, Pp 41-53 (2019)
Externí odkaz:
https://doaj.org/article/6bf1885f0b7840f3938db0dc289ed06a
Autor:
Hengrui Liu, Sho Iketani, Arie Zask, Nisha Khanizeman, Eva Bednarova, Farhad Forouhar, Brandon Fowler, Seo Jung Hong, Hiroshi Mohri, Manoj S. Nair, Yaoxing Huang, Nicholas E. S. Tay, Sumin Lee, Charles Karan, Samuel J. Resnick, Colette Quinn, Wenjing Li, Henry Shion, Xin Xia, Jacob D. Daniels, Michelle Bartolo-Cruz, Marcelo Farina, Presha Rajbhandari, Christopher Jurtschenko, Matthew A. Lauber, Thomas McDonald, Michael E. Stokes, Brett L. Hurst, Tomislav Rovis, Alejandro Chavez, David D. Ho, Brent R. Stockwell
Publikováno v:
Nature communications. 13(1)
The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-19 therapy, given its likely druggability and essentiality in the viral maturation and replication cycle. Based on the conservation of 3CL protease substrate binding pocke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90cd5b380606682331ee6e11e86c64c
https://pubmed.ncbi.nlm.nih.gov/35393402
https://pubmed.ncbi.nlm.nih.gov/35393402
Autor:
Amy Y. Chan, Daniel W. Heindel, Christopher A. Vaiana, Jacob D. Daniels, Michael M. Gaschler, Yulia Y. Tyurina, Andrei V. Bekish, Pieter H. Bos, Lingplak Ye, Vadim V. Shmanai, Brent R. Stockwell, Lara K. Mahal, Eveliz Peguero-Pereira, Mikhail S. Shchepinov, Joleen M. Csuka, Eduard Reznik, Alexander A. Andia, Hengrui Liu, K. A. Woerpel, Valerian E. Kagan, Maksim A. Fomich, Annie J. Lin, Brisa Hurlocker, Dylan S. Zuckerman
Publikováno v:
Nature Chemical Biology. 14:507-515
Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the glutathione-dependent lipid-peroxide-scavenging network. FINO2 is an endoperoxide-containing 1,2-dioxolane that can initiate ferroptosis selectively in engineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e914e034d88a84e16836e37cf89228ed
https://doi.org/10.1038/s41589-018-0031-6
https://doi.org/10.1038/s41589-018-0031-6
Autor:
Helen Y. Figueroa, Caterina P. Profaci, Mathieu Herman, Bradley T. Hyman, Susanne Wegmann, Sheina Emrani, Peter Davies, Karen Duff, S. Abid Hussaini, Jacob D. Daniels, Hongjun Fu
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159463 (2016)
PLoS ONE
PLoS ONE
3D volume imaging using iDISCO+ was applied to observe the spatial and temporal progression of tau pathology in deep structures of the brain of a mouse model that recapitulates the earliest stages of Alzheimer’s disease (AD). Tau pathology was comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9468e66e88dd16a89c3349aefe898668
https://doi.org/10.1371/journal.pone.0159463
https://doi.org/10.1371/journal.pone.0159463
Autor:
Hongjun Fu, S Abid Hussaini, Susanne Wegmann, Caterina Profaci, Jacob D Daniels, Mathieu Herman, Sheina Emrani, Helen Y Figueroa, Bradley T Hyman, Peter Davies, Karen E Duff
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159463 (2016)
3D volume imaging using iDISCO+ was applied to observe the spatial and temporal progression of tau pathology in deep structures of the brain of a mouse model that recapitulates the earliest stages of Alzheimer's disease (AD). Tau pathology was compar
Externí odkaz:
https://doaj.org/article/dd6c376d0fad48e2bc7f2456a4cdbcac