Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jacob D Feala"'
Publikováno v:
Molecular Systems Biology, Vol 4, Iss 1, Pp 1-13 (2008)
Abstract The fruitfly Drosophila melanogaster is increasingly used as a model organism for studying acute hypoxia tolerance and for studying aging, but the interactions between these two factors are not well known. Here we show that hypoxia tolerance
Externí odkaz:
https://doaj.org/article/fb0315cf00d3457eb9bffa98c20565d2
Autor:
Jacob D Feala, Jorge Cortes, Phillip M Duxbury, Andrew D McCulloch, Carlo Piermarocchi, Giovanni Paternostro
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29374 (2012)
Cells are regulated by networks of controllers having many targets, and targets affected by many controllers, in a "many-to-many" control structure. Here we study several of these bipartite (two-layer) networks. We analyze both naturally occurring bi
Externí odkaz:
https://doaj.org/article/844f5bdef92a46d2937b17b93e143bcd
Autor:
Diego Calzolari, Stefania Bruschi, Laurence Coquin, Jennifer Schofield, Jacob D Feala, John C Reed, Andrew D McCulloch, Giovanni Paternostro
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 12, p e1000249 (2008)
Combination therapies are often needed for effective clinical outcomes in the management of complex diseases, but presently they are generally based on empirical clinical experience. Here we suggest a novel application of search algorithms -- origina
Externí odkaz:
https://doaj.org/article/2526c5f25f8041828c78ac87a4b444fa
Autor:
Kara Schmid, Jacob D. Feala, Bhaskar Dutta, Anders Wallqvist, Xueping Yu, Angela M. Boutté, Chenggang Yu, Jaques Reifman, Jitendra R. Dave, Gregory J. Tawa
Publikováno v:
Journal of Neuroscience Research
The multifactorial nature of traumatic brain injury (TBI), especially the complex secondary tissue injury involving intertwined networks of molecular pathways that mediate cellular behavior, has confounded attempts to elucidate the pathology underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81a03805bd54c19d04a71cd263cfc41
https://doi.org/10.1002/jnr.23503
https://doi.org/10.1002/jnr.23503
Autor:
Bhaskar Dutta, Kara Schmid, Frank C. Tortella, Xueping Yu, Chenggang Yu, Jaques Reifman, Mohamed Diwan M. AbdulHameed, Jitendra R. Dave, Jacob D. Feala
Publikováno v:
Journal of Neurotrauma. 30:1101-1116
The rate of traumatic brain injury (TBI) in service members with wartime injuries has risen rapidly in recent years, and complex, variable links have emerged between TBI and long-term neurological disorders. The multifactorial nature of TBI secondary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c1b070be775295039bcc368fa95709
https://doi.org/10.1089/neu.2012.2631
https://doi.org/10.1089/neu.2012.2631
Publikováno v:
Annals of the New York Academy of Sciences. 1123:169-177
Necrosis and apoptosis during acute myocardial infarction result in part from the inability of hypoxic cardiac myocytes to match ATP supply and demand. In contrast, hypoxia-tolerant organisms, such as Drosophila, can rapidly regulate cellular metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b72b32cc5ef15a8147d9cbbb5eca35
https://doi.org/10.1196/annals.1420.019
https://doi.org/10.1196/annals.1420.019
Autor:
Andrew D. McCulloch, Jacob D. Feala, Phillip M. Duxbury, Carlo Piermarocchi, Jorge E. Cortes, Giovanni Paternostro
Publikováno v:
Wiley interdisciplinary reviews. Systems biology and medicine. 2(2)
Effective therapy of complex diseases requires control of highly non-linear complex networks that remain incompletely characterized. In particular, drug intervention can be seen as control of signaling in cellular networks. Identification of control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b95ebe232ab4ef1946139e3489268ac
https://pubmed.ncbi.nlm.nih.gov/20836021
https://pubmed.ncbi.nlm.nih.gov/20836021
Publikováno v:
Molecular Systems Biology
The fruit fly D. melanogaster is increasingly used as a model organism for studying acute hypoxia tolerance and for studying aging, but the interactions between these two factors are not well known. Here we show that hypoxia tolerance degrades with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ea5232000d7aba5b20e4d2514c8189
http://arxiv.org/abs/0811.2015
http://arxiv.org/abs/0811.2015
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c9a72aeae4d34ea053c48f815444fb5
https://doi.org/10.1096/fasebj.22.1_supplement.756.3
https://doi.org/10.1096/fasebj.22.1_supplement.756.3
Publikováno v:
Progress in biophysics and molecular biology. 96(1-3)
Hypoxia is the major cause of necrotic cell death in myocardial infarction. Cellular energy supply and demand under hypoxic conditions is regulated by many interacting signaling and transcriptional networks, which complicates studies on individual pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6075e002534078ee7a597024ac6cb06
https://pubmed.ncbi.nlm.nih.gov/17870149
https://pubmed.ncbi.nlm.nih.gov/17870149